Digital Solutions to Diagnose and Manage Postbariatric Hypoglycemia

Schönenberger, Katja A.; Cossu, Luca; Prendin, Francesco; Cappon, Giacomo; Wu, Jing; Fuchs, Klaus; Mayer, Simon; Herzig, David; Facchinetti, Andrea; Bally, Lia

doi:10.3389/fnut.2022.855223

Cited by 6 publications

(3 citation statements)

References 71 publications

(69 reference statements)

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“…на 8 пациентах, подверженных постбариатрической гипогликемии и подключенных к непрерывному мониторингу гликемии. Использование приложения SNAQ в рамках консультирования по вопросам питания может быть многообещающей технологией, поскольку она устраняет необходимость в трудоемких и подверженных ошибкам дневниках питания, предоставляет информацию о потреблении пищи в режиме реального времени и позволяет персонализировать рекомендации [50].…”

Section: искусственный интеллект в контроле сдunclassified

Evolution of blood glucose self-monitoring technology

Suplotova,

Alieva

2023

Diabetes mellitus

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In 1838 G. Rees, a doctor from London (Guy's Hospital), for the first time isolated excess sugar from the blood serum of a patient with diabetes mellitus. Diagnosis of diabetes mellitus gradually developed. The next step was the understanding that regular monitoring of glucose levels by the patient himself is an integral part of diabetes mellitus therapy. The starting point of the technology for self-monitoring of diabetes mellitus was the determination of the sugar content in urine using chemical reactions. The method had no great clinical significance, it only indicated a progressive disease. The first Dextrostix blood glucose test strip (Ames-Mile's laboratories) was introduced in 1964. In 1970, the first automated blood glucose analysis system, the Ames Reflectance Meter (ARM), was created. Over time, the technology has been improved, accuracy, visibility, comfort, and an individual approach to glucometry have been formed. A new chapter was the development of remote technologies and the possibility of remote monitoring. More advanced data processing is now available in tabular and graphical form, with the calculation of 7-, 14-, 30-, and 90-day average glycemic values. A promising direction is the introduction of artificial intelligence in the management of diabetes mellitus.

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Section: искусственный интеллект в контроле сдunclassified

Evolution of blood glucose self-monitoring technology

Suplotova,

Alieva

2023

Diabetes mellitus

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“…Acarbose is an alpha-glycosidase inhibitor that functions to slow down the absorption of carbohydrates [14].…”

Section: Introductionmentioning

confidence: 99%

“…Other pharmacological interventions for treating symptoms of late DS include diazoxide. Its hyperglycemic activity is the result of an interplay with ATP-sensitive potassium channels found on the membrane of the pancreatic β cells [14]. This would allow sustained potassium efflux, thereby blocking the stimulation of the insulin release pathway.…”

Section: Introductionmentioning

confidence: 99%

Dumping Syndrome in Children: A Narrative Review

Al-Jafari¹,

Alrosan²,

Alkhawaldeh³

et al. 2023

Cureus

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Dumping syndrome (DS) is a typical side effect of stomach surgery, which includes cancer, non-cancer esophageal and gastric surgery, and bariatric surgery. It is marked by the fast evacuation of undigested food from the stomach into the small intestine, which causes a variety of symptoms. Early dumping symptoms include gastrointestinal symptoms such as stomach discomfort, diarrhea, and nausea, as well as vasomotor symptoms such as drowsiness and face flushing, and occur within the first hour following a meal. Late dumping symptoms appear one to three hours after a meal and are related to reactive hypoglycemia, resulting in hypoglycemia, sweating, palpitations, and confusion.Early dumping pathophysiology involves abnormalities in stomach structure and function, which result in rapid transit of stomach contents to the duodenum, insufficient digestion, and fluid transfers from the vascular compartment to the intestine. Late dumping occurs as a result of hyperinsulinemia caused by the fast passage of undigested foods to the gut. Symptom-based questionnaires and diagnostic testing such as plasma glucose measurement and stomach emptying studies can be used to confirm a diagnosis of DS.The primary approach to managing DS is dietary modifications, including eating smaller, more frequent meals and avoiding high glycemic index carbohydrates. Dietary supplements and medications may be used to slow down gastric emptying or control blood glucose levels. Pharmacological options include alphaglycosidase inhibitors, somatostatin analogs, glucagon-like peptide-1 analogs, and sodium-glucose cotransporter inhibitors. In severe cases, refractory to conservative measures, surgical interventions may be considered.DS can arise in children following gastric surgery for obesity or corrective surgery for congenital abnormalities. It is frequently misdiagnosed and can have serious implications, such as hypoglycemiarelated cognition deficits. Screening and early identification using glucose tolerance testing and continuous glucose monitoring (CGM) are critical in at-risk youngsters. Children's treatment techniques are similar to those used in adults, with dietary changes and medication therapies serving as the cornerstone of care.Overall, DS is a complex condition that requires a multidisciplinary approach to diagnosis and management. Further research is needed to improve understanding of its pathophysiology and optimize treatment strategies, particularly in children.This review aims to provide a well-rounded informative summary of the most recent literature on the underrecognized clinical and scientific aspects of DS among the children age group. It incorporates the quality of life, pathophysiology, diagnosis, prevalence, and treatment.

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