Digital gene atlas of neonate common marmoset brain

Shimogori, Tomomi; Abe, Ayumi; Go, Yasuhiro; Hashikawa, Tsutomu; Kishi, Noriyuki; Kikuchi, Shunsuke; Kita, Yoshiaki; Niimi, Kimie; Nishibe, Hirozumi; Okuno, Masanari; Saga, Kanako; Sakurai, Miyano; Sato, Masae; Serizawa, Tsuna; Suzuki, Shunji; Takahashi, Eiki; Tanaka, Mami; Tatsumoto, Shoji; Toki, Mitsuhiro; Mami, U; Wang, Yan; Windak, Karl J.; Yamagishi, Haruhiko; Yamashita, Keiko; Yoda, Tomoko; Yoshida, Aya; Yoshida, Chihiro; Yoshimoto, Taichiro; Okano, Hideyuki

doi:10.1016/j.neures.2017.10.009

Cited by 43 publications

(50 citation statements)

References 47 publications

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“…We used the Marmoset Gene Atlas to examine the expression of SOX14 and OTX2 , known markers for the mouse dLGN interneurons (Golding et al, 2014; Jager et al, 2016; DropViz), in the early postnatal marmoset thalamus. These were then compared to the GAD1 signal (all ISH data available from: https://gene-atlas.brainminds.riken.jp; Shimogori et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

Dual midbrain and forebrain origins of thalamic inhibitory interneurons

Jager

Moore

Calpin

et al. 2019

Preprint

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12The proportion and distribution of local inhibitory neurons (interneurons) in the thalamus 13 varies widely across mammals. This is reflected in the structure of thalamic local circuits, 14which is more complex in primates compared to smaller-brained mammals like rodents. 15An increase in the number of thalamic interneurons could arise from addition of novel 16 interneuron types or from elaboration of a plesiomorphic ontogenetic program, common to 17 all mammals. The former has been proposed for the human brain, with migration of 18 interneurons from the ventral telencephalon into higher order thalamus as one of its unique 19 features (Letinic and Rakic, 2001). 20Here, we identify a larger than expected complexity and distribution of interneurons across 21 the mouse thalamus. All thalamic interneurons can be traced back to two developmental 22 programs: one specified in the midbrain and the other in the forebrain. Interneurons migrate 23 to functionally distinct thalamic nuclei, where the midbrain-derived cells populate the sensory 24 thalamus, and forebrain-generated interneurons only the higher order regions. The latter 25 interneuron type may be homologous to the one previously considered to be human-specific, 26while we also observe that markers for the midbrain-born class are abundantly expressed in 27 the primate thalamus. These data therefore point to a shared ontogenetic organization of 28 thalamic interneurons across mammals. 29 30

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Section: Resultsmentioning

confidence: 99%

Dual midbrain and forebrain origins of thalamic inhibitory interneurons

Jager

Moore

Calpin

et al. 2019

Preprint

Self Cite

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“…To further determine whether the candidate patch-matrix markers displayed conserved expression patterns in non-human primates, we investigated the in situ expression in the corresponding dorsal striatum (i.e., the caudate and putamen) of the common marmoset (Callithrix jacchus) using the Marmoset Gene Atlas (Shimogori et al, 2018). For the available markers (patch markers: Tac1, Spon1, Tshz1, Lypd1; matrix marker: Epha4), we found that they all displayed the predicted spatial expression pattern, labeling putative patch and matrix compartments in the marmoset caudate and putamen ( Figure 3E)…”

Section: Molecular Classification Of Spns In Patch Exopatch and Matrixmentioning

confidence: 99%

A Spatiomolecular Map of the Striatum

et al. 2019

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“…To further determine whether the candidate patch-matrix markers displayed conserved expression patterns in non-human primates, we investigated the in situ expression in the corresponding dorsal striatum (i.e. the caudate and putamen) of the common marmoset (Callithrix jacchus) using the Marmoset Gene Atlas 29 . For the available markers (patch markers: Tac1, Spon1, Tshz1, Lypd1; matrix marker: Epha4), we found that they all displayed the predicted spatial expression pattern, labeling putative patch and matrix compartments in the marmoset caudate and putamen ( Fig.…”

Section: Molecular Classification Spns In Patch Exopatch and Matrixmentioning

confidence: 99%

A Spatiomolecular Map of the Striatum

Märtin

Calvigioni

Tzortzi

et al. 2019

Preprint

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The striatum is organized into two major outputs formed by striatal projection neuron (SPN) subtypes with distinct molecular identities. In addition, the histochemical division into patch and matrix compartments represents an additional spatial organization, proposed to mirror a functional specialization in a motor-motivation dimension. To map the molecular diversity of SPNs in the context of the patch and matrix division, we genetically labeled mu-opioid receptor (Oprm1) expressing striatal neurons and performed single-nucleus RNA sequencing (snRNA-seq). This allowed us to establish new molecular definitions of the patch-matrix compartments, resulting in a molecular code for mapping patch SPNs at the cellular level. In addition, Oprm1 expression labeled exopatch SPNs, which we found to be molecularly distinct from both patch as well as neighboring matrix SPNs, thereby forming a separate molecular entity. At the cell-type level, we found an unexpected SPN diversity, leading to the identification of a new Col11a1+ striatonigral SPN type. At the tissue level, we found that mapping the spatial expression of a number of markers revealed new definitions of spatial domains in the striatum, which were conserved in the non-human primate brain. Interestingly, the spatial markers were cell-type independent and instead represented a spatial code that was found across all SPNs within a spatially restricted domain. This spatiomolecular map establishes a formal system for targeting and studying the striatal subregions and SPNs subtypes, beyond the classical striatonigral and striatopallidal division.

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Digital gene atlas of neonate common marmoset brain

Cited by 43 publications

References 47 publications

Dual midbrain and forebrain origins of thalamic inhibitory interneurons

Dual midbrain and forebrain origins of thalamic inhibitory interneurons

A Spatiomolecular Map of the Striatum

A Spatiomolecular Map of the Striatum

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