“…There is some evidence that peroxidase (POD) isoenzymes may directly be involved in the capsaicinoid metabolism, since the vanillyl moiety of capsaicin is readily oxidized by these enzymes (Zapata, Calderon, Munoz, & Ros Barcelo, 1992). Bernal, Calderón, Pedreno, Munoz, Barceló, & de Cáceres (1993a, 1993b suggested that PODs contribute to capsaicinoid degradation, in particular of capsaicin and dihydrocapsaicin. This hypothesis is corroborated by the fact that PODs are mainly located in the placenta and the outermost epidermal cell layers, where the capsaicinoids are also found (Bernal, de Cáceres, & Barceló, 1994).…”