Digestive System, Liver, and Abdominal Cavity

Baral, Randolph M.

doi:10.1016/b978-1-4377-0660-4.00023-5

Cited by 2 publications

(1 citation statement)

References 442 publications

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“…Famotidine is a competitive inhibitor of the histamine (H2) receptor, the dominant receptor involved in gastric acid secretion that abolishes the activation of adenylate cyclase induced by histamines. Famotidine is able to effectively suppress meal-stimulated acid secretion with higher efficiency than Ranitidine [29][30][31]. Olanzapine is an atypical antipsychotic agent used for treatment of schizophrenia.…”

Section: Kinase Inhibitory Properties Of Investigated Drugsmentioning

confidence: 99%

Drug Repurposing in Dentistry: Towards Application of Small Molecules in Dentin Repair

Birjandi

Suzano

Sharpe

2020

IJMS

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One of the main goals of dentistry is the natural preservation of the tooth structure following damage. This is particularly implicated in deep dental cavities affecting dentin and pulp, where odontoblast survival is jeopardized. This activates pulp stem cells and differentiation of new odontoblast-like cells, accompanied by increased Wnt signaling. Our group has shown that delivery of small molecule inhibitors of GSK3 stimulates Wnt/β-catenin signaling in the tooth cavity with pulp exposure and results in effective promotion of dentin repair. Small molecules are a good therapeutic option due to their ability to pass across cell membranes and reach target. Here, we investigate a range of non-GSK3 target small molecules that are currently used for treatment of various medical conditions based on other kinase inhibitory properties. We analyzed the ability of these drugs to stimulate Wnt signaling activity by off-target inhibition of GSK3. Our results show that a c-Met inhibitor, has the ability to stimulate Wnt/β-catenin pathway in dental pulp cells in vitro at low concentrations. This work is an example of drug repurposing for dentistry and suggests a candidate drug to be tested in vivo for natural dentin repair. This approach bypasses the high level of economical and time investment that are usually required in novel drug discoveries.

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Section: Kinase Inhibitory Properties Of Investigated Drugsmentioning

confidence: 99%

Drug Repurposing in Dentistry: Towards Application of Small Molecules in Dentin Repair

Birjandi

Suzano

Sharpe

2020

IJMS

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Surgical intervention for the correction of fecal impaction in an obstipated cat with an old compression injury in the lumbosacral region of the spine

Munif,

Safawat,

Hannan

2023

Bull Natl Res Cent

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Background Feline obstipation is a clinical condition often manifested by defecation inability that results in fecal impaction. This is frequently associated with a blunt traumatic injury that affects mostly the spine and surrounding structures in the caudal part of the back leading to vertebral compression. Case presentation A 6-month-old, female, mixed-breed cat of 1.49-kg BW was presented with a history of prolonged constipation (i.e., obstipation) along with discomfort and weakness. Prior to the presentation, the cat was medically treated with dietary fibers, fecal softeners, and enemas, but obstipation persisted. Clinical examinations revealed that there was straining but not effective for defecation. In addition, the cat had poor appetite and dehydration, electrolyte abnormalities, and defects in posture and gait. The lumbosacral region showed a depression that was supposed to be the consequence of an old, untreated regional injury. Radiographic imaging indicated a marked ventral curvature in the lumbosacral spine including major deviations in the positions of the L6 and L7 vertebrae and the sacrum as well. A firm tubular structure was felt on ventral abdominal palpation, and further ultrasonography revealed the tubular impaction. Laparotomy exposed a definite large bowel impaction, and enterotomy was performed to evacuate the firm feces. Postoperatively, supportive medications and care were provided for better recovery. However, the impaction recurred within 3 months after surgery, and euthanasia was a further choice. Conclusions Traumatic injuries involving the lumbosacral spine in cats might be serious enough to lead to severe constipation and thereby bowel impaction. Therefore, treatment should be prompt and accurate in any case of spinal injury to avoid further complications.

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Digestive System, Liver, and Abdominal Cavity

Cited by 2 publications

References 442 publications

Drug Repurposing in Dentistry: Towards Application of Small Molecules in Dentin Repair

Drug Repurposing in Dentistry: Towards Application of Small Molecules in Dentin Repair

Surgical intervention for the correction of fecal impaction in an obstipated cat with an old compression injury in the lumbosacral region of the spine

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