Every day, millions of tons of plastic waste are produced by humans which causes severe impacts on our ecosystem and biodiversity. Nowadays plastic is the main anthropogenic waste material globally due to irrational production, inappropriate and unscientific disposal, and inadequate recycling management of plastic. As a result, the fauna of the terrestrial and aquatic ecosystems both are in danger of plastic pollution. Birds are an important part of our biodiversity and they are affected by plastic pollution. Nowadays, birds use plastic debris for different purposes which ultimately causes the death of birds. Plastic waste occupies the global landscape and has parallel impacts on different species of insects. Bees have started to use plastics as brood material. Marine and land mammals both are severely affected by plastic pollution. Plastic pollution is an emergency danger for coral reefs and all food webs do exist at coral reefs. Every day many fish lose their life by suffocation from entering plastic bags and eating or entangling plastic debris. Plastic pollution has many harmful effects on amphibians and reptiles such as habitat disruption, disease transmission, reproductive and physical health problems, etc. In this book chapter, we have discussed the effect of plastic pollution on different types of faunal survival as well as diversity and also probable sustainable solutions to save our mother earth and its fauna from plastic pollution.