Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia

Fu, Danlan; Huang, Junfei; Li, Kaitao; Chen, Yuxin; He, Ye; Sun, Yang; Guo, Yilong; Du, Lijuan; Qu, Qian; Miao, Yong; Hu, Zhiqi

doi:10.1016/j.biopha.2021.111247

Cited by 60 publications

(28 citation statements)

References 56 publications

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“…Interestingly, apart from the mentioned involvements in various physiological conditions, dysregulation of Wnt/β-catenin signaling is strongly associated with the development of AGA—a dermatological disorder whereby the hair is abnormally shed from the skin where it normally should be presented. Particularly, it is suppressed in AGA [ 13 , 22 , 24 , 25 , 26 , 27 ]. Indeed, various Wnt proteins play a substantial role in the hair growth cycle [ 2 ].…”

Section: The Importance Of Wnt/β-catenin Signaling In Hair Growthmentioning

confidence: 99%

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Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Papukashvili

Rcheulishvili

Liu

et al. 2021

Cells

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Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and safety. Ultimately, there is a strong need for developing a feasible remedy for preventing and treating AGA. The Wnt/β-catenin signaling pathway is critical in hair restoration. Thus, AGA treatment via modulating this pathway is rational, although challenging. Dickkopf-related protein 1 (DKK1) is distinctly identified as an inhibitor of canonical Wnt/β-catenin signaling. Thus, in order to stimulate the Wnt/β-catenin signaling pathway, inhibition of DKK1 is greatly demanding. Studying DKK1-targeting microRNAs (miRNAs) involved in the Wnt/β-catenin signaling pathway may lay the groundwork for the promotion of hair growth. Bearing in mind that DKK1 inhibition in the balding scalp of AGA certainly makes sense, this review sheds light on the perspectives of miRNA-mediated hair growth for treating AGA via regulating DKK1 and, eventually, modulating Wnt/β-catenin signaling. Consequently, certain miRNAs regulating the Wnt/β-catenin signaling pathway via DKK1 inhibition might represent attractive candidates for further studies focusing on promoting hair growth and AGA therapy.

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Section: The Importance Of Wnt/β-catenin Signaling In Hair Growthmentioning

confidence: 99%

“…This result also supports the idea that miR-218 may be one of the best candidates for AGA therapy. Therefore, it would be prudent to study the impact of miR-218 on DKK1 levels in the mouse model of human AGA induced by DHT treatment [ 27 ].…”

Section: Mirna Involvement In Hair Growth Regulationmentioning

confidence: 99%

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Papukashvili

Rcheulishvili

Liu

et al. 2021

Cells

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“…AGA causes the progressive miniaturization of hair follicles and induces androgenlike effects in the epithelial cells of hair follicles in androgen-dependent regions [4,29]. The androgens secreted by the human body combine with type 2 5α-reductase in hair follicles to form DHT, which attacks hair follicles, causing them to shrink, which weakens hair strength, and eventually causes hair loss [30,31].…”

Section: Discussionmentioning

confidence: 99%

Alleviation of Androgenetic Alopecia with Aqueous Paeonia lactiflora and Poria cocos Extract Intake through Suppressing the Steroid Hormone and Inflammatory Pathway

Zhang

Cao

et al. 2021

Pharmaceuticals

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Paeonia lactiflora Pallas (PL) and Poria cocos Wolf (PC) have been traditionally used to treat inflammatory diseases reported in Dongui Bogam and Shen Nong Ben Cao Jing, traditional medical books in Korean and China, respectively. We determined the efficacies and the molecular mechanisms of PL, PC, and PL + PC aqueous extracts on androgenetic alopecia (AGA) induced by testosterone propionate in C57BL/6 mice. The molecular mechanisms of PL and PC in AGA treatment were examined using experimental assays and network pharmacology. The AGA model was generated by topically applying 0.5% testosterone propionate in 70% ethanol solution to the backs of mice daily for 28 days while the normal-control (Normal-Con; no AGA induction) mice applied 70% ethanol. The 0.1% PL (AGA-PL), 0.1% PC (AGA-PC), 0.05% PL + 0.05% PC (AGA-MIX), and 0.1% cellulose (AGA-Con; control) were supplemented in a high-fat diet for 28 days in AGA-induced mice. Positive-control (AGA-Positive) were administered 2% finasteride daily on the backs of the AGA mice. Hair growth rates decreased in the order of AGA-PL, AGA-MIX, AGA-PC, AGA-Positive, and AGA-Con after 21 days of treatment (ED21). On ED28, skins were completely covered with hair in the AGA-PL and AGA-MIX groups. Serum testosterone concentrations were lower in the AGA-PL group than in the AGA-Con group and similar to concentrations in the Normal-Con group, whereas serum 17β-estradiol concentrations showed the opposite pattern with increasing aromatase mRNA expression (p < 0.05). In the dorsal skin, DKK1 and NR3C2 mRNA expressions were significantly lower, but TGF-β2, β-Catenin, and PPARG expressions were higher in the AGA-PL and AGA-PC groups than in the AGA-Con group (p < 0.05), whereas TNF-α and IL-6 mRNA expressions were lower in the AGA-PL, AGA-MIX, and Normal-Con groups than in the AGA-Con group (p < 0.05). The phosphorylation of Akt and GSK-3β in the dorsal skin was lower in AGA-Con than normal-Con, and PL and MIX ingestion suppressed their decrease similar to the Normal-Con. In conclusion, PL or PL + PC intake had beneficial effects on hair growth similar to Normal-Con. The promotion was related to lower serum testosterone concentrations and pro-inflammatory cytokine levels, and inhibition of the steroid hormone pathway, consistent with network pharmacology analysis findings.

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“…The secretion of DHT is regulated by an enzyme called 5 alpha reductase. [9][10] The scalp hair grows at a rate of a half an inch per month. In most area of scalp, the 15% of hair are in growing phase and 85% are in the resting phase.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Different Pattern of Hair Loss in Pakistani Men Using BASP Classification

Nasreen¹,

Malik²,

Memon³

et al. 2021

PJMHS

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Objective: To determine the frequency of different hair loss using BASP classification in Pakistani men. Study Design: Cross-Sectional Study. Setting: Study was conducted at Department of Dermatology, Abbasi Shaheed Hospital, Karachi. Duration: Six months starting 6th August 2019 till 5th January 2020 Material and Methods: Total 157 diagnosed patients with hair loss who met the diagnostic criteria were included. Brief history was taken and demographic information was recorded after taking written informed consent. Male pattern of hair loss (MPHL) was checked and categorized using BASP classification. Data was analyzed by SPSS 24.0. Results: In this study out of 157 patients, mean and standard deviation of age and duration of hair loss were 33.14±12.49 years and 1.89± 0.44 years, respectively. The Pattern of hair loss distribution showed that 34 (21.7%) were L type, 66 (42%) were M type, 35 (22.3%) were C type, and 22 (14%) were U type patterned hair loss. Conclusion: Assessment of male pattern hair loss using BASP classification found that M type hair loss was more prevalent. Currently, there are effective medical and surgical treatments available for men. However, the knowledge of pattern of hair loss in our population would help in choosing suitable treatment plans. Keywords: Male Pattern hair loss, Androgenic alopecia and BASP classification

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Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia

Cited by 60 publications

References 56 publications

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

Alleviation of Androgenetic Alopecia with Aqueous Paeonia lactiflora and Poria cocos Extract Intake through Suppressing the Steroid Hormone and Inflammatory Pathway

Frequency of Different Pattern of Hair Loss in Pakistani Men Using BASP Classification

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