Digitalis Intoxication Misdiagnosed as Depression—Revisited

Song, You Hwi; Terao, Takeshi; Shiraishi, Yumiko; Nakamura, Jun

doi:10.1176/appi.psy.42.4.369

Cited by 10 publications

(2 citation statements)

References 3 publications

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“…Their adverse effects on the central nervous system have been reported that includes depression and psychosis but not PD [48], [49]. This may be due to the fact that DA neuron degeneration takes time to manifest and will likely result in symptoms at a much later time point after the offensive drug exposure.…”

Section: Discussionmentioning

confidence: 99%

Zebrafish Chemical Screening Reveals the Impairment of Dopaminergic Neuronal Survival by Cardiac Glycosides

et al. 2012

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Parkinson's disease is a neurodegenerative disorder characterized by the prominent degeneration of dopaminergic (DA) neurons among other cell types. Here we report a first chemical screen of over 5,000 compounds in zebrafish, aimed at identifying small molecule modulators of DA neuron development or survival. We find that Neriifolin, a member of the cardiac glycoside family of compounds, impairs survival but not differentiation of both zebrafish and mammalian DA neurons. Cardiac glycosides are inhibitors of Na+/K+ ATPase activity and widely used for treating heart disorders. Our data suggest that Neriifolin impairs DA neuronal survival by targeting the neuronal enriched Na+/K+ ATPase α3 subunit (ATP1A3). Modulation of ionic homeostasis, knockdown of p53, or treatment with antioxidants protects DA neurons from Neriifolin-induced death. These results reveal a previously unknown effect of cardiac glycosides on DA neuronal survival and suggest that it is mediated through ATP1A3 inhibition, oxidative stress, and p53. They also elucidate potential approaches for counteracting the neurotoxicity of this valuable class of medications.

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Section: Discussionmentioning

confidence: 99%

Zebrafish Chemical Screening Reveals the Impairment of Dopaminergic Neuronal Survival by Cardiac Glycosides

et al. 2012

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“…Of other cardiovascular medications, hydralazine and digoxin are linked with psychiatric side effects. Confusion and visual hallucination are common side effects of digoxin and occur at therapeutic doses, while delirium and delusion are seen at toxic doses [61]. Interestingly, there are few reports of the link between the use of some angiotensin receptor blockers e.g.…”

Section: Cardiovascular Agentsmentioning

confidence: 99%

Prescription medication-induced psychosis: A high alert for drug experts

Taslim¹,

Edge²

2020

JCP

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Psychosis is a complex mental illness of behavioral, psychological, and emotional disturbances. Secondary psychosis can be elicited by prescription medications and literature is replete with examples of such drugs. Objectives: The goal of this article is to gather information from multiple published sources to highlight the culprit prescription medications that are linked with psychotic episodes and compose the findings into a simplified, standalone publication for readers to conveniently become aware of this phenomenon. It is also intended to reiterate the critical role and significance of the pharmacist as a vital player in a health care team. Methods: The scientific literature was searched on the PubMed database using the key search phrase “psychosis, medicines or drug or prescription.” The search was limited to the time period from 1960-2019 to ensure the inclusion of the vast majority of previously reported cases of currently available medicines and their related psychoses. Conclusion: Commonly prescribed medications can cause serious, albeit preventable, psychiatric issues. Pharmacists as vital players in patient care can avert the untoward psychotic episode by taking timely steps in notifying the prescribers or counseling the patient on measures to avoid serious and fatal psychotic issues.

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