Dihydrotestosterone induces arterial stiffening in female mice
Alec C. Horton,
Mary M. Wilkinson,
Isabella Kilanowski-Doroh
et al.
Abstract:Background
Androgens are important sex hormones in both men and women and are supplemented when endogenous levels are low, for gender transitioning, or to increase libido. Androgens also circulate at higher levels in women with polycystic ovarian syndrome, a condition that increases the risk for cardiovascular diseases including hypertension and arterial stiffness. Since our previous work shows an important role for the G protein-coupled estrogen receptor (GPER) in arterial stiffness, we hypoth… Show more
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