Digital Pulse Volume Based Endothelial Function Detector for Early Stage Formation of Atherosclerosis

Liu, An-Bang; Wu, Tsang-Chih; Lee, Chun‐Ho; Liu, Cyuan-Cin; Wu, Hsien‐Tsai

doi:10.1109/imtc.2008.4547287

Cited by 4 publications

(7 citation statements)

References 10 publications

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“…Peripheral microvascular endothelial function assessment has been proven to be effective in the RH-PAT studies; previous study [15][16][17] also proposed a method that assesses endothelial function by observing the change of waveform after the stimulation as well, that is, the PPG system. The PPG system uses an infrared sensor on the left index finger's microvascular bed; it extracts numerous digital volume pulse waveform to serve as a baseline (Area Basline ), then a pressure cuff is used on the left upper arm for occlusion for 4 min; this will cause endothelium cells to react and produce NO for vasodilatation.…”

Section: Vaso-dilatation Index For Ppg Systemmentioning

confidence: 99%

“…More importantly, peripheral arteries can adjust the blood flow automatically. In that way, the wave signals [15,16] from the PPG system's sensors will not reflect the vasodilatation index exactly. That is the reason why we used the proposed air pressure sensing system in this study.…”

Section: Vaso-dilatation Index For Ppg Systemmentioning

confidence: 99%

“…The baseline is defined as 20 sets of area under the curve of pulse waveform before the inflation, noted as Area Baseline , Area RH is definedas 20 sets of area under the curve of pulse waveform after 1 min of cuff deflation, then Eq. 1 is used for vasodilatation index calculation [15]. The monitor screen-shot are shown in Fig.…”

Section: Software Analysismentioning

confidence: 99%

“…In previous studies [15,16], using Photoplethysmography (PPG) to calculate the area under the curve of the waveform for assessing the function of endothelium cell has been proven to be highly correlated with the traditional PAT method. The area under the curve of finger digital volume pulse grossly represents the volume change of blood flow into this finger during each pulse [16].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Endothelial Function Using Arterial Pressure Signals

Lee

Liu

2009

J Sign Process Syst

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Peripheral arterial tonometry (PAT) is a useful method to assess endothelial function. Analysis of pulse wave amplitude with PAT during reactive hyperemia can be used to study peripheral vascular endothelial function very well. We had injected a specific nitric oxide (NO) synthesize inhibitor intra-arterially into five adult male rats to verify the validation of our proposed photoplethysmograpy (PPG) system for endothelial function assessment. However, the reproducibility was not good for the system applied for measuring fingertip peripheral arteries. Therefore, an air-pressure sensing system with the high reproducibility was developed for peripheral vascular endothelial function assessment. This study showed that the vasodilatation index measured with air-pressure sensing system correlated very well with that measured using peripheral arterial tonometry. In addition, only few minutes are needed for conducting a self endothelial function assessment at home. And, early self-monitoring of cardiovascular dysfunction and arterial stiffness can be easily and effectively achieved.

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Section: Vaso-dilatation Index For Ppg Systemmentioning

confidence: 99%

Section: Vaso-dilatation Index For Ppg Systemmentioning

confidence: 99%

Section: Software Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of Endothelial Function Using Arterial Pressure Signals

Lee

Liu

2009

J Sign Process Syst

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“…Rather it uses tonometry to sense the change of amplitude of arterial waveforms for assessing endothelial function. The correlation between coronary and peripheral microvascular endothelial function is well established, and in previous studies, using Photoplethysmography (PPG) [8] to calculate the area under the curve of the waveform for assessing the function of endothelium cell has been proven to be highly correlated with the traditional RH-PAT method. The area under the curve of finger digital volume pulse grossly represents the volume change of blood flow into this finger during each pulse [9].…”

Section: Introductionmentioning

confidence: 99%

Endothelium function assessment with radial pulse wave signals

Lee

et al. 2009

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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This study proposes a method of measuring vasodilatation via air pressure sensing to assess the function of endothelium cells. The vasodilatation index is calculated according to the change of area of waveform caused by stimulation to the blood vessels, and uses this index to reflect the function of endothelium cells; therefore, early self-monitoring of cardiovascular dysfunction and arterial stiffness can be easily and effectively achieved. Only a few minutes are needed for conducting a self endothelial function assessment. Furthermore, this study improves the high cost pressure sensors used in Reactive Hyperemia Peripheral Arterial Tonometry (RH-PAT) and its inconveniences. 30 test subjects with no previous cardiovascular disease record were included for testing the reproducibility of the instrument. It has been proven that the air pressure sensing method proposed in this study has higher reproducibility and practicality than the Photoplethysmography (PPG) system for assessing the function of endothelium cells.

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