Dihydroartemisinin loaded layered double hydroxide nanocomposites for tumor specific photothermal–chemodynamic therapy

Lu, Jingsong; Guo, Zhenhu; Lei, Sheng; Gao, Fei; Gu, Zi; Xu, Jing; Chi, Yongjie; Xu, Weixin; Zhang, Junxin; Takuya, Nonaka; Yu, Jing; Zhao, Lingyun

doi:10.1039/d0tb01964j

Cited by 27 publications

(36 citation statements)

References 35 publications

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“…In other words, two types of transition metal elements are used to achieve efficient CDT via Fenton and/or Fenton‐like reaction at the same time. The currently reported dual metal ions‐mediated strategies are based on manganese/iron, [ 352–358 ] copper/iron, [ 359–365 ] copper/manganese, [ 366,367 ] etc.…”

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

“…In another example, Lu and co‐workers developed MnMgFe‐LDH (LDH was the abbreviation of layered double hydroxide) loaded with DHA (termed LDH/DHA) for enhanced PTT/CDT. [ 355 ] First, LDH containing Mg 2+ and Fe 3+ was synthesized through a simple co‐precipitation approach. Then the authors conducted the partial isomorphic substitution between Mn 2+ and Mg 2+ to obtain MnMgFe‐LDH.…”

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

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Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

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Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in the tumor region, was first proposed by Bu, Shi, and co‐workers in 2016. Recently, with the rapid development of Fenton and Fenton‐like nanomaterials, CDT has attracted tremendous attention because of its unique advantages: 1) It is tumor‐selective with low side effects; 2) the CDT process does not depend on external field stimulation; 3) it can modulate the hypoxic and immunosuppressive tumor microenvironment; 4) the treatment cost of CDT is low. In addition to the Fe‐involved CDT strategies, the Fenton‐like reaction‐mediated CDT strategies have also been proposed, which are based on many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, and zinc. Moreover, CDT has been combined with other therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, and immunotherapy for achieving enhanced anticancer effects. Besides, there have also been studies that extend the application of CDT to the antibacterial field. This review introduces the latest advancements in the nanomaterials‐involved CDT from 2018 to the present and proposes the current limitations as well as future research directions in the related field.

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Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

Small

337

212

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“…In contrast, undersized LDHs are easily to fill in the pores between collagen fibers, and in this case, it would be unrealistic to expect the formation of surface-conductive layer. LDHs can be produced via different methods, including co-precipitation, [28][29][30] hydrothermal, [31,32] calcination-reconstruction, [33,34] ion exchange, [35] and template methods. [36] Hydrothermal method was selected to prepare LDHs in this work because the produced LDHs had high crystallinity and narrow particle size distribution.…”

Section: Fabrication Of Pedot:pss/ldhs/leather Composite Sensormentioning

confidence: 99%

Flame‐Retardant PEDOT:PSS/LDHs/Leather Flexible Strain Sensor for Human Motion Detection

Zong

Tan

2022

Macromol. Rapid Commun.

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Flexible piezoresistive sensors have demonstrated great potential in human–motion–detection applications. However, it still remains a challenge to fabricate strain sensors with high sensitivity, broad sensing range, and good linear response to strain. In this report, a simple and scalable fabrication strategy is developed to construct high performance strain sensors by using leather as the substrates to filtrate poly(3,4‐ethylenedioxythiophene): poly(4‐styrenesulfonate) (PEDOT:PSS) modified layered double hydroxides (LDHs) suspensions. The naturally aligned collagen fibers in leather enable size selection for the 2D conductive materials and as such dual‐conductive pathways are effectively formed on the surface and in the matrix of leather. Due to the unique design of conductive networks, the prepared sensor possesses high gauge factor (maximum value of 2326.84), tunable strain range (0–70%), fast tensile response time (160 ms), and good stability in 1000 stretching‐relaxing/compression‐relaxing cycles, making it suitable for various human motion detections including coughing and large‐scale motions of joint bending. In addition, the incorporated LDHs is a non‐toxic flame retardant, which is helpful to reduce electronic fire risk and can bring added value to the sensor.

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“…In addition, PDA aids in PTT through synergistic enhancement of CT and CDT effects by increasing cell death via heat generation from the specific light source. Lu et al reported dihydroartemisinin-loaded manganese ion-doped magnesium-Iron-LDH NCs for synergistic CDT/PTT [15]. The developed NC's showed tremendous photothermal properties with a photothermal conversion efficacy of up to 10.7% [15].…”

Section: Introductionmentioning

confidence: 99%

“…Lu et al reported dihydroartemisinin-loaded manganese ion-doped magnesium-Iron-LDH NCs for synergistic CDT/PTT [15]. The developed NC's showed tremendous photothermal properties with a photothermal conversion efficacy of up to 10.7% [15]. In another study, Sun et al reported indocyanine green intercalated copper (Cu) substituted LDH for combinational PTT/PDT therapy to inhibit tumor growth in vivo.…”

Section: Introductionmentioning

confidence: 99%

Hierarchical Two-Dimensional Layered Double Hydroxide Coated Polydopamine Nanocarriers for Combined Chemodynamic and Photothermal Tumor Therapy

et al. 2021

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The combination of chemodynamic therapy (CDT) and photothermal therapy (PTT) has proven to be successful in combating the challenges associated with cancer therapy. A combination of these therapies can maximize the benefits of each therapeutic modality through endogenous reduction-oxidation (redox) reaction and external laser power induction. In the current work, we have designed a copper-aluminum layered double hydroxide (CuAl-LDH) loaded doxorubicin (DOX) by a co-precipitation method; the surface was coated with polydopamine (PDA). The synthesized CuAl-LDH@DOX@PDA nanocarrier (NC) served as a Fenton-like catalyst with photothermal properties. It is well known that metal ion incorporated NCs can induce intracellular depletion of reduced glutathione (GSH) levels along with the reduction of Cu2+ to Cu+. The Cu+ ions in turn react with DOX leading to the generation of intracellular hydrogen peroxide (H2O2) molecules to produce the highly toxic hydroxyl radicals (•OH) through a Fenton-like reaction. The enhanced absorption of CuAl@DOX@PDA at 810 nm, greatly improved the photothermal efficiency in comparison with bare CuAl-LDH and CuAl-LDH@DOX. In vitro studies revealed the tremendous CDT/PTT efficacy of CuAl@DOX@PDA in suppressing A549 cancer cells. Furthermore, reactive oxygen species (ROS) assays and intracellular levels of various ROS cascade biomolecules support our findings in the efficient destruction of cancer cells through synergistic CDT/PTT therapy.

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Dihydroartemisinin loaded layered double hydroxide nanocomposites for tumor specific photothermal–chemodynamic therapy

Abstract: With the inspiration to develop new cancer nanotherapeutics by repurposing old drugs, in the current study, a novel two dimensional nanomedicine namely Mn doped, dihydroartemisinin (DHA) loaded layered double hydroxide...

Cited by 27 publications

References 35 publications

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Flame‐Retardant PEDOT:PSS/LDHs/Leather Flexible Strain Sensor for Human Motion Detection

Hierarchical Two-Dimensional Layered Double Hydroxide Coated Polydopamine Nanocarriers for Combined Chemodynamic and Photothermal Tumor Therapy

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