Low-frequency torsional resonance arising from large inertia load and elastic shaft causes vibration when industrial servo system is working, which degrades the system's performance of motion control. This paper presents an adjustable inertia ratio control strategy based on designing disturbance observer, which the inertia ratio between the load and rotor is adjusted to an optimal ratio so as to suppress the low-frequency disturbance to the motor output shaft and load simultaneously, this algorithm allows that the servo system controls the movement of large inertia load smoothly and steadily. The effectiveness of the proposed concept is demonstrated theoretical analysis and simulation.