Digital Light 3D Printed Bioresorbable and NIR‐Responsive Devices with Photothermal and Shape‐Memory Functions

Paunović, Nevena; Marbach, Jessica; Bao, Yinyin; Berger, Valentine; Klein, Karina; Schleich, Sarah; Coulter, Fergal B.; Kleger, Nicole; Studart, André R.; Franzen, Daniel; Luo, Zhi; Leroux, Jean‐Christophe

doi:10.1002/advs.202200907

Cited by 30 publications

(23 citation statements)

References 77 publications

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“…Similarly, Immediate release tablets were fabricated using this technique to release Zolpidem tartrate ( 21 ). The same technique was also used to develop medical devices that have photothermal and shape memory functions ( 22 ).…”

Section: Types Of 3d Printingmentioning

confidence: 99%

3D printing of pharmaceuticals for disease treatment

Chakka

Chede

2023

Front. Med. Technol.

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Three-dimensional (3D) printing or Additive manufacturing has paved the way for developing and manufacturing pharmaceuticals in a personalized manner for patients with high volume and rare diseases. The traditional pharmaceutical manufacturing process involves the utilization of various excipients to facilitate the stages of blending, mixing, pressing, releasing, and packaging. In some cases, these excipients cause serious side effects to the patients. The 3D printing of pharmaceutical manufacturing avoids the need for excessive excipients. The two major components of a 3D printed tablet or dosage form are polymer matrix and drug component alone. Hence the usage of the 3D printed dosage forms for disease treatment will avoid unwanted side effects and provide higher therapeutic efficacy. With respect to the benefits of the 3D printed pharmaceuticals, the present review was constructed by discussing the role of 3D printing in producing formulations of various dosage forms such as fast and slow releasing, buccal delivery, and localized delivery. The dosage forms are polymeric tablets, nanoparticles, scaffolds, and films employed for treating different diseases.

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Section: Types Of 3d Printingmentioning

confidence: 99%

3D printing of pharmaceuticals for disease treatment

Chakka

Chede

2023

Front. Med. Technol.

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“…To realize the highly efficient photo switchable 4D printing, inorganic oxide semiconducting nanoparticles were chosen due to their inherent stability at high temperatures required during transformation 18 . Even nanomaterials, such as carbon nanotubes 30 , graphene 31 , black phosphorus 32 , and precious metals 33 , have been used for 4D printing shape morphing structures, they do not exhibit photo switching ability.…”

Section: Photo Switchable Wo 29 Nanoparticlesmentioning

confidence: 99%

Photo switchable 4D printing remotely controlled responsive and mechanically robust shape memory polymer nanocomposites

Zhang

Feng

Peng

et al. 2023

Preprint

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Photo-triggered shape morphing structures can be found in myriads of areas. Utilizing light as a switch can effectively control and regulate the precise deformation of structures. However, the integration of photo switching functions in shape morphing structures with complex geometries remains a challenge. Here, we report photo switchable digital light processing based 4D printing high-resolution and highly complex geometries, based on UV curable WO2.9 nanoparticle doped shape memory polymer nanocomposites, which are highly deformable (stretchability up to ~1000% at rubbery state) and fatigue resistant (repeatedly loaded > 1200 times at ambient temperature). The presence of just trace WO2.9 nanoparticles (< 0.20 wt.‰) contributes to the controlled photothermal property of nanocomposite via selective absorption of light, which enables reversibly photo switchable (＞50 times), spatial and remote control of 4D printing shape morphing structures. These findings offer a promising approach to expanding the applications of photo-triggered shape morphing structures.

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“…This type of material is of special interest in the printing of parts that require optical clarity but, at the same time, can find enhanced properties by the inclusion of a remotely activated function, such as shape memory, self-healing, or thermal control. For instance, Paunović and collaborators have applied DLP technology to resins modified with Au nanorods for the fabrication of therapeutic devices with NIR light-triggerable shape transformation . Printing of parts with a high level of transmittance or optical clarity is an interesting possibility to explore, for example, in the printing of microfluidic devices, aesthetic prosthetics, biomedical tools, works of art, and other types of objects in which conservation of a high degree of transparency and a small level of coloration could be desirable.…”

Section: Introductionmentioning

confidence: 99%

Stable Photopolymerizable Resins Modified with Functionalized Silica-Coated Gold Nanostructures for the Fabrication of Optically Clear 3D Objects with Remote Photothermal Activation

Penelas,

Schroeder,

Arenas

et al. 2024

ACS Appl. Polym. Mater.

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A compatibilization strategy, based on the synthesis of methacrylate-functionalized gold core−silica shell nanostructures, was used for the formulation of stable, optically clear, printable, and photothermally responsive methacrylate resins. The rational design of the shell enclosing the metallic core was shown to be crucial to achieve clear products with long-term stability against aggregation, of paramount importance in the design of long shelf life photopolymerizable resins. These modified hybrid resins were used for the fabrication of films and 3D objects using a visible-light photopolymerization approach with a 405 nm laser, the common wavelength used in resin additive manufacturing by optical stereolithography (SLA) and digital light processing (DLP). Functionalization of the core−shell nanoparticles (NP) with methacrylate groups additionally enables the immobilization of plasmonic nanostructures through covalent bonding to the polymer network, which is useful to prevent their leaking and diffusion during the service life cycle of the printed parts. The as-produced, faintly colored polymeric objects showed a significant photothermal effect under visible-light irradiation, with a recorded temperature enhancement of more than 80 °C in 1 min for formulations containing 84 μg of Au/g of resin under a laser power of 700 mW. The heat generated by these NPs was used to remotely and locally activate the shape memory behavior of clear bars printed with a commercial acrylic resin, demonstrating the applicability of these structures for the modification of general purpose resins and monomers. Hence, the proposed strategy shows to be a promising tool for the design of photopolymerizable resins but also for the modification of products already available in the market, with applications in the fabrication of functional objects by 3D photoprinting techniques.

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Digital Light 3D Printed Bioresorbable and NIR‐Responsive Devices with Photothermal and Shape‐Memory Functions

Cited by 30 publications

References 77 publications

3D printing of pharmaceuticals for disease treatment

3D printing of pharmaceuticals for disease treatment

Photo switchable 4D printing remotely controlled responsive and mechanically robust shape memory polymer nanocomposites

Stable Photopolymerizable Resins Modified with Functionalized Silica-Coated Gold Nanostructures for the Fabrication of Optically Clear 3D Objects with Remote Photothermal Activation

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