Digital breast tomosynthesis image reconstruction using 2D and 3D total variation minimization

Ertaş, Metin; Yıldırım, İsa; Kamasak, Mustafa E.; Akan, Aydın

doi:10.1186/1475-925x-12-112

Cited by 42 publications

(24 citation statements)

References 24 publications

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“…In addition, total variation (TV) [23–25] which is an effective sparsifying transform for medical images, was also applied. TV minimizing significantly preserves edges and creates a smoother image.…”

Section: Methodsmentioning

confidence: 99%

Geometry calibration between X-ray source and detector for tomosynthesis with a portable X-ray system

et al. 2017

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PurposeTomosynthesis is attracting attention as a low-dose tomography technology compared with X-ray CT. However, conventional tomosynthesis imaging devices are large and stationary. Furthermore, there is a limitation in the working range of the X-ray source during image acquisition. We have previously proposed the use of a portable X-ray device for tomosynthesis that can be used for ward rounds and emergency medicine. The weight of this device can be reduced by using a flat panel detector (FPD), and flexibility is realized by the free placement of the X-ray source and FPD. Tomosynthesis using a portable X-ray device requires calibration of the geometry between the X-ray source and detector at each image acquisition. We propose a method for geometry calibration and demonstrate tomosynthesis image reconstruction by this method.MethodsAn image processing-based calibration method using an asymmetric and multilayered calibration object (AMCO) is presented. Since the AMCO is always attached to the X-ray source housing for geometry calibration, the additional setting of a calibration object or marker around or on the patients is not required. The AMCO’s multilayer structure improves the calibration accuracy, especially in the out-of-plane direction.ResultsTwo experiments were conducted. The first was performed to evaluate the calibration accuracy using an XY positioning stage and a gonio stage. As a result, an accuracy of approximately 1 mm was achieved both in the in-plane and out-of-plane directions. An angular accuracy of approximately was confirmed. The second experiment was conducted to evaluate the reconstructed image using a foot model phantom. Only the sagittal plane could be clearly observed with the proposed method.ConclusionWe proposed a tomosynthesis imaging system using a portable X-ray device. From the experimental results, the proposed method could provide sufficient calibration accuracy and a clear sagittal plane of the reconstructed tomosynthesis image.

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Section: Methodsmentioning

confidence: 99%

Geometry calibration between X-ray source and detector for tomosynthesis with a portable X-ray system

et al. 2017

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“…In particular the structure similarity index (SSIM) [15,16] was used to measure the fidelity of the distortion. Since the distortion only affects the structure of the objects in the scene and not the brightness, the SSIM resulted as a good choice to explore the structural information in the images separating it from the influence of the luminosity of the light source (projector).…”

Section: Methodsmentioning

confidence: 99%

A new method to measure higher visual functions in an immersive environment

et al. 2014

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BackgroundHigher visual functions can be defined as cognitive processes responsible for object recognition, color and shape perception, and motion detection. People with impaired higher visual functions after unilateral brain lesion are often tested with paper pencil tests, but such tests do not assess the degree of interaction between the healthy brain hemisphere and the impaired one. Hence, visual functions are not tested separately in the contralesional and ipsilesional visual hemifields.MethodsA new measurement setup, that involves real-time comparisons of shape and size of objects, orientation of lines, speed and direction of moving patterns, in the right or left visual hemifield, has been developed. The setup was implemented in an immersive environment like a hemisphere to take into account the effects of peripheral and central vision, and eventual visual field losses. Due to the non-flat screen of the hemisphere, a distortion algorithm was needed to adapt the projected images to the surface. Several approaches were studied and, based on a comparison between projected images and original ones, the best one was used for the implementation of the test. Fifty-seven healthy volunteers were then tested in a pilot study. A Satisfaction Questionnaire was used to assess the usability of the new measurement setup.ResultsThe results of the distortion algorithm showed a structural similarity between the warped images and the original ones higher than 97%. The results of the pilot study showed an accuracy in comparing images in the two visual hemifields of 0.18 visual degrees and 0.19 visual degrees for size and shape discrimination, respectively, 2.56° for line orientation, 0.33 visual degrees/s for speed perception and 7.41° for recognition of motion direction. The outcome of the Satisfaction Questionnaire showed a high acceptance of the battery by the participants.ConclusionsA new method to measure higher visual functions in an immersive environment was presented. The study focused on the usability of the developed battery rather than the performance at the visual tasks. A battery of five subtasks to study the perception of size, shape, orientation, speed and motion direction was developed. The test setup is now ready to be tested in neurological patients.

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“…The 3D Total Variation regularization (3D-TV) [23] is also implemented for 3D image reconstruction as comparison, which is formulated as…”

Section: B 3d Total Variation Regularizationmentioning

confidence: 99%

“…The structure, manufacture and modelling of the sensor are demonstrated and its sensitivity is analyzed. A novel 3D-Laplacian and sparsity joint regularization algorithm is proposed for enhanced 3D imaging, while the results are compared with 3D Total Variation (3D-TV) regularization method [23]. To evaluate the performance of the planar miniature EIT sensor and the proposed 3D image reconstruction algorithm, both simulations of test phantoms and experiments of breast cancer cell are conducted.…”

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confidence: 99%

A Miniature Electrical Impedance Tomography Sensor and 3-D Image Reconstruction for Cell Imaging

et al. 2017

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Real-time quantitative imaging is becoming highly desirable to study nondestructively the biological behavior of three dimensional cell culture systems. In this work, we investigate the feasibility of quantitative imaging/monitoring of 3D cell culture processes via Electrical Impedance Tomography (EIT), which is capable of generating conductivity images in a non-destructive manner with high temporal resolution. To this end, a planar miniature EIT sensor amenable to standard cell culture format is designed and a 3D forward model for the sensor is developed for 3D imaging. Furthermore, a novel 3D-Laplacian and sparsity joint regularization algorithm is proposed for enhanced 3D image reconstruction. Simulation phantoms with spheres at various vertical and horizontal positions were imaged for 3D performance evaluation. In addition, experiments on human breast cancer cell spheroid and a triangular breast cancer cell pellet were carried out for experimental verification. The results have shown that stable measurement on high conductive cell culture medium and significant improvement of image quality based on the proposed regularization method are achieved. It demonstrates the feasibility of using the miniature EIT sensor and 3D image reconstruction algorithm to visualize 3D cell cultures such as spheroids or artificial tissues and organs. The established work would expedite real-time quantitative imaging of 3D cell culture for assessment of cellular dynamics.

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Digital breast tomosynthesis image reconstruction using 2D and 3D total variation minimization

Cited by 42 publications

References 24 publications

Geometry calibration between X-ray source and detector for tomosynthesis with a portable X-ray system

Geometry calibration between X-ray source and detector for tomosynthesis with a portable X-ray system

A new method to measure higher visual functions in an immersive environment

A Miniature Electrical Impedance Tomography Sensor and 3-D Image Reconstruction for Cell Imaging

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