Digestive promoting effect and mechanism of Jiao Sanxian in rats

Liu, Ying; Liao, Wenting; Liu, Xingran; Hu, Yunwei; Zhu, Xiaoxia; Ju, Longtao; Feng, Feng; Qu, Wei; Liu, Wenyuan; Xu, Jian

doi:10.1016/j.jep.2021.114334

Cited by 19 publications

(7 citation statements)

References 67 publications

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“…The traditional theory of Chinese medicine holds that "fried to brown" helps to improve digestive function and promote gastrointestinal motility. Many herbal medicines that are fried to brown are thought to promote digestion (Liu et al, 2021). Hawthorn has a long history of being used to treat indigestion, and it often appears in prescriptions related to digestive function.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the improving effect of raw and charred hawthorn on functional dyspepsia based on interstitial cells of Cajal

Zhang²,

Liang³

et al. 2022

Front. Sustain. Food Syst.

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BackgroundRaw hawthorn (RH) is a traditional Chinese medicine commonly used to treat indigestion. Charred hawthorn (CH) is obtained from RH by charring. It is reported that the effect of CH treatment on dyspepsia is stronger than RH. However, this has not been fully proven. The purpose of this study was to compare the effects of RH and CH on functional dyspepsia (FD) model rats. And contribute to the development of dietary therapy for dyspepsia.MethodsSPF-grade male SD rats were divided into 5 groups: the control group, the model group, the Mos group, the RH group, and the CH group. The FD rat model was established by using the methods of water restriction, fasting, tilting cage restraint, day and night upside down, swimming, and tail damping. The body weight of rats in each group was recorded. And the gastric emptying rate, intestinal propulsive rate, and the levels of motilin (MTL), gastrin (GAS), and 5-HT in serum were compared in each group. The expression of C-kit in the stomach and small intestine of each group was compared by immunofluorescence and PCR.ResultsRH and CH could increase weight, improve the gastric emptying rate and intestinal propulsive rate, and promote the secretion of motilin (MTL), gastrin (GAS), and 5-HT in the serum of FD rats. RH and CH can upregulate the expression of the characteristic protein c-kit of ICC in the stomach and small intestine of FD model rats, and the effect of CH is stronger than RH.ConclusionRH and CH may increase the number of interstitial cells of Cajal (ICC) in the gastrointestinal tract by upregulating c-kit expression, thus improving gastrointestinal motility in FD model rats. And compared with RH, CH has certain advantages.

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Section: Discussionmentioning

confidence: 99%

Investigation of the improving effect of raw and charred hawthorn on functional dyspepsia based on interstitial cells of Cajal

Zhang²,

Liang³

et al. 2022

Front. Sustain. Food Syst.

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“…For these reasons, "Jiao Sanxian" is a widely used medicine for enhancing digestion and improving stagnation in China. Recently, a basic study reported that "Jiao Sanxian" can improve functional dyspepsia in rats and the mechanism involves regulating the secretion of brain-gut peptides, improving the disorder of intestinal flora and ameliorating multi-metabolic pathways (Liu et al, 2021). Other main components, such as Hawthorn, Atractylodis Rhizoma, Codonopsis, Amomi Fructus, and Rhizoma Corydalis, have been used as traditional medicines and/or food materials, which have extensive pharmacological activities in gastrointestinal function regulation and almost no toxicity.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Shenqu Xiaoshi Oral Liquid Compared With Domperidone Syrup in Children With Functional Dyspepsia

Xie

et al. 2022

Front. Pharmacol.

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Background: Treatment of functional dyspepsia (FD) in children is generally symptomatic and unsatisfactory. Traditional Chinese medicines, such as Shenqu Xiaoshi Oral Liquid (SXOL), have been recommended to alleviate dyspeptic symptoms. However, evidence of their safety and efficacy remains limited to date. AIM: To assess whether 2 weeks of therapy with SXOL was non-inferior to domperidone syrup in children with FD.Methods: In this randomized, double-blind, double-simulated, non-inferiority, multi-center clinical trial, we recruited children (3–14 years) with FD according to the Rome IV criteria from 17 tertiary medical centers across China. Patients were randomly allocated (1:1) to receive SXOL or domperidone syrup for 2 weeks. We compared the participants’ clinical scores from both groups based on the severity and frequency of dyspepsia symptoms according to Rome IV criteria (0, 1, 2, and 4 weeks after randomization). The primary endpoint was the total response rate, which was defined as the proportion of patients with a decrease of 30% or more in the FD symptoms clinical score from baseline, at the end of the 2-weeks treatment. A non-inferiority margin of -10% was set. Secondary endpoints and adverse events were assessed. This trial is registered with www.Chictr.org.cn, number ChiCTR1900022654.Results: Between February 2019 and March 2021, a total of 373 patients were assessed for eligibility, and 356 patients were enrolled and randomized. The clinical response rate at week two was similar for SXOL [118 (83.10%) of 142] and domperidone [128 (81.01%) of 158]; difference 2.09; 95% CI −6.74 to 10.71, thereby establishing non-inferiority. The total FD symptom scores were significantly improved in the two groups at 1-, 2-, and 4-weeks follow-up periods (p < 0.005). The decrease in symptom score compared with the baseline were similar between these two groups. Over the total study period, 10 patients experienced at least one treatment-related adverse event [six (3.37%)] in the SXOL group, four [(2.25%) in the domperidone group], although no serious adverse event was noted.Conclusion: Treatment with SXOL effectively improves dyspeptic symptoms and is well tolerated. In addition, it is not inferior to domperidone syrup and leads to sustained improvement in Chinese children with FD.

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“…When a high-protein, high-calorie, high-fat diet was used to induce dyspepsia in mice, the intestinal microbiota was dramatically disturbed, and the abundance of the Genus Lachnospiraceae NK4A 136 group was signi cantly elevated [36] . Additionally, the Jiao Sanxian decoction (JSXD) group demonstrated an effect of somewhat mitigating the scenario whereby the rats in the model group were highly enriched in Genus Lachnospiraceae NK4A 136 group as compared to the control group [37] .…”

Section: Discussionmentioning

confidence: 99%

The causality between gut microbiota and functional dyspepsia: a two-sample Mendelian randomization analysis

Jin,

Xu,

et al. 2024

Preprint

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Introduction:To investigate the potential link between gut microbiota and functional dyspepsia (FD). Methods: Genome-wide association studies (GWAS) of gut microbiota and FD were used in Mendelian randomization (MR) research. Using the GWAS of 18,340 people, instrumental variables related to gut microbiota as an exposure factor were identified. In a GWAS investigation, 189695 control individuals and 4376 FD patients from Europe were included as outcome variables. The primary analysis technique was inverse variance weighted analysis (IVW). The reliability of MR Analysis results is tested using sensitivity analysis. Results: TSMR analysis revealed the presence of seven gut microbiota associated to FD. In the IVW method, Order Erysipelotrichales (odds ratio (OR): 1.301; 95% confidence interval (CI): 1.016,1.665;P=0.037),Family Erysipelotrichales (OR:1.301;95%CI:1.016,1.665;P=0.037), Genus Haemophilus (OR:1.236;95%CI 1.059, 1.442;P=0.007), Genus Ruminiclostridium9 (OR:1.422; 95%CI:1.078, 1.877; P=0.013),Genus Lachnospiraceae NK4A 136 group (OR:1.297;95%CI:1.059, 1.589; P=0.012) was positively associated with functional dyspepsia. Class Gammaproteobacteria (OR:0.705;95%CI:0.522,0.952;P=0.022) and Genus Erysipelatoclostridium (OR:0.747;95%CI:0.628,0.888;P=0.001) were found to be inversely related to functional dyspepsia. There was no evidence of pleiotropy or heterogeneity in the sensitivity analysis. Conclusions:Our research provides evidence for a possible link between FD and a number of gut microbiota. The role that gut microbiota plays in the development of FD requires more investigation.

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Digestive promoting effect and mechanism of Jiao Sanxian in rats

Cited by 19 publications

References 67 publications

Investigation of the improving effect of raw and charred hawthorn on functional dyspepsia based on interstitial cells of Cajal

Investigation of the improving effect of raw and charred hawthorn on functional dyspepsia based on interstitial cells of Cajal

Efficacy and Safety of Shenqu Xiaoshi Oral Liquid Compared With Domperidone Syrup in Children With Functional Dyspepsia

The causality between gut microbiota and functional dyspepsia: a two-sample Mendelian randomization analysis

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