The large N reduction is an equivalence between large N gauge theories and matrix models discovered by Eguchi and Kawai in the early 80s. In particular the continuum version of the quenched Eguchi-Kawai model may be useful in studying supersymmetric and/or chiral gauge theories nonperturbatively. We apply this idea to matrix quantum mechanics, which is relevant, for instance, to nonperturbative studies of the BFSS Matrix Theory, a conjectured nonperturbative definition of M-theory. In the bosonic case we present Monte Carlo results confirming the equivalence directly, and discuss a possible explanation based on the Schwinger-Dyson equations. In the supersymmetric case we argue that the equivalence holds as well although some care should be taken if the rotational symmetry is spontaneously broken. This equivalence provides an explicit relation between the BFSS model and the IKKT model, which may be used to translate results in one model to the other.