Digital ulcers in scleroderma: staging, characteristics and sub-setting through observation of 1614 digital lesions

Abstract

In SSc, digital lesions are represented by DPS, DU, calcinosis and gangrene, and provide an evidence-based DU subsetting according to their origin and main characteristics. Subsetting may be helpful for a precise DU evaluation and staging, and in randomized controlled trials for a precise identification of those DUs that are to be included in therapeutic studies.

Prolonged Tp-e interval and Tp-e/QT correlates well with modified Rodnan skin severity score in patients with systemic sclerosis

“…Basic demographic characteristics including age, gender, BMI, systolic and diastolic blood pressure (BP) and HR of the whole population were recorded. Patients with SSc were screened in terms of disease duration (defined as interval between date of diagnosis and inclusion into study), and presence of digital ulcer [16], Raynaud's phenomenon [17] and severity of skin involvement in SSc patients were determined by the modified Rodnan method and modified Rodnan skin severity score (MR-SSS) calculated for all SSc patients. At more detailed method description for MR-SSS can be found in a study reported by Czirjak et al [18].…”

Increased Intrarenal Arterial Stiffness May Predict the Occurrence of New Digital Ulcers in Systemic Sclerosis

“…The DUs were classified according to Amanzi et al as follows: DUs derived from digital pitting scar (DPS), pure DUs, DUs derived from calcinosis, and DUs derived from gangrene (12 …”

Raynaud’s phenomenon — the clinical picture, treatment and diagnostics

“…Patients very often suffer from small erosions, ulcers and even necrosis of the fingers in rare cases [3,9,10]. Hypoxia is also a main cause of bone resorption and autoamputation of distal phalanges in patients diagnosed with SSc ( Fig.…”