Dihydropyrimidinones as potent anticancer agents: Insight into the structure–activity relationship

Abstract

Cancer is a serious disease that has been around for a long time but currently has no sustainable solution. Several medications currently available offer an opportunity for the manifestation of cancer treatment; however, the "search for better" has led to the development and study of a variety of new scaffolds. Dihydropyrimidinones (DHPMs) are a privileged scaffold, prominent for their versatile range of biological activities. In recent years, the anticancer potential of these unsaturated pyrimidine ring systems has been traversed, along with their synthesis methods and the interlinked mechanisms leading to the anticancer activity. This review summarizes the structure-activity relationship of DHPMs as potential anticancer agents. This study is a short review of their synthesis, mechanism of action, and structure-activity relationships (SARs) that are answerable for the anticancer activity of DHPMs and have been thoroughly researched and assessed.

Synthesis, antiproliferative activity, 3D‐QSAR, and molecular docking studies of novel L‐carvone‐derived pyrimidine‐urea compounds

“…Cancer is a grievous disease that has been threatening the health of humans, and there is no feasible approach for perpetual cure at present. One of the effective strategies for controlling and managing this disease is the application of antiproliferative drugs [1]. Heterocyclic compounds are widely used in medicine and pesticide science because most of them have broad‐spectrum biological activities.…”

Ultrahigh-Performance Fiber-Supported Iron-Based Ionic Liquid for Synthesizing 3,4-Dihydropyrimidin-2-(1H)-ones in a Cleaner Manner

“…As important multicomponent reactions, the Biginelli reactions involve a one-pot condensation of three common reagents to afford 3,4-dihydropyrimidin-2-(1 H )-ones (DHPMs). − Currently, the application of the Biginelli reaction to prepare DHPMs has attracted renewed attention because the derivatives of DHPMs can identify promising biological activities. , And more recently, DHPMs has been used in diversiform life science research for structure modifications, and prominent pharmaceutical activities have been affirmed, especially in anticancer and antioxidant agents, − the meliorate detection of antiretroviral drug, and Helicobacter pylori urease inhibitors . Therefore, the development of new catalysts with high efficiency for the synthesis of DHPMs has gained increasing interest, and many novel catalytic materials, including nanoparticles and nanocomposites − and metallic oxides (i.e., oxidovanadium and oxidoniobium) , on different types of supports, have been attempted in the three-component Biginelli reactions.…”