Dihydrocaffeic acid, a major microbial metabolite of chlorogenic acids, shows similar protective effect than a yerba mate phenolic extract against oxidative stress in HepG2 cells

Antiproliferative and cytotoxic effects of green coffee and yerba mate extracts, their main hydroxycinnamic acids, methylxanthine and metabolites in different human cell lines

“…Data on ROS production when cancer cells were incubated with YME and when normal cells were incubated with both YME or its CQA derivatives confirmed our previous results with 5-CQA, 3,5-DCQA (Baeza et al, 2014), DHCA and DHFA (Baeza et al, 2016a) or other herbal extracts which contain these phenolic compounds such as green coffee (Baeza et al, 2014) and Corema album extracts (León-González et al, 2012). The antioxidant activity might therefore contribute to reduce the oxidative stress associated with cancer initiation and progression.…”

Absorption and metabolism of yerba mate phenolic compounds in humans

“…It is important to highlight that microbial metabolites of hydroxycinnamates, mainly dihydrocaffeic acid, has proved to be as effective as the non-metabolized chlorogenic acids protecting human cells from oxidative stress (Baeza et al, 2016). Also, both dihydrocaffeic acid and dihydroferulic acid, the major metabolite in plasma (Table 3), were more effective than their phenolic precursors inhibiting platelet activation (Baeza, Bachmair, Wood, Mateos, Bravo, & de Roos, 2017).…”

“…In fact, yerba mate has been employed for the treatment of different pathologies in indigenous tribal medicine. In recent years, several of these pharmacological activities have been documented in scientific papers, demonstrating antioxidant, anti-inflammatory, anti-obesity, or cardioprotective effects, although its intake has also been correlated with certain types of cancer, specially of the oral cavity (Arçari et al, 2009;de Mejía, Song, Heck, & Ramírez-Mares, 2010;Pimentel et al, 2013, Bravo et al, 2014Baeza, Sarriá, Mateos, & Bravo, 2016). Thus, intake of yerba mate has been related to oesophageal cancer, associated to the high temperature mate is traditionally consumed (Lubin et al, 2014).…”

Main Human Urinary Metabolites after Genipap (Genipa americana L.) Juice Intake

“…We identified 4 phenolic derivatives: dihydroxyhydrocinnamic acid, hydroxyhydrocinnamic acid, scopoletin and 3,4-dihydroxyphenylacetate. Dihydroxyhydrocinnamic acid, hydroxyhydrocinnamic acid and 3,4-dihydroxyphenylacetate are produced by bacterial degradation in the intestine and colon and possess antioxidant and antiproliferative activities [ 42 , 43 , 52 , 53 ]. Scopoletin is a coumarin that is widespread in the plant kingdom and has diverse pharmacological properties as an anti-inflammatory, and antitumor and radical-scavenging activities [ 43 ].…”