Digital volumetric measurement of mammographic density and the risk of overlooking cancer in Japanese women

Sawada, Terumasa; Akashi, Shunsuke; Nakamura, Seigo; Kuwayama, Takashi; Enokido, Katsutoshi; Miwa, Yosuke; Hashimoto, Rikako; Ide, Toshimi; Masuda, Hiroko; Taruno, Kanae; Oyama, Hiroto; Takamaru, Tomoko; Kanada, Yoko; Ikeda, Minako; Kosugi, Natsuko; Sato, Hiroki; Nakayama, Sadayoshi; Ata, Arisa; Tonouchi, Yumi; Sakai, Haruna; Matsunaga, Yuki; Matsutani, Akiko

doi:10.1007/s12282-017-0763-2

Cited by 18 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study showed AW were more likely to have low MBD (65%), whereas high MBD was seen in the majority of JWJ (90%). The high MBD result among JWJ was consistent with findings by Sawada (2017) (Sawada, 2017). Odds ratios provided further evidence of differing MBD between ethnicities.…”

Section: Discussionsupporting

confidence: 89%

“…Women living in Australia who were born in countries with predominantly Asian ancestry had high MBD (Bell et al, 2019). In Japan, high MBD was observed in 78% of non-symptomatic women and 87% of breast cancer patients using a quantitative MBD measurement (Sawada, 2017). A study comparing the MBD of Japanese women in Hawaii and Japan reported that the former had significantly higher percent densities than the latter (Maskarinec et al, 2002).…”

Section: Research Articlementioning

confidence: 99%

See 1 more Smart Citation

Mammographic Breast Density of Japanese Women Living in Australia: Implications for Breast Screening Policy

Mizukoshi

Hossain

Poulos

2019

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Breastscreen Australia targets women aged 50-74 for screening mammography and the Japanese Breast Cancer Society targets women aged 40-74 (Japanese Breast Cancer Society, 2015; Australian Government, 2016). Previous BCI studies in multi-ethnic countries have reported that BCI rates vary between ethnicities, and BCI rates among migrants did not exhibit the same characteristics of either their country of origin or their host country (Maskarinec and Noh, 2004; Albeshan et al., 2018b). Women of Asian descent living in North America have a markedly increased BCI rate (Health Quality Ontario, 2007), and the BCI rates for Japanese American women have also demonstrated a rapid increase.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Research Articlementioning

confidence: 99%

Mammographic Breast Density of Japanese Women Living in Australia: Implications for Breast Screening Policy

Mizukoshi

Hossain

Poulos

2019

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

show abstract

“…Indeed, the rate of dense breasts in our study was relatively higher than the rate found in previous Western studies about imaging features of high-risk women [3, 20]. Sawada et al [26] also reported that the false-negative rate for Japanese women with dense breasts was high. For our current study, in all the cases where mammography was unable to detect the lesions, the breast density was described as either heterogeneous or extreme density.…”

Section: Discussioncontrasting

confidence: 71%

“…The strong tendency of high-risk groups to have dense breast tissue is known [25]. The rate of Japanese women with dense breasts is especially higher than Western people [26–28]. In addition, it has been suggested that breast density is associated with the risk of breast cancer [29, 30].…”

Section: Discussionmentioning

confidence: 99%

The clinical impact of MRI screening for BRCA mutation carriers: the first report in Japan

Murakami

Tozaki²,

Nakamura

et al. 2019

Breast Cancer

Self Cite

View full text Add to dashboard Cite

Background There is no consensus on the appropriate surveillance for high-risk women with breast cancer in Japan. We investigated their imaging features and pathological characteristics to build a proper surveillance system for asymptomatic high-risk individuals in the future. Methods We retrospectively reviewed 93 female (median age 43 years) BRCA1 and BRCA2 mutation carriers from our institutional clinical database from 2011 to 2017. The study population was composed of 112 breast cancers. Mammography and MRI were reviewed by examiners blinded to patients’ clinical history. Final surgical or biopsy histopathology served as the reference standard in all the patients. Results Fifty-nine breast cancers met selection criteria; of these, 30 were BRCA1-associated tumors, and 29 were BRCA2-associated tumors. Invasive ductal carcinoma was the most prevalent type in both BRCA1 and BRCA2. There were statistically significant differences in phenotype, nuclear grade, and Ki-67 labeling index between BRCA1 and BRCA2 mutation carriers. Additionally, imaging findings on mammography and MRI were statistically different. Tumors in BRCA2 carriers demonstrated mammographic calcifications more frequently, while those in BRCA1 carriers demonstrated a mass or architectural distortion ( P < 0.001). Enhancement pattern on MRI also significantly differed between the two subgroups ( P = 0.006). The size of MRI-detected lesions was statistically smaller than the size of those detected by other modalities ( P = 0.004). Conclusions The imaging and histological characteristics of BRCA1/2 mutation carriers were consistent with other countries’ studies. MRI-detected lesions were significantly smaller than lesions detected by non-MRI modality. All lesions in BRCA1 mutation carriers could be detected by MRI.

show abstract

“…Breast cancer is one of the most common female tumors, and is a leading cause of female mortality worldwide. The incidence of breast cancer is on the increase annually with a trend towards the younger population (1,2). With the continuous development of medical technology, research on the pathogenesis of breast cancer has revealed abundant information that was previously unknown.…”

Section: Introductionmentioning

confidence: 99%

Effect of HMGN2 on proliferation and apoptosis of MCF-7 breast cancer cells

et al. 2018

View full text Add to dashboard Cite

We investigated the effect of high mobility group protein N2 (HMGN2) on the proliferation and apoptosis of the human MCF-7 breast cancer cell line, and its effect on tumor growth in a subcutaneous heterotopic transplantation tumor model of breast cancer. The cell viability assay was used to verify the effect of the recombinant human HMGN2 on MCF-7 cell proliferation. The Transwell chamber assay was used to verify the effect of HMGN2 on MCF-7 cell migration. Flow cytometry and Hoechst staining were used to detect the effect of HMGN2 on MCF-7 cell apoptosis. MCF-7 was injected to establish a subcutaneous heterotopic transplantation tumor model of breast cancer in nude mice. The size, weight and volume of tumor in each group were compared after the administration of different concentrations of HMGN2 solution around the tumor tissue at day 1, 3, 5 and 7. The tumor tissue was removed and cut into sections, and the apoptotic cells in tumors of nude mice were detected by a TUNEL kit. The CCK-8 assay showed that HMGN2 at different concentrations inhibited the proliferation of the MCF-7 breast cancer cells, and the proliferation of MCF-7 cells were significantly inhibited when the concentration of HMGN2 reached 3 µg/ml (P<0.01). The Transwell chamber assay showed that 3 µg/ml of HMGN2 significantly decreased the migration capacity of MCF-7 cells (P<0.01). Flow cytometry and Hoechst staining showed that 3 µg/ml of HMGN2 significantly increased apoptosis of MCF-7 cells (P<0.01). After the nude mouse model of breast cancer was established, HMGN2 at different concentrations was injected around the tumor tissue at day 1, 3, 5 and 7. We demonstrated that the growth of breast cancer was significantly inhibited when the concentration of HMGN2 reached 15 µg/ml. TUNEL staining showed that the number of apoptotic cells in the 15 µg/ml dose group was significantly higher than that in the control group (P<0.01). Therefore, in vitro and in vivo experiments proved that recombinant human HMGN2 could significantly inhibit the proliferation and migration of breast cancer cells, which increased the apoptosis of breast cancer cells and exerted anti-breast cancer effects, which enriched our understanding of the biological roles of HMGN2.

show abstract

Digital volumetric measurement of mammographic density and the risk of overlooking cancer in Japanese women

Cited by 18 publications

References 21 publications

Mammographic Breast Density of Japanese Women Living in Australia: Implications for Breast Screening Policy

Mammographic Breast Density of Japanese Women Living in Australia: Implications for Breast Screening Policy

The clinical impact of MRI screening for BRCA mutation carriers: the first report in Japan

Effect of HMGN2 on proliferation and apoptosis of MCF-7 breast cancer cells

Contact Info

Product

Resources

About