Dihydroisocoumarins produced by Botryosphaeria parva an endophytic fungus from Eugenia jambolana

Araújo, Ângela R.; Monfardini, JD; Chapla, VM; Lopes, MN; Silva, Dhs; Cavalheiro, AJ; Bolzani, Vanderlan da Silva

doi:10.1055/s-0032-1320774

Cited by 3 publications

(5 citation statements)

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“…It is interesting to consider, however, that many of the SMs reported from endophytic Botryosphaeria are phytotoxic. For example, Botryosphaeria mamane and Botryosphaeria parva , endophytes from Garcinia mangostana and Eugenia jambolana , respectively, produce mellein and other phytotoxic derivatives, raising the question as to what roles these compounds play during interaction (Araujo et al ., ; Pongcharoen et al ., ).…”

Section: Pathogenic Dothideomycetes and Their Smsmentioning

confidence: 99%

The past, present and future of secondary metabolite research in the Dothideomycetes

Muria-Gonzalez

Chooi

Breen

et al. 2014

Molecular Plant Pathology

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The Dothideomycetes represents a large and diverse array of fungi in which prominent plant pathogens are over-represented. Species within the Cochliobolus, Alternaria, Pyrenophora and Mycosphaerella (amongst others) all cause diseases that threaten food security in many parts of the world. Significant progress has been made over the past decade in understanding how some of these pathogens cause disease at a molecular level. It is reasonable to suggest that much of this progress can be attributed to the increased availability of genome sequences. However, together with revealing mechanisms of pathogenicity, these genome sequences have also highlighted the capacity of the Dothideomycetes to produce an extensive array of secondary metabolites, far greater than originally thought. Indeed, it is now clear that we appear to have only scratched the surface to date in terms of the identification of secondary metabolites produced by these fungi. In the first half of this review, we examine the current status of secondary metabolite research in the Dothideomycetes and highlight the diversity of the molecules discovered thus far, in terms of both structure and biological activity. In the second part of this review, we survey the emerging techniques and technologies that will be required to shed light on the vast array of secondary metabolite potential that is encoded within these genomes. Experimental design, analytical chemistry and synthetic biology are all discussed in the context of how they will contribute to this field.

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Section: Pathogenic Dothideomycetes and Their Smsmentioning

confidence: 99%

The past, present and future of secondary metabolite research in the Dothideomycetes

Muria-Gonzalez

Chooi

Breen

et al. 2014

Molecular Plant Pathology

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“…This finding represents a new frontier in the study of myrtucommulones because the availability of strains to be cultured in vitro may provide access to increased amounts of these products for further investigations. To date, myrtucommulones A, B and D (32)(33)(34) were identified in cultures of endophytic strains of N. australe of myrtle (Myrtus communis) [27,28]. Antiproliferative activity effects on the human prostatic cancer cell lines DU145 and PC3 were observed for a mixture of 32 and 34 [27].…”

Section: Myrtucommulonesmentioning

confidence: 99%

“…Tyrosol is one of the most frequently detected metabolites in cultures of botryosphaeraceous fungi [58]. In fact, it was identified in culture extracts of several phytopathogenic strains of N. australe [16,17,30], N. parvum [30,32] and N. luteum [18,30] (Table 2).…”

Section: Phenols and Alcoholsmentioning

confidence: 99%

Secondary Metabolites Produced by Neofusicoccum Species Associated with Plants: A Review

2021

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The genus Neofusicoccum is comprised of approximately 50 species with a worldwide distribution and is typically associated with plants. Neofusicoccum is well-known for the diseases it causes on economically and ecologically relevant host plants. In particular, members of this genus are responsible for grapevine diseases, such as leaf spots, fruit rots, shoot dieback, bud necrosis, vascular discoloration of the wood, and perennial cankers. Many secondary metabolites, including (−)-botryoisocoumarin A, botryosphaerones, cyclobotryoxide and isosclerone, were identified from species of Neofusicoccum and their structural variability and bioactivities might be associated with the role of these compounds in the fungal pathogenicity and virulence. In this review, we summarize the secondary metabolites from Neofusicoccum species focusing on the role of these compounds in the interaction between the fungus and host plant.

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“…2021), and it is also found in cocoa powder, which makes Mellein as a potential biomarker in food industry (Araujo et al . 2012).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, Mellein was synthesized by various fungal endophytes, for example, L. theobromae, Nigrospora sp., Aspergillus sp., L. pseudotheobromae which possess diverse bioactive properties such as antimicrobial, antitrypanosomal, cytotoxic, bioherbicidal, insecticidal and larvicidal activities (Kendagor et al 2013;Hussain et al 2015;Kamal et al 2017;Adetunji et al 2018). Moreover, Mellein acts as a biocontrol agent against Fusarium moniliforme, Alternaria alternata and Botrytis cinerea fungal plant pathovars (Morales-Sanchez et al 2021), and it is also found in cocoa powder, which makes Mellein as a potential biomarker in food industry (Araujo et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Isolation, purification and structural elucidation of Mellein from endophytic fungus Lasiodiplodia theobromae strain (SJF-1) and its broad-spectrum antimicrobial and pharmacological properties

Saraswathi

Meshram

Siva

et al. 2022

Letters in Applied Microbiology

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Significance and Impact of the Study: In the present study, the bioactive metabolite Mellein was represented as a broad-spectrum antimicrobial agent produced by Lasiodiplodia theobromae strain (SJF-1) isolated from the medicinal plant Syzygium cumini. In addition, Mellein exhibited drug-like characteristics through in silico absorption, distribution, metabolism, and excretion pharmacological studies. Hence, from the above studies, Mellein could be considered as a potential drug candidate and also a biocontrol agent in the medical, agricultural and pharmaceutical sectors.

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Dihydroisocoumarins produced by Botryosphaeria parva an endophytic fungus from Eugenia jambolana

Cited by 3 publications

References 0 publications

The past, present and future of secondary metabolite research in the Dothideomycetes

The past, present and future of secondary metabolite research in the Dothideomycetes

Secondary Metabolites Produced by Neofusicoccum Species Associated with Plants: A Review

Isolation, purification and structural elucidation of Mellein from endophytic fungus Lasiodiplodia theobromae strain (SJF-1) and its broad-spectrum antimicrobial and pharmacological properties

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