Digital Health Interventions to Enhance Tuberculosis Treatment Adherence: Scoping Review

Lee, Sol; Rajaguru, Vasuki; Baek, Joon Sang; Shin, Jaeyong; Park, Youngmok

doi:10.2196/49741

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…Digital health solutions: The integration of digital health solutions, such as mobile applications and cloudbased platforms, could streamline the data management and reporting aspects of tuberculosis diagnostics. This could improve real-time surveillance, data sharing, and connectivity between diagnostic facilities [43,44].…”

Section: Potential Future Developments In Tuberculosis Diagnosticsmentioning

confidence: 99%

Advancements in Tuberculosis Diagnostics: A Comprehensive Review of the Critical Role and Future Prospects of Xpert MTB/RIF Ultra Technology

Yadav,

Rawal,

Jeyaraman

et al. 2024

Cureus

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Tuberculosis remains a persistent global health challenge, demanding swift and accurate diagnostic methods for effective treatment. The emergence of the Xpert MTB/RIF Ultra system marks a significant milestone in combating tuberculosis, streamlining the identification of Mycobacterium tuberculosis , and advancing our pursuit of eradicating the disease. Delving into the therapeutic landscape of tuberculosis and rifampicin resistance, this scientific narrative review offers a comprehensive exploration. It begins by delving into the historical backdrop and the hurdles encountered with traditional tuberculosis diagnostics. From there, it traces the journey of the Xpert MTB/RIF technology, underscoring its molecular underpinnings. In this narrative review, the performance of the Xpert MTB/RIF Ultra system undergoes thorough scrutiny, encompassing investigations into sensitivity, specificity, and comparisons with alternative diagnostic methods. The spotlight shines on its clinical applications across diverse scenarios, from diagnosing pulmonary and extrapulmonary tuberculosis to its pivotal role in identifying rifampicin resistance. The study also evaluates its clinical efficacy in enhancing patient outcomes and supporting global tuberculosis control initiatives. However, the review does not shy away from discussing the challenges and limitations associated with the Xpert MTB/RIF Ultra system. It meticulously addresses concerns regarding cost, infrastructure requirements, and potential diagnostic inaccuracies. Offering a panoramic view, the review assesses the system's impact in resource-constrained settings and its potential to bolster tuberculosis elimination endeavors worldwide. Peering into the future, it explores ongoing research avenues and potential enhancements in Xpert MTB/RIF Ultra technology, envisioning a landscape of improved performance, broader applications, and emerging diagnostic innovations in the realm of tuberculosis diagnostics.

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Section: Potential Future Developments In Tuberculosis Diagnosticsmentioning

confidence: 99%

Advancements in Tuberculosis Diagnostics: A Comprehensive Review of the Critical Role and Future Prospects of Xpert MTB/RIF Ultra Technology

Yadav,

Rawal,

Jeyaraman

et al. 2024

Cureus

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Identification of the health education targeted susceptible population of tuberculosis in Ningxia, Northwest China

Ma,

Chen,

Ding

et al. 2024

Sci Rep

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Knowledge, Attitude, and Practice (KAP) survey, as an effective measure tool, is of practical significance for identifying the susceptible population in high-incidence regions of tuberculosis (TB). We aim to identify the health education targeted susceptible population of TB and discuss the acting pathway of KAP in Ningxia. A multistage random sampling method was used to conduct a face-to-face questionnaire survey for residents. The latent class analysis (LCA) model was used to classify susceptible populations of TB, and the structural equation modeling (SEM) model was also employed to investigate the interaction mechanisms of KAP (mediation analysis). We further applied the ordered logistic regression model to explore the associated factors. A total of 973 residents were enrolled, 70.6% were male, aged from 16 to 89. The LCA analysis demonstrated that 3 categories of susceptible populations of TB ("overall good", "positive attitude" and "overall poor") have optimal goodness of fit (BIC = 7889.5, Entropy = 0.923). SEM model indicated that the attitude plays a significant mediation effect from knowledge to practice toward TB (an indirect effect of 0.038, and a direct effect of 0.138). The ordered logistic regression results found that age, sex, marital status, education level, occupation, family income, self-perceived health status, having a family member or friend with TB, and knowing the DOTS strategy were significantly associated with classifications of KAP level towards TB. Based on the LCA model, we accurately classified the susceptible population of TB into 3 groups with different degrees of KAP. We found that TB attitude plays a mediating role between knowledge and practice. Therefore, we should pay more attention and carry out targeted health education in the community to these populations with overall poor KAP towards TB, and develop effective strategies and measures to realize the End TB Plan.

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Effectiveness of a Multifaceted Mobile Health Intervention (Multi-Aid-Package) in Medication Adherence and Treatment Outcomes Among Patients With Hypertension in a Low- to Middle-Income Country: Randomized Controlled Trial

Arshed,

Mahmud,

Minhat

et al. 2024

JMIR Mhealth Uhealth

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Background:The high prevalence of uncontrolled hypertension in Pakistan is predominantly attributed to poor drug adherence. Mobile phone innovations are cheap, ubiquitous, and culturally acceptable tools for behavioral change. As more than 137 million populations in Pakistan use mobile phones, a suitable mobile health (mHealth) module can be a suitable and effective tool to overcome poor drug adherence.Objective: This study sought to determine whether a novel mobile health intervention was useful in enhancing adherence to antihypertensive therapy and treatment outcomes among patients with hypertension in a developing country. Methods:A parallel, single-blinded, superiority randomized controlled trial of six months duration recruited 439 hypertensive patients at a public hospital in Pakistan, with poor adherence to antihypertensive therapy and access to smartphones. An innovative multifaceted, mHealth intervention, "Multi-Aid-Package", based on the Health Belief Model was developed for the intervention group. The novel module contained written, audio & visual reminders, infographics, video clips, educational content, and 24/7 individual support, while the control group only received standard care. The primary outcome was selfreported medication adherence measured using the Self-efficacy for Appropriate Medication Adherence Scale (SEAMS) and pillcounting. The secondary outcome was a systolic blood pressure (SBP) change. Both outcomes were evaluated at the baseline and 6 months. Technology acceptance feedback was also assessed at the end of the study.Results: Of 439 participants, 423 could complete the study. In the control group, 10 participants were lost to follow-up, while one withdrew his consent. In the intervention group, 6 participants were lost to follow-up. At six months post-intervention, the median SEAMS score was higher in the intervention group (32, IQR 11) compared to the controls (21, IQR 6), and the difference was statistically significant (P<0.001). Within the intervention group, there was also an improvement of 12.5 points between baseline and 6 months (P<0.001). By using the pill-counting method, there was an increase in adherent patients between the intervention and the control groups (difference of 81 patients, P<0.001), as well as within groups (difference of 83 patients; baseline vs 6 months, P<0.001). As for the SBP, between groups, there was a statistically significant difference in SBP of 7mmHg (P<0.001) at 6 months, while within groups, there was a reduction by 4mmHg (P<0.001) within the intervention group, but there was an increase by 3mmHg (P=0.314) in the controls. Overall, the number of patients with uncontrolled hypertension was reduced by 46 patients in the intervention group (baseline vs 6 months), but the controls remained unchanged. The Multi-Aid-Package received a 94.8% acceptability score. Conclusions:The novel "Multi-Aid-Package" is an effective mHealth module in enhancing adherence to medication and treatment outcomes among patients with hypertension in a developing country. C...

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Digital Health Interventions to Enhance Tuberculosis Treatment Adherence: Scoping Review

Cited by 3 publications

References 44 publications

Advancements in Tuberculosis Diagnostics: A Comprehensive Review of the Critical Role and Future Prospects of Xpert MTB/RIF Ultra Technology

Advancements in Tuberculosis Diagnostics: A Comprehensive Review of the Critical Role and Future Prospects of Xpert MTB/RIF Ultra Technology

Identification of the health education targeted susceptible population of tuberculosis in Ningxia, Northwest China

Effectiveness of a Multifaceted Mobile Health Intervention (Multi-Aid-Package) in Medication Adherence and Treatment Outcomes Among Patients With Hypertension in a Low- to Middle-Income Country: Randomized Controlled Trial

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