Digital Breast Tomosynthesis Is Comparable to Mammographic Spot Views for Mass Characterization

Noroozian, Mitra; Hadjiiski, Lubomir M.; Rahnama‐Moghadam, Sahand; Klein, Katherine A.; Jeffries, Deborah O.; Pinsky, Renee W.; Chan, Heang Ping; Carson, Paul L.; Helvie, Mark A.; Roubidoux, Marilyn A.

doi:10.1148/radiol.11101763

Cited by 142 publications

(97 citation statements)

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“…Although this study was not designed to assess DBT in the diagnostic and assessment setting, improved visualisation of benign and malignant features using DBT could reduce the need for additional ultrasound, MRI or supplemental mammographic imaging. [39][40][41][42] The screening population would also benefit if some of the anxiety and stress associated with breast screening from unnecessary recalls and additional testing could be reduced.…”

Section: Resultsmentioning

confidence: 99%

“…[28][29][30] Improved lesion visibility, size and classification compared with standard film or digital mammography have been reported [31][32][33][34][35][36][37][38] and the possibility that DBT could reduce the need for additional mammographic views at least for non-calcified lesions [39][40][41][42] has been suggested. There are mixed reports of the sensitivity of DBT for the detection of microcalcifications 32,[43][44][45][46][47][48][49][50][51] that may be partly as a result of the different techniques used for image reconstruction and the need to combine image slices into thicker slabs for optimal visualisation of microcalcification clusters.…”

Section: Diagnostic Accuracymentioning

confidence: 99%

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The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme – a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone

Gilbert

Tucker

Gillan

et al. 2015

Health Technology Assessment

154

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The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme -a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: http://www.nets.nihr.ac.uk/programmes/hta This reportThe research reported in this issue of the journal was funded by the HTA programme as project number 09/22/182. The contractual start date was in December 2010. The draft report began editorial review in February 2014 and was accepted for publication in August 2014. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the draft document. However, they do not accept liability for damages or losses arising from material published in this report. Background: Digital breast tomosynthesis (DBT) is a three-dimensional mammography technique with the potential to improve accuracy by improving differentiation between malignant and non-malignant lesions.

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Section: Resultsmentioning

confidence: 99%

Section: Diagnostic Accuracymentioning

confidence: 99%

The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme – a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone

Gilbert

Tucker

Gillan

et al. 2015

Health Technology Assessment

154

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“…In a study of 67 masses in 67 women, DBT had similar performance to that of mammography spot views (120). In a study of 217 noncalcified lesions in 182 patients that included asymmetries and architectural distortion in addition to masses, the average AUC was higher with DBT than with mammography supplemental views (121).…”

Section: Retrospective Multireader Multicase Studiesmentioning

confidence: 96%

Digital Breast Tomosynthesis: State of the Art

et al. 2015

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This topical review on digital breast tomosynthesis (DBT) is provided with the intent of describing the state of the art in terms of technology, results from recent clinical studies, advanced applications, and ongoing efforts to develop multimodality imaging systems that include DBT. Particular emphasis is placed on clinical studies. The observations of increase in cancer detection rates, particularly for invasive cancers, and the reduction in false-positive rates with DBT in prospective trials indicate its benefit for breast cancer screening. Retrospective multireader multicase studies show either noninferiority or superiority of DBT compared with mammography. Methods to curtail radiation dose are of importance

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“…Even more important, tomosynthesis may reduce the rate of false-positive breast biopsies. Several studies have shown that tomosynthesis is subjectively preferred to conventional mammography, and it may offer superior diagnostic accuracy for the evaluation of breast lesions (5)(6)(7)(8)(9)(10)(11)(12).…”

mentioning

confidence: 99%

Digital Breast Tomosynthesis versus Supplemental Diagnostic Mammographic Views for Evaluation of Noncalcified Breast Lesions

Zuley¹,

Bandos²,

Ganott³

et al. 2013

Radiology

169

101

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Purpose:To compare the diagnostic performance of breast tomosynthesis versus supplemental mammography views in classification of masses, distortions, and asymmetries. Materials and Methods:Eight radiologists who specialized in breast imaging retrospectively reviewed 217 consecutively accrued lesions by using protocols that were HIPAA compliant and institutional review board approved in 182 patients aged 31-60 years (mean, 50 years) who underwent diagnostic mammography and tomosynthesis. The lesions in the cohort included 33% (72 of 217) cancers and 67% (145 of 217) benign lesions. Eighty-four percent (182 of 217) of the lesions were masses, 11% (25 of 217) were asymmetries, and 5% (10 of 217) were distortions that were initially detected at clinical examination in 8% (17 of 217), at mammography in 80% (173 of 217), at ultrasonography (US) in 11% (25 of 217), or at magnetic resonance imaging in 1% (2 of 217). Histopathologic examination established truth in 191 lesions, US revealed a cyst in 12 lesions, and 14 lesions had a normal follow-up. Each lesion was interpreted once with tomosynthesis and once with supplemental mammographic views; both modes included the mediolateral oblique and craniocaudal views in a fully crossed and balanced design by using a five-category Breast Imaging Reporting and Data System (BI-RADS) assessment and a probability-of-malignancy score. Differences between modes were analyzed with a generalized linear mixed model for BI-RADS-based sensitivity and specificity and with modified Obuchowski-Rockette approach for probability-of-malignancy-based area under the receiver operating characteristic (ROC) curve. Results:Average probability-of-malignancy-based area under the ROC curve was 0.87 for tomosynthesis versus 0.83 for supplemental views (P , .001). With tomosynthesis, the false-positive rate decreased from 85% (989 of 1160) to 74% (864 of 1160) (P , .01) for cases that were rated BI-RADS category 3 or higher and from 57% (663 of 1160) to 48% (559 of 1160) for cases rated BI-RADS category 4 or 5 (P , .01), without a meaningful change in sensitivity.With tomosynthesis, more cancers were classified as BI-RADS category 5 (39% [226 of 576] vs 33% [188 of 576]; P = .017) without a decrease in specificity. Conclusion:Tomosynthesis significantly improved diagnostic accuracy for noncalcified lesions compared with supplemental mammographic views.

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Digital Breast Tomosynthesis Is Comparable to Mammographic Spot Views for Mass Characterization

Abstract: In this small study, mass characterization in terms of visibility ratings, reader performance, and BI-RADS assessment with DBT was similar to that with MSVs. Preliminary findings suggest that MSV might not be necessary for mass characterization when performing DBT.

Cited by 142 publications

References 25 publications

The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme – a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone

The TOMMY trial: a comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme – a multicentre retrospective reading study comparing the diagnostic performance of digital breast tomosynthesis and digital mammography with digital mammography alone

Digital Breast Tomosynthesis: State of the Art

Digital Breast Tomosynthesis versus Supplemental Diagnostic Mammographic Views for Evaluation of Noncalcified Breast Lesions

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