Digital Twins and Automation of Care in the Intensive Care Unit

Chase, J. Geoffrey; Zhou, Cong; Knopp, Jennifer L.; Möeller, Knut; Benyó, Balázs; Desaive, Thomas; Wong, Jennifer; Malinen, Sanna; Näswall, Katharina; Lambermont, Bernard; Chiew, Yeong Shiong

doi:10.1002/9781119857433.ch17

Cited by 6 publications

(1 citation statement)

References 244 publications

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“…Recently, there has been a surge in developing digital twins or virtual patients to facilitate personalized care and treatment. Lumped parameter models play a significant role in creating digital twins, enabling seamless integration of multiple organ systems to mimic the most pertinent physiological processes in real-time [4].…”

Section: Introductionmentioning

confidence: 99%

Comparing physiological impacts of positive pressure ventilation versus self-breathing via a versatile cardiopulmonary model incorporating a novel alveoli opening mechanism

Cabeleira,

Anand,

Ray

et al. 2024

Preprint

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Mathematical models can be used to generate high-fidelity simulations of the cardiopulmonary system. Such models, when applied to real patients, can provide valuable insights into underlying physiological processes that are hard for clinicians to observe directly. In this work, we propose a novel modelling strategy capable of generating scenario-specific cardiopulmonary simulations to replicate the vital physiological signals clinicians use to determine the state of a patient. This model is composed of a tree-like pulmonary system that features a novel, non-linear alveoli opening strategy, based on the dynamics of balloon inflation, that interacts with the cardiovascular system via the thorax. A baseline simulation of the model is performed to measure the response of the system during spontaneous breathing which is subsequently compared to the same system under mechanical ventilation. To test the new lung opening mechanics and systematic recruitment of alveolar units, a positive end-expiratory pressure (PEEP) test is performed and its results are then compared to simulations of a deep spontaneous breath. The system displays a marked decrease in tidal volume as PEEP increases, replicating a sigmoidal curve relationship between volume and pressure. At high PEEP, cardiovascular function is shown to be visibly impaired, in contrast to the deep breath test where normal function is maintained.

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Section: Introductionmentioning

confidence: 99%