Dihydroazines Based on α,β-Unsaturated Ketones Reactions

Cyclocondensation Reations of 3‐Amino‐1,2,4‐triazole with 3‐(Benzylidene)‐6‐fluoro‐thiochroman‐4‐ones to Tetracyclically Fused Dihydropyrimidines and Pyrimidines

“…Also N,N-dimethylformamide and 1-methylpyrrolidin-2-one were more favorable to the reaction than AcOH; and the azaheterocycles could be synthesized directly by the condensation reaction without the effect of dehydrogenizing reagent, which has not been reported in the literature. [1][2][3][4][5][6] …”

“…Cyclocondensations of aminoazoles with α,β-unsaturated ketones are the most widespread approach to prepare fused dihydroazaheterocycles, [1][2][3][4][5][6] which could be transformed into azaheterocycles by dehydrogenization in the system of NBS and methanol 3 or tetrahydroazaheterocycles by reducement with NaBH 4 . 5 However, the cases that azaheterocycles were prepared using cyclocondensation reactions were rarely reported.…”

Facile synthetic approaches for new series of pyrazole-4-carbonitrile derivatives

“…On the other hand, nitrogen-containing 1,2-and 1,3-binucleophiles are important reagents in heterocyclic chemistry, and their reactions with electrophiles are considered as facile synthetic approaches for obtaining diverse heterocyclic systems containing azole and condensed azole moieties [8][9][10][11]. In view of these observations and in continuation of our current interest in synthesis of polysubstituted heterocycles [12][13][14][15][16], we describe herein a facile synthesis of a novel class of pyrazole-4-carbonitrile-based heterocycles starting from 3-acetyl-1-(4-fluorophenyl)-5-phenyl-1H-pyrazole-4-carbonitrile (3).…”

Synthesis and Antimicrobial Screening of some New Pyrimido[1,2-a]Benzimidazole Derivatives

“…Binucleophiles of aminoazole type are quite important reagents in modern heterocyclic chemistry, and their reactions with electrophiles are the most widespread and facile synthetic approach for obtaining diverse heterocyclic systems containing azole moiety. The most investigated area of aminoazole chemistry is their two-component reactions with ketoesters, β-dicarbonyls or α,β-unsaturated aldehydes and ketones yielding fused azoloazines [10][11] . Our research group is associated with synthesis and evaluation of biological activities of pyrimidine, pyridine and related nitrogen containing heterocyclic ring system from last decade [12][13][14][15][16] .…”