Digital micromirror device based ophthalmoscope with concentric circle scanning

Damodaran, Mathi; Vienola, Kari V.; Braaf, Boy; Vermeer, Koenraad A.; Boer, Johannes F. de

doi:10.1364/boe.8.002766

Cited by 12 publications

(9 citation statements)

References 28 publications

(37 reference statements)

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“…The second generation system was built to address the shortcomings of the first system [10]. Parallel illumination scheme was still used but the parallel lines were replaced with concentric circles to help with the subject's fixation.…”

Section: In Vivo Imaging With the 2nd Generation Systemmentioning

confidence: 99%

Parallel line scanning ophthalmoscope for retinal imaging

Vienola¹,

Damodaran²,

Braaf³

et al. 2015

Opt. Lett.

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Section: In Vivo Imaging With the 2nd Generation Systemmentioning

confidence: 99%

Parallel line scanning ophthalmoscope for retinal imaging

Vienola¹,

Damodaran²,

Braaf³

et al. 2015

Opt. Lett.

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“…Spatial°exibility and programmability of DMD has improved the system in terms of speed and imaging precision. A single line scanning module is based on DMD incorporated in a nonmydriatic confocal retinal imaging system by Muller et al 74 In another publication by Vienola et al, 75 the team developed a ophthalmoscope based on DMD to compensate for eye movement. 76 The optical system used an LED with a bandwidth of 30 nm and a center wavelength of 810 nm as a light source and a DMD with a 0.7 inch diagonal micromirror array as the spatial light modulator, as shown in Fig 10. DMD was used for generating concentric circles in the illumination pattern.…”

Section: Application Of Dmd In Ophthalmoscopementioning

confidence: 99%

“…(b) The optical paths and beam shapes at di®erent positions in the setup to block the corneal re°ection. 75 illumination light e±ciency using a DMD, one has to increase the¯ll factor, which is still a challenging task. 77,78 In 2018, Kari et al 79 studied in vivo motion tracing in di®erent Scanning laser ophthalmoscopy SLO 76,78 for high-speed¯xational eye detection adopting DMD 80 at 130 Hz, reaching a motion detection bandwidth of 65 Hz.…”

Section: Application Of Dmd In Ophthalmoscopementioning

confidence: 99%

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Application of digital micromirror devices (DMD) in biomedical instruments

Zhuang

2020

J. Innov. Opt. Health Sci.

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There is an ongoing technological revolution in the field of biomedical instruments. Consequently, high performance healthcare devices have led to remarkable economic developments in the medical hardware industry. Until now, nearly all optical bio-imaging systems are based on the 2-dimensional imaging chip architecture. In fact, recent developments in digital micromirror devices (DMDs) are gradually making their way from conventional optical projection displays into biomedical instruments. As an ultrahigh-speed spatial light modulator, the DMD may offer a range of new applications including real-time biomedical sensing or imaging, as well as orientation tracking and targeted screening. Given its short history, the use of DMD in biomedical and healthcare instruments has emerged only within the past decade. In this paper, we first provide an overview by summarizing all reported cases found in the literature. We then critically analyze the general pros and cons of using DMD, specifically in terms of response speed, stability, accuracy, repeatability, robustness, and degree of automation, in relation to the performance outcome of the designated instrument. Particularly, we shall focus our discussion on the use of Micro-Electro-Mechanical System (MEMS)-based devices in a set of representative instruments including the surface plasmon resonance biosensor, optical microscopes, Raman spectrometers, ophthalmoscopes, and the micro stereolithographic system. Finally, the prospects of using the DMD approach in biomedical or healthcare systems and possible next generation DMD-based biomedical devices are presented.

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“…A multiwavelength SLO [43][44][45][46] was developed for the continuous acquisition of en face images of a phantom retina as shown in Fig. 9.…”

Section: Scanning Laser Ophthalmoscope-description Of the Systemmentioning

confidence: 99%

Optimal wavelengths for subdiffuse scanning laser oximetry of the human retina

2018

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Retinal blood vessel oxygenation is considered to be an important marker for numerous eye diseases. Oxygenation is typically assessed by imaging the retinal vessels at different wavelengths using multispectral imaging techniques, where the choice of wavelengths will affect the achievable measurement accuracy. Here, we present a detailed analysis of the error propagation of measurement noise in retinal oximetry, to identify optimal wavelengths that will yield the lowest uncertainty in saturation estimation for a given measurement noise level. In our analysis, we also investigate the effect of hemoglobin packing in discrete blood vessels (pigment packaging), which may result in a nonnegligible bias in saturation estimation if unaccounted for under specific geometrical conditions, such as subdiffuse sampling of smaller blood vessels located deeper within the retina. Our analyses show that using 470, 506, and 592 nm, a fairly accurate estimation of the whole oxygen saturation regime [0 1] can be realized, even in the presence of the pigment packing effect. To validate the analysis, we developed a scanning laser ophthalmoscope to produce high contrast images with a maximum pixel rate of 60 kHz and a maximum 30-deg imaging field of view. Confocal reflectance measurements were then conducted on a tissue-mimicking scattering phantom with optical properties similar to retinal tissue including narrow channels filled with absorbing dyes to mimic blood vessels. By imaging at three optimal wavelengths, the saturation of the dye combination was calculated. The experimental values show good agreement with our theoretical derivations.

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Digital micromirror device based ophthalmoscope with concentric circle scanning

Cited by 12 publications

References 28 publications

Parallel line scanning ophthalmoscope for retinal imaging

Parallel line scanning ophthalmoscope for retinal imaging

Application of digital micromirror devices (DMD) in biomedical instruments

Optimal wavelengths for subdiffuse scanning laser oximetry of the human retina

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