Digital computer subroutine for the conversion of oxygen tension into saturation.

Kelman, G. R.

doi:10.1152/jappl.1966.21.4.1375

Cited by 484 publications

(226 citation statements)

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“…These predictions may be physiological or mathematical in nature, and predict SO 2 based on specific parameters, such as temperature and acid base status. Two such models are those of Severinghaus (1979) and Kelman (1966). The Severinghaus model is a modification of the Hill equation (1910), which describes the sigmoidal shape of the ODC for a given set of points that lie on a single ODC.…”

Section: In Vitro Methods Of Odc Measurement and Predictionmentioning

confidence: 99%

“…A number of models have therefore been created to predict saturation from more readily available arterial blood measures, such as PCO 2 , PO 2 and pH. The Kelman model (Kelman, 1966) uses PCO 2 , pH, and temperature to calculate a -virtual PO 2 ‖ (the PO 2 that would lead to the same saturation if measured under standard conditions of T, PCO 2 and pH), which is then used to predict SO 2 . This model was shown to be both reliable and valid at sea level (Breuer et al, 1989 …”

Section: Predicting Saturationmentioning

confidence: 99%

“…The other model that was used with our data is that of Kelman (1966). This model preceded that of Severinghaus.…”

Section: Kelman Somentioning

confidence: 99%

“…In order to determine how our in vivo SO 2 data compared to predictions based on previous in vitro studies, we then compared our in vivo SO 2 results to those calculated using the Severinghaus (1966) and Kelman (1966) methods. shown above.…”

Section: Comparison Of Measured So 2 Values With Those Of Severinghaumentioning

confidence: 99%

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The in-vivo oxyhaemoglobin dissociation curve at sea level and high altitude

Balaban

Duffin

Preiss

et al. 2013

Respiratory Physiology & Neurobiology

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Some animals have adapted to hypoxia by increasing their haemoglobin affinity for oxygen, but in vitro studies have not shown any change of haemoglobin affinity for oxygen in human high altitude natives or lowlanders acutely acclimatized to high altitude. We conducted the first in vivo study of the oxyhaemoglobin dissociation curve by progressively reducing arterial PO 2 while maintaining normocapnia in lowlanders at sea level, lowlanders sojourning at 3600m for two weeks and native Andeans at the same altitude. We found that the in vivo PO 2 at which haemoglobin is half-saturated (P 50 ) is higher in lowlanders at sea level (32 mmHg) than that measured in vitro (27 mmHg) and that lowlanders and highlanders do significantly increase the in vivo affinity of their haemoglobin for oxygen with exposure to high altitude. These results indicate the value of an in vivo approach for studying the oxyhaemoglobin dissociation curve.iii

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Section: In Vitro Methods Of Odc Measurement and Predictionmentioning

confidence: 99%

Section: Predicting Saturationmentioning

confidence: 99%

“…The other model that was used with our data is that of Kelman (1966). This model preceded that of Severinghaus.…”

Section: Kelman Somentioning

confidence: 99%

Section: Comparison Of Measured So 2 Values With Those Of Severinghaumentioning

confidence: 99%

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The in-vivo oxyhaemoglobin dissociation curve at sea level and high altitude

Balaban

Duffin

Preiss

et al. 2013

Respiratory Physiology & Neurobiology

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“…To determine the ideal oxygen saturation in the lung capillaries, the parameters in the equation of the human oyygen saturation curve [16] were fitted for the pig's oxygen saturation curve, based on pig blood data from other experiments in our laboratory. This oxygen saturation curve was similar to the curve described by Bartels and Harms [17].…”

Section: Surgerymentioning

confidence: 99%

Alternating versus synchronous ventilation of left and right lungs in piglets

1995

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Objective." We tested whether alternating ventilation (AV) of each lung (i. e. with a phase difference of half a ventilatory cycle) would decrease central venous pressure and so increase cardiac output when compared with simultaneous ventilation (SV) of both lungs.Theory: If, during AV, the inflated lung expands partly via compression of the opposite lung, mean lung volume will be smaller during AV than SV. As a consequence, mean intrathoracic pressure (as cited in the literature), and therefore, central venous pressure will be smaller. Design:The experiments were performed in seven anaesthetized and paralyzed piglets using a doublepiston ventilator. Minute ventilation was the same during AV and SV. Starting at SV, we alternated three times between AV and SV for periods of 10 min.Results: During AV, central venous pressure was decreased by 0.7 mmHg and cardiac output was increased by 10+4.4~ (mean, + SD) compared with SV. AV also resulted in increased arterial pressure. During one-sided inflation with closed outlet of the opposite lung, a pressure rise occurred in the opposite lung, indicating compression. Conclusion:The higher cardiac output during AV than SV can be explained by the fact that central venous pressure is lower during AV. This lower central venous pressure is very probably due to the lower mean intrathoracic pressure caused by compression of the opposite lung during unilateral inflation.

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Oxygen

Karbing¹,

Rees²

2020

Cotes’ Lung Function

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Digital computer subroutine for the conversion of oxygen tension into saturation.

Cited by 484 publications

References 0 publications

The in-vivo oxyhaemoglobin dissociation curve at sea level and high altitude

The in-vivo oxyhaemoglobin dissociation curve at sea level and high altitude

Alternating versus synchronous ventilation of left and right lungs in piglets

Oxygen

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