Digestive properties and effects of Chimonanthus nitens Oliv polysaccharides on antioxidant effects in vitro and in immunocompromised mice

Zhang, Yang; Han, Yi; He, Jing; Ouyang, Kehui; Zhao, Meng; Cai, Lei; Zhao, Zitong; Meng, Wenya; Chen, Lingli; Wang, Wenjun

doi:10.1016/j.ijbiomac.2021.06.114

Cited by 23 publications

(18 citation statements)

References 53 publications

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“…44 Zhang et al reported that the polysaccharides from Chimonanthus nitens Oliv could decrease oxidation stress and protect the liver in Cy-induced immunocompromised mice by reducing the upstream factor Keap1 and elevating the upstream factor Nrf2, which eventually reinforced the expression of the downstream factors (NQO1, HO-1, GSH-Px, SOD1, and CAT). 45 Moreover, Li et al reported that Ostrea rivularis polysaccharides could effectively attenuate the reproductive oxidative stress injury derived from Cy via activating the Keap1-Nrf2/ARE signaling pathway. 46 Consistent with these findings, we found that EPS103 remarkably regulated the expression of Nrf2 protein upward and regulated the expressing of Keap1 protein downward in the small intestine.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Effects of Exopolysaccharides from Lactiplantibacillus plantarum JLAU103 on Intestinal Immune Response, Oxidative Stress, and Microbial Communities in Cyclophosphamide-Induced Immunosuppressed Mice

Gao

et al. 2022

J. Agric. Food Chem.

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This study investigated the effects of the exopolysaccharide from Lactiplantibacillus plantarum JLAU103 (EPS103) on the intestinal immune response, oxidative stress, intestinal mucosal barrier, and microbial community in cyclophosphamide-induced immune-suppressed mice. The results showed that EPS103 promoted the secretion of cytokines and the generation of secretory immunoglobulin A and mucin-2 in the small intestine of mice, which might be related to the activation of the MAPK pathway. Additionally, EPS103 protected against oxidative stress by activating antioxidation enzymes and Nrf2/Keap1 pathways. It also improved the intestinal physical barrier functions via regulating the ratio of villous height to crypt depth and upregulating the expression of tight-junction proteins. Meanwhile, EPS103 promoted the generation of short-chain fatty acids (SCFAs) and modulated the constituents of gut microbiota. These results suggested that EPS103 may modulate the intestinal immunoresponse relying on the regulation of SCFA production and gut microbiota in immunosuppressed mice, resulting in the activation of systemic immunity.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Effects of Exopolysaccharides from Lactiplantibacillus plantarum JLAU103 on Intestinal Immune Response, Oxidative Stress, and Microbial Communities in Cyclophosphamide-Induced Immunosuppressed Mice

Gao

et al. 2022

J. Agric. Food Chem.

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“…GSH-Px, a vital part of peroxidase, can protect the structure and function of the cell membrane from the interference and damage of peroxides in the body ( 59 ). In previous research studies, it had been figured out that Chimonanthus nitens Oliv polysaccharides and Gynostemma pentaphyllum polysaccharides protected immunosuppressed mice by relieving oxidative damage ( 60 , 61 ). The activities of GSH-PX and T-SOD in the liver of mice in the ACP group increased, suggesting that ACP has an obvious antagonistic effect on the decrease of antioxidant capacity induced by CTX.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effects of Three Polysaccharides From Abrus cantoniensis Against Cyclophosphamide-Induced Immunosuppression and Oxidative Damage

Lian

et al. 2022

Front. Vet. Sci.

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This study was designed to systematically elucidate the immunomodulatory and antioxidant effects of three polysaccharide fractions (ACP60, ACP80, and ACPt2) from Abrus cantoniensis on cyclophosphamide (CTX)-induced immunosuppressive mice. The experimental mice were divided into 12 groups, then modeled and administrated with different doses of three polysaccharides (50, 150, 300 mg/kg/day) by gavage. The results showed that ACP could markedly recover the CTX-induced decline in immune organ and hemocytes indexes and promote proliferation of splenocytes, earlap swelling rate, secretion of cytokines (TNF-α, IFN-γ, IL-1β, IL-6), and immunoglobulin (Ig-M and Ig-G). Additionally, ACP improved the enzymatic activities of T-SOD and GSH-PX greatly, while the level of MDA was significantly decreased in the liver. In particular, ACPt2 had higher immunomodulatory and antioxidant activities than ACP60 and ACP80. Based on the present findings, ACP could be utilized as an efficacious candidate for immunomodulators and antioxidants, which provide a new application prospect in the food and pharmaceutical industries.

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“…As the antioxidant system is damaged, excessive lipid peroxides MDA is produced and leads to cell damage [ 51 ]. SOD and GSH-Px are the main enzymes of scavenging free radicals, and they are involved in scavenging superoxide and intermediate products produced in the oxidation process [ 24 ]. In our study, we found that TFC can regulate the balance of free radicals by increasing the activity of antioxidant enzymes and inhibiting lipid peroxidation and improved HFD-induced oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…Its leaves are consumed as a traditional Chinese tea, which is also called Golden tea or Shi-Liang tea. In previous studies, we have demonstrated that CNO can enhance antioxidant capacity, regulate glucolipid metabolism, possess antibacterial properties, and modulate the immune system [ 23 , 24 , 25 ]. However, there are few reports about the ameliorative effect of CNO leaves on NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Total Flavonoids from Chimonanthus nitens Oliv. Leaves Ameliorate HFD-Induced NAFLD by Regulating the Gut–Liver Axis in Mice

Meng

Zhao

Chen

et al. 2022

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Non-alcoholic fatty liver disease (NAFLD) is one of the chronic liver diseases with high incidence in the world. This study aimed to investigate whether total flavonoids from Chimonanthus nitens Oliv. leaves (TFC) can ameliorate NAFLD. Herein, a high-fat diet (HFD)-induced NAFLD mice model was established, and TFC was administered orally. The results showed that TFC reduced the body weight and liver index and decreased the serum and hepatic levels of triglyceride (TG) and total cholesterol (TC). TFC significantly reduced the activity of liver functional transaminase. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) decreased by 34.61% and 39.57% in serum and 22.46% and 40.86% in the liver, respectively. TFC regulated the activities of oxidative-stress-related enzymes and upregulated the protein expression of nuclear factor E2-related factor (Nrf2)/heme oxygenase (HO-1) pathway in NAFLD mice, and the activities of total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-PX) in serum were increased by 89.76% and 141.77%, respectively. In addition, TFC reduced the levels of free fatty acids (FFA), endotoxin (ET), and related inflammatory factors in mouse liver tissue and downregulated the expression of proteins associated with inflammatory pathways. After TFC treatment, the levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-1β in the liver tissues of NAFLD mice were downregulated by 67.10%, 66.56%, and 61.45%, respectively. Finally, TFC reduced liver fat deposition, oxidative stress, and inflammatory response to repair liver damage and alleviate NAFLD. Further studies showed that TFC regulated the expression of intestinal-barrier-related genes and improved the composition of gut microbiota. Therefore, TFC reduced liver inflammation and restored intestinal homeostasis by regulating the gut–liver axis. Overall, our findings revealed a novel function of TFC as a promising prophylactic for the treatment of NAFLD.

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Digestive properties and effects of Chimonanthus nitens Oliv polysaccharides on antioxidant effects in vitro and in immunocompromised mice

Cited by 23 publications

References 53 publications

Effects of Exopolysaccharides from Lactiplantibacillus plantarum JLAU103 on Intestinal Immune Response, Oxidative Stress, and Microbial Communities in Cyclophosphamide-Induced Immunosuppressed Mice

Effects of Exopolysaccharides from Lactiplantibacillus plantarum JLAU103 on Intestinal Immune Response, Oxidative Stress, and Microbial Communities in Cyclophosphamide-Induced Immunosuppressed Mice

The Protective Effects of Three Polysaccharides From Abrus cantoniensis Against Cyclophosphamide-Induced Immunosuppression and Oxidative Damage

Total Flavonoids from Chimonanthus nitens Oliv. Leaves Ameliorate HFD-Induced NAFLD by Regulating the Gut–Liver Axis in Mice

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