“…These included the rule-based and hypothesis-list approaches used in the DENDRAL Project [9,10], which influenced MYCIN, as well as experimental, instructional, interview-based, and cognitive approaches to the analysis of clinical problem solving [11,12,13,14,15,16], and the causal-taxonomic representation of underlying processes of disease [4,11]. While earlier computer models for medical decision-making were predominantly statistical or algorithmic [16,17,18,19,20,21,22,23,24], the new AI approaches developed structured representations of specific clinical domain knowledge over which a general inference engine could reason with a variety of heuristics, and provide advice or suggestions to the consulting user [25].…”