Dilantin Sodium Poisoning

Mandelbaum, Harry

doi:10.1001/archneurpsyc.1941.02280170047003

Cited by 26 publications

(3 citation statements)

References 8 publications

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“…Lymphadenopathy was noted in nearly all cases and 20 had hepatomegaly but the only sign of definite importance according to these authors was splenomegaly which to them suggested reticulosis and was found in 3 cases (chronic myeloid leukaemia, chronic lymphatic leukaemia and reticulum cell sarcoma). Here they were at variance with the findings of Taylor and Potashnik (1951) and Mandelbaum and Kane (1941) who described splenomegaly in exfoliative erythrodermia due to drugs. Laboratory investigations, which included full blood count, E.S.R., bone marrow, urine, serum protein estimation and biopsy of skin and lymph nodes were similarly unrewarding, histopathology being frequently misleading.…”

supporting

confidence: 68%

Carcinoma of the Rectum Presenting with Exfoliative Erythrodermia

Pe¹

1965

Br J Cancer

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supporting

confidence: 68%

Carcinoma of the Rectum Presenting with Exfoliative Erythrodermia

Pe¹

1965

Br J Cancer

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“…Phenytoin hypersensitivity reaction was first reported in 1941 by Mandelbaum and Kane ( 15). This syndrome is usually manifested by the onset of fever, rash, lymphadenopathy, and hepatitis.…”

Section: Discussionmentioning

confidence: 99%

Hypersensitivity Reaction in a Child Due to Lamotrigine

et al. 1999

Pediatric Dermatology

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Lamotrigine is an anticonvulsant with a broad spectrum of activity that has been approved in the United States for use in adults with either partial or generalized seizures. This drug is being widely prescribed by pediatricians and neurologists because it is effective in children with idiopathic, resistant, generalized seizures and does not impair cognition. As with other anticonvulsants, a hypersensitivity syndrome has been described. Anticonvulsant hypersensitivity syndrome consists of the hallmark features of fever, rash, and lymphadenopathy. We report the first case of hypersensitivity syndrome in a child due to lamotrigine in which we believe the coadministration of valproic acid increased the duration of the reaction. Our patient had a high spiking fever, generalized morbilliform eruption, facial edema, lymphadenopathy, eosinophilia, atypical lymphocytosis, and an elevation in his liver function tests. The syndrome resolved with the discontinuation of the medication. Anticonvulsant hypersensitivity syndrome may occur with the administration of lamotrigine. Variable presentations may be seen, as hypersensitivity syndromes may be multisystem in nature. The prompt recognition of the signs and symptoms of this condition allows an accurate diagnosis so that the drug may be discontinued and other anticonvulsant treatment options instituted.

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“…In the course of the long history of their therapeutic use a broad spectrum of side effects has been attributed to these drugs (Sparberg, 1963), most frequently consisting of visual disturbances, gingival hyperplasia (King, 1952;Sparberg, 1963;Goodman and Gilman, 1970), and various exanthemas (Mandelbaum and Kane, 1941;Loscalzo, 1948;Martin et al, 1954;Watts, 1962). Other side effects described have been haematological abnormalities (Benhamon and Albon, 1953;Best and Paul, 1950;Sparberg, 1963), benign (Siegal and Berkovitz, 1961;Harrington et al, 1962;Holland and Mauer, 1965;Goodman and Gilman, 1970) and, rarely, malignant lymphadenopathies (Hyman and Sommers, 1966), hepatitis (Chaiken et al, 1950;Gropper, 1956;Bajoghli, 1961;Pezzimenti and Andrew, 1970), disease states resembling serum sickness (Bravermann and Levin, 1963), lupus erythematosus (Miescher and Delacretaz, 1953;Lindquist, 1957;Rallison et al, 1961) and periarteritis nodosa (Van Wyk and Hoffman, 1948), and endocrine disorders such as hirsutism (Sparberg, 1963;Kniper, 1969).…”

Section: Introductionmentioning

confidence: 99%