Dilatação dos espaços de Virchow-Robin em pacientes com migrânea

Júnior, Marcos Alberto da Costa Machado; Matos, Adriana Silva; Goyanna, Fabíola; Barbosa, Verônica Aline Oliveira; Vieira, Lauro Conceição

doi:10.1590/s0004-282x2001000200010

Cited by 9 publications

(10 citation statements)

References 13 publications

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“…For instance, the first study focused on a migraine population aged 13-56 years and observed a widening of the VRS in 28 (40.00%) patients with migraine compared with only 5 (7.10%) in the controls. 15 Moreover, the second study observed accentuated VRS in 61.00% of children with migraine aged 3-14 years, but only in 22.00% of children with TTH and 27.00% of children without headaches. 16 Despite differences in MRI field strength, the age range of the population, and the definition and interpretation of EPVS, the overall trend of the results is identical.…”

Section: The Association Between Epvs and Migrainementioning

confidence: 85%

“…Our study, which utilized a 3T MRI device to investigate the Chinese adult migraine population, is consistent with two earlier studies that used a 1.5T MRI device, indicating the involvement of EPVS in migraine. For instance, the first study focused on a migraine population aged 13–56 years and observed a widening of the VRS in 28 (40.00%) patients with migraine compared with only 5 (7.10%) in the controls 15 . Moreover, the second study observed accentuated VRS in 61.00% of children with migraine aged 3–14 years, but only in 22.00% of children with TTH and 27.00% of children without headaches 16 .…”

Section: Discussionmentioning

confidence: 98%

“…Several prior studies have focused on the relationship between EPVS and migraine. [15][16][17][18] For instance, one of these studies found that accentuated Virchow-Robin spaces (VRS) were significantly more common in children with migraine than in those with tension-type headache (TTH) or headachefree controls. 16 A case report of a 15-year-old boy indicated that hemiplegic migraine might be caused by giant tumefactive PVS.…”

Section: Introductionmentioning

confidence: 99%

“…Normal PVS are not visible on MRI; MRI‐visible enlarged perivascular spaces (EPVS) provide us with a non‐invasive method of indirectly reflecting the dysfunction of glymphatic drainage, 14 which could be widely used in clinical practice. Several prior studies have focused on the relationship between EPVS and migraine 15–18 . For instance, one of these studies found that accentuated Virchow‐Robin spaces (VRS) were significantly more common in children with migraine than in those with tension‐type headache (TTH) or headache‐free controls 16 .…”

Section: Introductionmentioning

confidence: 99%

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Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI

Yuan,

Li,

Tang

et al. 2023

Ann Clin Transl Neurol

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Objective To explore whether MRI‐visible enlarged perivascular spaces (EPVS) are associated with migraine and may serve as a predictor of migraine. Then further explore its correlation with migraine chronification. Methods A total of 231 participants (healthy control [HC] = 57, episodic migraine [EM] = 59, chronic migraine [CM] = 115) were included in this case–control study. A 3T MRI device and the validated visual rating scale were used to assess the grades of EPVS in centrum semiovale (CSO), midbrain (MB), and basal ganglia (BG). Comparisons between the two groups were made using the chi‐square or Fisher's exact tests to initially determine whether high‐grade EPVS were associated with migraine and migraine chronification. A multivariate logistic regression model was constructed to further investigate the role of high‐grade EPVS in migraine. Results The prevalence of high‐grade EPVS in CSO and MB were significantly higher in patients with migraine than in HCs (CSO: 64.94% vs. 42.11%, P = 0.002; MB: 55.75% vs. 29.82%, P = 0.001). Subgroup analysis showed no statistical difference between patients with EM and CM (CSO: 69.94% vs. 62.61%, P = 0.368; MB: 50.85% vs. 58.26%, P = 0.351). Individuals with high‐grade EPVS in CSO (odds ratio [OR]: 2.324; 95% confidence interval [CI]: 1.136–4.754; P = 0.021) and MB (OR: 3.261; 95% CI: 1.534–6.935; P = 0.002) were more likely to suffer from migraine. Interpretation This case–control study showed that high‐grade EPVS in CSO and MB in clinical practice with the underlying mechanism of dysfunction of the glymphatic system could be a predictor of migraine, but no significant correlation had been found with migraine chronification.

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Section: The Association Between Epvs and Migrainementioning

confidence: 85%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI

Yuan,

Li,

Tang

et al. 2023

Ann Clin Transl Neurol

View full text Add to dashboard Cite

show abstract

“…A study by Machado Jr. et al (2001) found that between equal numbers of age-matched patients suffering from migraine of unspecified subtypeand and headache-free controls ranging from adolescence to middle age, 40% of migraine patients showed enlarged PVS compared to only 7.1% of controls. 49 After comparing migraine of unspecified subtype in pediatric patients to adult patients with post-pubertal migraine onset, Schick et al (1999) showed that 61% of pediatric migraineurs had larger clusters of PVS compared to only 27% of pediatric controls and 13% adult migraineurs. 6 In contrast to these findings and other prior studies, a more recent investigation by Husøy et al (2016) discovered a decrease in PVS quantity for MWoA patients in the basal ganglia (BG) and hemispheric white matter (HWM); additionally, they showed only small differences in PVS number between headache groups and headache-free patients, as well as finding no significant association between PVS and headache category, frequency, or disease duration.…”

Section: Perivascular Spaces (Pvs)mentioning

confidence: 99%

Structural MRI in Migraine: A Review of Migraine Vascular and Structural Changes in Brain Parenchyma

Barisano²,

Phung

et al. 2023

J Cent Nerv Syst Dis

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Migraine is a complex and common disorder that affects patients around the world. Despite recent advances in this field, the exact pathophysiology of migraine is still not completely understood. Structural MRI sequences have revealed a variety of changes to brain parenchyma associated with migraine, including white matter lesions, volume changes, and iron deposition. This Review highlights different structural imaging findings in various types of migraine and their relationship to migraine characteristics and subtypes in order to improve our understanding of migraine, its pathophysiologic mechanisms, and how to better diagnose and treat it.

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Correlation between migraine and cerebral small vessel disease: A case–control study

Zhang,

Li,

2023

European Journal of Pain

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BackgroundMicrocirculatory pathology is one of the pathophysiological theories of migraine, which may present as visually subclinical lesions. Image markers of cerebral small vessel disease (CSVD) have been investigated in elderly migraineurs. However, past studies looked at only part of image features, and the conclusions may have been hindered by confounding factors. The relationship between migraine and CSVD signs needs reliable demonstrations.MethodsWe conducted a case–control study by recruiting episodic young migraineurs from a tertiary headache centre, with tension‐type headache (TTH) and healthy controls. Distinct image features of microvascular damage and baseline characteristics across groups were assessed, and multivariate linear regression was performed to evaluate the risk factors for image abnormalities in migraineurs.ResultsForty‐eight migraineurs, 32 TTHs and 49 healthy controls were included. The median age was 32 year‐old. 58.7% of the participants were female. The Scheltens score and volume of white matter hyperintensities (WMHs) in migraineurs, and the number of Virchow–Robin spaces (VRSs) in both migraineurs and TTHs were different from those in normal controls. No lacunar infarct‐like lesions (ILLs) or cerebral microbleeds (CMBs) were found. Age, education level (high level: β = −2.23, lobar WMHs), attack duration (long duration: β = 3.81, lobar WMHs) and attack frequency were independent risk factors for Scheltens score and volume of WMH in migraineurs. Migraine aura (β = −2.389), attack frequency and education level were correlated with the number of VRSs.ConclusionsMigraine was associated with WMHs and VRSs. Aura, attack duration, attack frequency, age and education level were risk factors for image abnormalities of CVSD in migraineurs.SignificanceThis study provides a novel and comprehensive landscape of CSVD MRI features in young migraineurs, and it fills the blank of CMBs and VRSs which received less attention, with more persuasive, more reliable and stronger evidence of the association between CSVD and migraine. Our results also imply some new feature of TTH and the possible pathophysiology of the migraine course as well as new clues for the early management of migraine in terms of visual brain damage.

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Dilatação dos espaços de Virchow-Robin em pacientes com migrânea

Cited by 9 publications

References 13 publications

Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI

Enlarged perivascular spaces in patients with migraine: a case–control study based on 3T MRI

Structural MRI in Migraine: A Review of Migraine Vascular and Structural Changes in Brain Parenchyma

Correlation between migraine and cerebral small vessel disease: A case–control study

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