COVID-19 crisis has enabled most tertiary institutions as well as business organizations worldwide to search for other means of imparting knowledge to students as well as carrying out business activities. This has given rise to both smart working and distance learning. This transformation process faces a number of complexities from both institutions and business organizations. Putting these aside, it has also generated opportunities for entrepreneurs to be innovative in pursuing infopreneurial activities by functioning maximally well within the distance learning domain. Distance learning has created opportunities to enhance the education system and prepare the learners for potential future emergencies. Smart working on the other hand, has enabled organizations to carry out businesses anywhere and everywhere. This chapter therefore, examined the entrepreneurial and innovative opportunities of smart working and distance learning within a developing country perspective with implications for practice, society and policies