Digitising chemical synthesis in automated and robotic flow

Abstract

Continuous flow chemical synthesis is already known to have many attributes that gives it superiority over batch in several respects. To expand these advantages with those from automation only drives...

Evolving scenario of big data and Artificial Intelligence (AI) in drug discovery

“…Chemputer is a recently developed platform that gives a detailed recipe for molecule synthesis and is exercised in compound synthesis automation. Three pharmaceutical compounds, diphenhydramine hydrochloride, rufinamide, and sildenafil, have been successfully automated through this method [ 169 , 170 ]. The purity and yield of the synthesized compounds were comparable with or better than the manual synthesis.…”

Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

“…2 Incorporation of innovative techniques that allows real-time data acquisition, in-process monitoring by process analytical technology (PAT), inline downstream processing (such as workup and purification), automation and use of artificial intelligence (AI) with continuous flow technology has been a very interesting approach to streamlining multistep synthesis and realise a smart and efficient continuous flow manufacturing of APIs. 7–18…”

“…To address this, the pharmaceutical industry has to start embracing the ethos of the 4th industrial revolution, whereby enabling technologies such as continuous flow manufacturing, data science, process analytical technologies and automation are integrated to ensure quality, affordability, availability, safety and sustainability. 1,7,8,18 The 4th industrial revolution will radically change how technology is used by the pharmaceutical industry to ensure efficiency, productivity and sustainability. Furthermore, the industry needs to use the quality by design (QbD) principles that allows it to design, develop and control processes based on a thorough understanding to ensure better rapid and robust development and performance of chemical processes.…”

Fidelity of Robotic Chemical Operations of Homogenous and Heterogeneous Reactions

“…[7][8][9] Another great impact of automation in chemistry was well presented in the search of new materials, which required multiple dimensions of parameters to be optimized in a huge amount of optimization works. [10][11][12] In the established ways to fulfill the automation, flow chemistry was widely adopted from laboratory scale [13][14][15] to industrial productions. 16 Recently, one seminal work of Burger and co-workers exhibited the breakthrough of robotic chemistry in their research on the photocatalyst for hydrogen production from water.…”