OBJECTIVE -The aim was to evaluate over 18 months whether depression was associated with mortality in people with their first foot ulcer.
RESEARCH DESIGN AND METHODS -A prospective cohort design was used.Adults with their first diabetic foot ulcer were recruited from foot clinics in southeast London, U.K. At baseline, the Schedules for Clinical Assessment in Neuropsychiatry 2.1 was used to define those who met DSM (Diagnostic and Statistical Manual of Mental Disorders)-IV criteria for minor and major depressive disorders. Potential covariates were age, sex, marital status, socioeconomic status, smoking, antidepressant use, A1C, macro-and microvascular complications, and University of Texas classification-based severity and size of ulcer. The main outcome was mortality 18 months later, and A1C was the secondary outcome. The proportion who had an amputation, had recurrence, and whose ulcer had healed was recorded.RESULTS -A total of 253 people with their first diabetic foot ulcer were recruited. The prevalence of minor and major depressive disorder was 8.1% (n ϭ 21) and 24.1% (n ϭ 61), respectively. There were 40 (15.8%) deaths, 36 (15.5%) amputations, and 99 (43.2%) recurrences. In the adjusted Cox regression analysis, minor and major depressive disorders were associated with an approximately threefold hazard risk for mortality compared with no depression (3.23 [95% CI 1.39 -7.51] and 2.73 [1.38 -5.40], respectively). There was no association between minor and major depression compared with no depression and A1C (P ϭ 0.86 and P ϭ 0.43, respectively).CONCLUSIONS -One-third of people with their first diabetic foot ulcer suffer from clinical depression, and this is associated with increased mortality.
Diabetes Care 30:1473-1479, 2007D iabetic foot ulcers are one of the most common, disabling, and costly complications of diabetes (1-3). The incidence and prevalence for foot ulcers is estimated at 2% and 5-7% per year, respectively (3,4). Duration of diabetes, persistent hyperglycemia, and peripheral neuropathy (associated with reduced pain sensation) are considered to be well-known biological risk factors for the onset and recurrence of foot ulcers (5-7). Primary and secondary prevention of diabetic foot ulcers can be achieved by daily foot examinations for painless ulcers or injuries, regular podiatrist visits, use of appropriate foot wear, and maintenance of optimal diabetes self-care (8). Despite this, adverse outcomes following the onset of foot ulcers are poor, and they are the most common reason for amputation (9).The rate of recurrence of foot ulcers is estimated at 34, 61, and 70% in 1, 3, and 5 years, respectively (1). Around 15% develop osteomyelitis, and there is a twofold increase in mortality compared with people with diabetes without a foot ulcer (3, 10,11). Could psychological factors such as depressive disorders help to explain the high rates of mortality and morbidity?The pooled prevalence of depressive disorders in people with diabetes when diagnostic criteria are used is estimated at 11%, which is ...