Digital obstructive arterial disease can be detected by laser Doppler measurements with high sensitivity and specificity

Liedl, David; McCarter, Charlene; Shepherd, Roger F.J.; Gloviczki, Peter; McPhail, Ian R.; Rooke, Thom W.; Wennberg, Paul W.

doi:10.1016/j.jvs.2013.10.076

Cited by 8 publications

(9 citation statements)

References 15 publications

(21 reference statements)

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“…Existem várias técnicas diferentes que permitem a avaliação quantitativa e qualitativa da perfusão cutânea, embora técnicas ópticas sejam geralmente preferidas devido à sua simplicidade. Entre estas, a fluxometria por laser Doppler (FLD) tem gozado de considerável sucesso desde há várias décadas (6) . Recentemente, avanços técnicos variando desde um aumento de sensibilidade a uma redução de custo deu um novo interesse à fotopletismografia (FPG) (7) .…”

Section: Methodsunclassified

“…There are several different techniques that allow quantitative and qualitative assessment of skin perfusion, although optical techniques are commonly preferred due to their simplicity. Among these, laser Doppler flowmetry (LDF) has been broadly used for several decades (6) . Recently, technical advances ranging from higher sensibility to reduced instrument (?)…”

Section: Introductionmentioning

confidence: 99%

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Comparing the spectral components of laser Doppler flowmetry and photoplethysmography signals for the assessment of the vascular response to hyperoxia

Silva

Bento

Vieira

et al. 2017

BBR

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Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c aComparing the spectral components of laser Doppler flowmetry and photoplethysmography signals for the assessment of the vascular response to hyperoxia AbstractThe skin is an ideal organ to record complex vascular signals, with laser Doppler flowmetry (LDF) and photoplethysmography (PPG) being commonly used quantification techniques. Hyperoxia is a common provocation stimulus, although many questions remain unanswered regarding its effect on microcirculation. In recent years much attention has been given to the mathematical modelling of physiological signals, with component analysis being a common approach. We aimed to characterize the LDF and PPG spectral profiles using wavelet transform (WT) to evaluate their components' response to a 100% oxygen provocation on skin microcirculation. We recorded LDF and PPG signals from the toes of 10 healthy subjects (20.5 ± 3.1 years old, after giving informed consent) before, during and after breathing an atmosphere of 100% oxygen. Signals were decomposed in their main components with the WT. Six components were identified in both signals (cardiac, respiratory, myogenic, sympathetic, endothelial NOdependent and endothelial NO-independent) in identical spectral positions. The cardiac, respiratory and myogenic activities increased during hyperoxia in both signals, while endothelial activities gave different responses. These discrepancies suggest that these techniques measure different phenomena and, therefore, may not be entirely interchangeable. These results reinforce the usefulness of WT in decomposing complex physiological signals.Keywords: component analysis, wavelet transform, physiological signal, LDF, PPG. ResumoA pele é um órgão ideal para gravar sinais vasculares complexos, sendo a fluxometria por laser Doppler (FLD) e a fotopletismografia (FPG) técnicas de quantificação vulgarmente utilizadas. A hiperóxia é um estímulo de provocação comumente utilizado, embora muitas questões permaneçam sem resposta quanto ao seu efeito sobre a microcirculação. Nos últimos anos muita atenção tem sido dada à modelação matemática de sinais fisiológicos, sendo a análise de componentes uma abordagem comum. O nosso objetivo foi o de caracterizar os perfis espectrais de FDL e FPG usando a transformada de wavelet (TW) para avaliar a resposta dos seus componentes a uma provocação de oxigénio a 100% sobre a microcirculação da pele. Foram registados sinais de FLD e FPG nos dedos dos pés de 10 indivíduos saudáveis (20,5 ± 3,1 anos), após terem dado o seu consentimento informado, antes, durante e após a respiração de uma atmosfera de oxigénio a 100%. Os sinais foram decompostos nas suas componentes principais com a TW. Seis componentes foram identificadas em ambos os sinais (cardíaca, respiratória, miogénica, simpática, endotelial dependente de NO e endotelial independente de NO) em posições espectrais idênticas. As atividades cardíaca, respiratória e miogénica aum...

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Section: Methodsunclassified

Section: Introductionmentioning

confidence: 99%

Comparing the spectral components of laser Doppler flowmetry and photoplethysmography signals for the assessment of the vascular response to hyperoxia

Silva

Bento

Vieira

et al. 2017

BBR

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“…In our vascular center, LDF and LSCI are conducted routinely for digital artery disease diagnosis according to the previous literature. [ 5 , 6 ] In this patient, LDF measurements were performed on each finger: baseline skin blood flow (SBF) at room temperature and postwarming skin blood flow. LDF was indicative of digital obstructive artery disease (DOAD) when postwarming SBF was<206 arbitrary units (a.u.).…”

Section: Case Reportmentioning

confidence: 99%

Performance of noninvasive laser Doppler flowmetry and laser speckle contrast imaging methods in diagnosis of Buerger disease

et al. 2018

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“…Thermal provocation has been used in combination with skin blood flow measurement to assess a number of conditions including chronic spinal cord injury [1], digital obstructive arterial disease (DOAD) [2] and transplanted free flaps [3]. In these studies, the region of interest is warmed by placing it into a thermal box [2], immersing it into warm water [3] or using a heating element directly on the skin [1], and the subsequent changes in blood flow are measured by a laser Doppler flowmeter. Healthy skin will respond by vasodilation leading to an increase in blood flow, while suboptimal or pathological skin may initiate a much smaller increase.…”

Section: Introductionmentioning

confidence: 99%

“…Healthy skin will respond by vasodilation leading to an increase in blood flow, while suboptimal or pathological skin may initiate a much smaller increase. It is believed that there are at least two factors which may affect the magni-tude of the thermal response: (1) the obstruction of the vasculature as in the case of DOAD [2], and (2) the disruption of the sympathetic pathways as in the case of spinal cord injury [1] and transplanted free flaps [3].…”

Section: Introductionmentioning

confidence: 99%

Validation of a Hybrid Microwave-Optical Monitor to Investigate Thermal Provocation in the Microvasculature

Al-Armaghany

Tong

Highton

et al. 2016

Advances in Experimental Medicine and Biology

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We have previously developed a hybrid microwave-optical system to monitor microvascular changes in response to thermal provocation in muscle. The hybrid probe is capable of inducing deep heat from the skin surface using mild microwaves (1-3 W) and raises the tissue temperature by a few degrees Celsius. This causes vasodilation and the subsequent increase in blood volume is detected by the hybrid probe using near infrared spectroscopy. The hybrid probe is also equipped with a skin cooling system which lowers the skin temperature while allowing microwaves to warm up deeper tissues. The hybrid system can be used to assess the condition of the vasculature in response to thermal stimulation. In this validation study, thermal imaging has been used to assess the temperature distribution on the surface of phantoms and human calf, following microwave warming. The results show that the hybrid system is capable of changing the skin temperature with a combination of microwave warming and skin cooling. It can also detect thermal responses in terms of changes of oxy/deoxy-hemoglobin concentrations.

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Digital obstructive arterial disease can be detected by laser Doppler measurements with high sensitivity and specificity

Abstract: LDF combined with a thermal challenge is highly accurate, safe, and noninvasive means to detect DOAD.

Cited by 8 publications

References 15 publications

Comparing the spectral components of laser Doppler flowmetry and photoplethysmography signals for the assessment of the vascular response to hyperoxia

Comparing the spectral components of laser Doppler flowmetry and photoplethysmography signals for the assessment of the vascular response to hyperoxia

Performance of noninvasive laser Doppler flowmetry and laser speckle contrast imaging methods in diagnosis of Buerger disease

Validation of a Hybrid Microwave-Optical Monitor to Investigate Thermal Provocation in the Microvasculature

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