Digital twins and Bayesian dynamic borrowing: Two recent approaches for incorporating historical control data
Carl‐Fredrik Burman,
Erik Hermansson,
David Bock
et al.
Abstract:Recent years have seen an increasing interest in incorporating external control data for designing and evaluating randomized clinical trials (RCT). This may decrease costs and shorten inclusion times by reducing sample sizes. For small populations, with limited recruitment, this can be especially important. Bayesian dynamic borrowing (BDB) has been a popular choice as it claims to protect against potential prior data conflict. Digital twins (DT) has recently been proposed as another method to utilize historica… Show more
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