Digital (Fingertip) Thermal Monitoring of Vascular Function: A Novel, Noninvasive, Nonimaging Test to Improve Traditional Cardiovascular Risk Assessment and Monitoring of Response to Treatments

Budoff, Matthew J.; Ahmadi, Naser; Kleis, Stanley J.; Akhtar, Wasy; McQuilkin, Gary L.; Gul, Khawar; O’Brien, Timothy J.; Jamieson, Craig; Hassan, Haider; Panthagani, David; Yen, Albert; Metcalfe, Ralph W.; Naghavi, Morteza

doi:10.1007/978-1-60327-179-0_18

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Another method, called Digital Thermal Monitoring (DTM), has been developed to measures peripheral vascular reactivity using reactive hyperaemia after increasing the blood pressure (BP) to suprasystolic values. The measurements using this instrument have excellent reproducibility and low variability 25 , demonstrate strong relationship with flow mediated dilation technique (FMD) 26 , coronary calcium score, myocardial perfusion defects, and coronary angiography 10,[27][28][29][30][31][32] and were validated for detecting ED and CVD risk 1, 10, 26, 30, 33 . In addition, similarly to DVA, DTM is also a non-invasive technique that can be performed in primary care settings, therefore, suitable for early screening. However, these two instruments assess vascular beds with different anatomical properties and exposed to different physiological influences 34,35 .…”

Section: Introductionmentioning

confidence: 97%

Retinal and peripheral vascular function in healthy individuals with low cardiovascular risk

Karimzad

Shokr

Gherghel

2019

Microvascular Research

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Section: Introductionmentioning

confidence: 97%

Retinal and peripheral vascular function in healthy individuals with low cardiovascular risk

Karimzad

Shokr

Gherghel

2019

Microvascular Research

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“…Ante esta situación han surgido nuevas técnicas diagnósticas que evalúan RV mediante HR en una extremidad (5,(8)(9)(10)(11)(12)(13)(14) , las cuales buscan un promisorio avance en la detección temprana de las ECV, sin embargo estos métodos se encuentran en estado de desarrollo y requieren validación y aceptación clínica.…”

Section: Introductionunclassified

Modelado del sistema cardiovascular para evaluación de técnicas de estimación de reactividad vascular basadas en hiperemia reactiva

2018

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Introducción: La evaluación de la Reactividad Vascular (RV) se hace mediante la respuesta hiperémica después de una isquemia producida por oclusión arterial. Existen técnicas de medición de RV que permiten evaluar la función vascular con menor costo y sin dependencia del operador, pero se encuentran en desarrollo y requieren validación y aceptación clínica. Objetivo: Modelar computacionalmente la mecánica vascular con el fin de evaluar el desempeño de una técnica de RV. Materiales y métodos: Se modificó el modelo eléctrico de la vasculatura del brazo, obteniendo el volumen periférico con y sin oclusión de la arteria braquial. Se realizó una identificación computacional que relaciona el volumen periférico con los resultados de una técnica de evaluación de RV que presenta cambios de color en la mano ocluida durante hiperemia reactiva. El software utilizado fue Matlab®. Resultados: El modelo modificado permitió obtener el volumen periférico con y sin oclusión representando la perfusión en la microvascultura. El modelo no lineal Hammerstein-Weiner fue el mejor descriptor de los cambios de color en función de la dinámica del sistema vascular y presentó porcentaje de ajuste promedio de 95,69%. Conclusiones: Es posible modelar computacionalmente la técnica de evaluación de la función vascular utilizando identificación no lineal.

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High Frequency of Microvascular Dysfunction in US Outpatient Clinics: A Sign of High Residual Risk? Data from 7,105 Patients

Naghavi

Kleis

Tanaka

et al. 2022

International Journal of Vascular Medicine

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Previous studies have linked peripheral microvascular dysfunction measured by arterial tonometry to high residual risk in on-statin patients. Digital thermal monitoring (DTM) of microvascular function is a new and simplified technique based on fingertip temperature measurements that has been correlated with the burden of atherosclerosis and its risk factors. Here, we report analyses of DTM data from two large US registries: Registry-I (6,084 cases) and Registry-II (1,021 cases) across 49 US outpatient clinics. DTM tests were performed using a VENDYS device during a 5-minute arm-cuff reactive hyperemia. Fingertip temperature falls during cuff inflation and rebounds after deflation. Adjusted maximum temperature rebound was reported as vascular reactivity index (VRI). VRI distributions were similar in both registries, with mean ± SD of 1.58 ± 0.53 in Registry-I and 1.52 ± 0.43 in Registry-II. In the combined dataset, only 18% had optimal VRI (≥2.0) and 82% were either poor (<1.0) or intermediate (1.0-2.0). Women had slightly higher VRI than men ( 1.62 ± 0.56 vs. 1.54 ± 0.47 , p < 0.001 ). VRI was inversely but mildly correlated with age ( r = − 0.19 , p < 0.001 ). Suboptimal VRI was found in 72% of patients <50 years, 82% of 50-70 years, and 86% of ≥70 years. Blood pressure was not correlated with VRI. In this largest registry of peripheral microvascular function measurements, suboptimal scores were highly frequent among on-treatment patients, possibly suggesting a significant residual risk. Prospective studies are warranted to validate microvascular dysfunction as an indicator of residual risk.

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Digital (Fingertip) Thermal Monitoring of Vascular Function: A Novel, Noninvasive, Nonimaging Test to Improve Traditional Cardiovascular Risk Assessment and Monitoring of Response to Treatments

Cited by 3 publications

References 23 publications

Retinal and peripheral vascular function in healthy individuals with low cardiovascular risk

Retinal and peripheral vascular function in healthy individuals with low cardiovascular risk

Modelado del sistema cardiovascular para evaluación de técnicas de estimación de reactividad vascular basadas en hiperemia reactiva

High Frequency of Microvascular Dysfunction in US Outpatient Clinics: A Sign of High Residual Risk? Data from 7,105 Patients

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