Digitalis and strophanthus---cardiac glycosides

Davies, M K; Hollman, Arthur

doi:10.1136/hrt.80.1.4

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…The most important CG-containing plant families are Apocynaceae, incl. Asclepiadaceae (Adenium [1], Cerbera [2], Cryptostegia [3], Nerium [4,5], Parepigynum [6,7], Periploca [8][9][10], Strophanthus [11][12][13][14][15], Thevetia [16][17][18][19][20][21][22]), Brassicaceae (Erysimum [23][24][25][26][27][28][29], and Lepidium [30]), Celastraceae (Euonymus [31,32], and Lophopetalum [33]), Convallariaceae (Convallaria [34][35][36][37][38][39][40][41][42][43][44][45]), Crassulaceae (Cotyledon [46], and Tylecodon [47,48]), Hyacinthaceae (Schizobasis [49], and Urginea …”

Section: Introductionmentioning

confidence: 99%

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Babula¹,

Masařík²,

Adam³

et al. 2013

ACAMC

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The cardiac glycosides are a group of compounds isolated from plants and some animals. They have been used in therapy for heart failure for many years. The cytotoxic effect of many cardiac glycosides has been demonstrated, but the mechanism of action is very complicated and complex, and Na+/K+-ATPase surely plays a crucial role in it. On the other hand, Na+/K+-ATPase is regulated by many endogenous factors, such as hormones or FXYD proteins, whose role in regulating the cell cycle has been studied intensively. This review focuses on the role of Na+/K+-ATPase in regulating the cell growth, the cell cycle and the cell proliferation and on the involvement of cardiac glycosides in regulating Na+/K+-ATPase. The cytotoxic effect of cardiac glycosides is discussed with respect to the apoptotic mechanisms possibly induced by these compounds. Novel strategies in cancer therapy based on cardiac glycosides are discussed as are possibilities for counteracting multidrug resistance by using cardiac glycosides. The aim of this review is to present cardiac glycosides not only as pharmaceuticals used in the management of heart failure, but also as potent cytotoxic agents with potential uses in cancer treatment.

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Section: Introductionmentioning

confidence: 99%

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Babula¹,

Masařík²,

Adam³

et al. 2013

ACAMC

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show abstract

“…The clinical manifestations and management are similar to those for digitalis overdose. 112,113 Tupistra chinensis Tupistra chinensis is a flowering plant found in South Asia, from South China to Sumatra. It is traditionally used for the treatment of inflammatory diseases in southwestern China.…”

Section: Rauwolfia Serpentinamentioning

confidence: 99%

Native Medicines and Cardiovascular Toxicity

Bhalla

Thirumalaikolundusubramanian²,

Fung

et al. 2015

Heart and Toxins

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“…Sir ,—The beautifully illustrated “Stamps in cardiology” on digitalis1 was fascinating. Ever since my medical school days, I have been wondering about the reason behind the plant’s common name—the foxglove.…”

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confidence: 99%

Stamps in cardiology: foxglove

Cheng

1999

Heart

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Digitalis and strophanthus---cardiac glycosides

Cited by 4 publications

References 9 publications

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

Native Medicines and Cardiovascular Toxicity

Stamps in cardiology: foxglove

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