Digoxin-like immunoreactive substances in urine and serum from preterm and term infants: Relationship to renal excretion of sodium

Ebara, Hirotaka; Suzuki, Shigeyoshi; Nagashima, Kanji; Shimano, Shunichi; Kuroume, Takayoshi

doi:10.1016/s0022-3476(86)81061-7

Cited by 32 publications

(17 citation statements)

References 10 publications

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“…More recently, we [4][5][6] and others [7][8][9][10][11] have reported finding an endogenous digoxin-like immunoreactive substance(s) (DLIS) in the perinatal period. This substance(s) is of fetal origin and serum levels correlate neg atively with gestational age [5,11], Some workers [9,12] have suggested that DLIS might be among the pathologic factors in volved in hyponatremia encountered in pre term infants [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

A Study into the Nature and Organ Source of Digoxin-Like Immunoreactive Substance(s) in the Perinatal Period

et al. 1989

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Digoxin-like immunoreactive substance(s) (DLIS) was isolated from sera and autopsy-derived tissue obtained from premature and full-term neonates. The highest tissue level of DLIS was in the small bowel followed by the adrenal, gallbladder and liver. Of the fluids examined, meconium had the highest level of DLIS. Preparative high performance liquid chromatography fractionation of cord blood generated at least six different fractions which not only contained DLIS material but also inhibited canine kidney Na⁺/K⁺-ATPase activity. Recovery/inhibition studies indicated that 72% of the canine kidney Na⁺/K⁺-ATPase inhibition within one fraction could be accounted for on the basis of progesterone content of the fraction.

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Section: Introductionmentioning

confidence: 99%

A Study into the Nature and Organ Source of Digoxin-Like Immunoreactive Substance(s) in the Perinatal Period

et al. 1989

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“…In previous studies on [DLIS] in premature infants the time of [DLIS] measurements had not been determined prospectively, but was adapted to the need for other clinical tests [11][12][13][14]. The absolute values of [DLIS] found in those studies cannot be compared with values of [DLIS] found in our study, because different assays were applied.…”

Section: Dlis -Impact Of Gestational Age and Effect Of Prenatal Steroidsmentioning

confidence: 97%

“…The results of other studies are conflicting regarding this issue. Negative [11,14] and positive [16] correlations between gestational age and [DLIS] at birth and during the first 13 days after birth were found in infants with gestational ages ranging from 25 to 40 weeks, whereas [DLIS] was unrelated to gestational age in specimens obtained by cordocentesis during pregnancy [22].…”

Section: Dlis -Impact Of Gestational Age and Effect Of Prenatal Steroidsmentioning

confidence: 99%

“…Ebara et al [14] reported a positive correlation between (DLIS) and the fractional excretion of sodium in newborns (25-40 weeks), investigated during the whole neonatal period from birth to 28 days after birth. However, this positive correlation (r 2 = 0.12) was weak and can hardly be interpreted as pointing to a relevant inhibition of renal Na + / K + -ATPase activity by DLIS.…”

Section: Dlis and Distal Tubular Functionmentioning

confidence: 99%

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Digoxin-Like Immunoreactive Substance in Nonoliguric Hyperkalemia of the Premature Infant

et al. 2003

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Nonoliguric hyperkalemia of premature infants probably results from a transient inhibition of membrane-bound Na⁺/K⁺-ATPase during the first 24 h after birth. We hypothesized that the endogenous digitalis-like activity of the serum of premature infants, which inhibits the Na⁺/K⁺-ATPase, triggered hyperkalemia. Serum concentrations of potassium ([K⁺]) and of the digoxin-like immunoreactive substance ([DLIS]) were measured during the first 24 h after birth in 60 infants including 30 infants <30 gestational weeks. Contrary to our hypothesis, there was a negative linear correlation between [DLIS] at birth and [K⁺] 24 h after birth (r² = 0.24, p < 0.002). 24 h after birth there was no correlation between [DLIS] and [K⁺]. Thus, a major role of DLIS in nonoliguric hyperkalemia could not be established.

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“…Studies in the perinatal period have re vealed tissue distribution of EOLS with the highest content in the fetal/neonatal adrenals followed by the gut and the brain [13,14] and there have been reports indicating that plas ma levels and urinary excretion of EOLS inversely correlate with gestational and post natal ages [15][16][17][18], Moreover, significant pos itive correlation has been found between neo natal EOLS and fractional sodium excretion implying that EOLS might be involved in sodium and volume regulation during the ear ly postnatal life [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Urinary Excretion of Endogenous Ouabain-Like Substance in Furosemide-Treated Neonates: Its Relation to Renal Excretory Pattern and Endocrine Factors

Sulyok¹,

Adamovits

Worgall

et al. 1997

Neonatology

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The present study was undertaken to define the possible role of endogenous ouabain-like substance (EOLS) in controlling renal excretory pattern, in mediating the renal responses to furosemide and in inducing endocrine reactions in furosemide-treated neonates. Ten newborn infants with mean birthweight of 2,752 g and mean gestational age of 37.1 weeks were given furosemide in a dose of 1 mg/kg. Prior to and following furosemide therapy, urine was collected for a period of 12 h and analyzed for creatinine, osmolality, sodium and potassium, as well as for EOLS, arginine vasopressin (AVP), aldosterone and endothelin-1 (ET-1). In response to furosemide administration, urine flow rate and urinary osmolar, sodium and potassium excretion increased significantly, whereas creatinine excretion remained unchanged. Furthermore, following furosemide therapy, urinary excretion of EOLS (148.7 ± 70.8 vs. 200.1 ± 98.1 pg/kg/h) and AVP (19.5 ± 5.4 vs. 27.8 ± 7.8 pg/kg/h) tended to increase, whereas ET-1 (36.0 ± 5.6 vs. 61.4 ± 8.7fmol/kg/h, p < 0.01) and aldosterone (507 ± 120 vs. 751 ± 203 ng/kg/h, p < 0.05) increased significantly. Prior to furosemide, urinary EOLS excretion was found to correlate positively with diuresis (r = 0.80, p < 0.01), sodium (r = 0.91, p < 0.001), creatinine (r = 0.75, p < 0.001), osmolar (r = 0.96, p < 0.001), ET-1 (r = 0.90, p < 0.001) and AVP (r = 0.92, p < 0.001) excretion. After furosemide, urinary EOLS excretion significantly correlated only with diuresis (r = 0.69, p < 0.05), ET-1 (r = 0.77, p < 0.01) and AVP (r = 0.92, p < 0.001). Urinary EOLS proved to be independent of aldosterone excretion irrespective of furosemide administration. It is concluded that urinary EOLS excretion is closely related to neonatal renal excretory pattern and it may have a role in controlling diuresis and natriuresis. The renal response to furosemide appears to be independent of EOLS, although interdependent endocrine reactions can be induced by furosemide which may modulate the production rate and urinary excretion of EOLS.

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Digoxin-like immunoreactive substances in urine and serum from preterm and term infants: Relationship to renal excretion of sodium

Cited by 32 publications

References 10 publications

A Study into the Nature and Organ Source of Digoxin-Like Immunoreactive Substance(s) in the Perinatal Period

A Study into the Nature and Organ Source of Digoxin-Like Immunoreactive Substance(s) in the Perinatal Period

Digoxin-Like Immunoreactive Substance in Nonoliguric Hyperkalemia of the Premature Infant

Urinary Excretion of Endogenous Ouabain-Like Substance in Furosemide-Treated Neonates: Its Relation to Renal Excretory Pattern and Endocrine Factors

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