Digestion stability and evaluation of the metabolism and transport of olive oil phenols in the human small-intestinal epithelial Caco-2/TC7 cell line

Soler, Aranzazu; Bolaño-Romero, María Paz; Macià, Alba; Saha, Shikha; Furniss, Caroline S.M.; Kroon, Paul A.; Motilva, Marı́a-José

doi:10.1016/j.foodchem.2009.07.017

Cited by 79 publications

(107 citation statements)

References 28 publications

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“…The metabolism of olive oil lignans has not been reported in detail so far and one of the few references appeared only recently (Soler et al, 2010). In this study, pinoresinol glucuronide and sulfate conjugates were identified after incubation of free pinoresinol using differentiated Caco-2/TC7 cell monolayers.…”

Section: Conjugation and Nature Of Metabolitesmentioning

confidence: 83%

“…They also demonstrated that Hyty was transported across the membrane of the human enterocytes by a bidirectional passive diffusion mechanism. Caco-2/TC7 cell monolayers have been used to study the metabolism of other olive oil polyphenols, such as Ty, p-coumaric acid, pinoresinol, luteolin (Soler et al, 2010) and Hyty acetate (Mateos et al, 2011). Results showed that the methylated conjugates are the main metabolites and that the acetylation of Hyty significantly increases its transport across the small intestinal epithelial cell barrier, enhancing the delivery of Hyty to the enterocytes.…”

Section: Absorption and Dispositionmentioning

confidence: 99%

“…As far as flavonoids are concerned, products of methylation and glucuronidation have been observed (Soler et al, 2010;Suárez et al, 2009). Methyl-monoglucuronides of apigenin and luteolin have been identified as well (García-Villalba et al, 2010).…”

Section: Conjugation and Nature Of Metabolitesmentioning

confidence: 99%

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Metabolism and Bioavailability of Olive Oil Polyphenols

Gómez-Romero¹,

Garcı́a-Villalba²,

Carrasco‐Pancorbo³

et al. 2012

Olive Oil - Constituents, Quality, Health Properties and Bioconversions

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Section: Conjugation and Nature Of Metabolitesmentioning

confidence: 83%

Section: Absorption and Dispositionmentioning

confidence: 99%

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Metabolism and Bioavailability of Olive Oil Polyphenols

Gómez-Romero¹,

Garcı́a-Villalba²,

Carrasco‐Pancorbo³

et al. 2012

Olive Oil - Constituents, Quality, Health Properties and Bioconversions

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“…Using the Caco-2/TC7 cells as a model of the human intestinal epithelium, limited metabolism of olive oil phenolics was observed; the methylated conjugates were the major metabolites detected. 25 Extensive transport of the parent aglycones and their conjugates to the basolateral side was also shown. 25 A previous study on the uptake and metabolism of the phenolic compounds from an olive leaf extract in SKBR3 cells has shown important oleuropein and luteolin-7-O-b-D-glucoside uptake in the cytoplasm and further metabolism; luteolin aglycone was found among other metabolites.…”

Section: Discussionmentioning

confidence: 95%

Olive Leaf Extracts Are a Natural Source of Advanced Glycation End Product Inhibitors

Kontogianni

Charisiadis

Margianni

et al. 2013

Journal of Medicinal Food

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Advanced glycation end products (AGEs), which are readily formed and accumulated with sustained hyperglycemia, contribute to the development of diabetic complications. As a consequence, inhibition of AGE formation constitutes an attractive therapeutic/preventive target. In the current study, we explored the phytochemical composition and the in vitro effect of two different olive leaf extracts (an aqueous and a methanolic) on AGE formation. The methanolic olive leaf extract inhibited fluorescent AGE formation in a bovine serum albumin (BSA)-ribose system, whereas the aqueous extract had no effect in both BSA-fructose and BSA-ribose systems. The phytochemical profile was investigated with liquid chromatographyultraviolet-visible (UV-Vis) diode array coupled to electrospray ionization multistage mass spectrometry (LC/DAD/ESI-MS n ). Quantification of the major phenolic compounds was performed with high performance liquid chromatography with UV-Vis diode array detection and nuclear magnetic resonance spectroscopy. Among the major phenolic components (luteolin, hydroxytyrosol, luteolin-

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“…Chemical hydrolysis of secoiridoids can take place in the acidic medium of the stomach (20) or in alkaline conditions in the small intestine (21,22) leading to an increase of free phenolic alcohols released into the aqueous phase. As a result OO phenolic compounds are further absorbed in the small intestine (23) .…”

Section: Phenolic Compounds Bioavailability and Bioactivitymentioning

confidence: 99%

New perspectives on bioactivity of olive oil: evidence from animal models, human interventions and the use of urinary proteomic biomarkers

et al. 2015

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Olive oil (OO) is the primary source of fat in the Mediterranean diet and has been associated with longevity and a lower incidence of chronic diseases, particularly CHD. Cardioprotective effects of OO consumption have been widely related with improved lipoprotein profile, endothelial function and inflammation, linked to health claims of oleic acid and phenolic content of OO. With CVD being a leading cause of death worldwide, a review of the potential mechanisms underpinning the impact of OO in the prevention of disease is warranted. The current body of evidence relies on mechanistic studies involving animal and cell-based models, epidemiological studies of OO intake and risk factor, small-and large-scale human interventions, and the emerging use of novel biomarker techniques associated with disease risk. Although model systems are important for mechanistic research nutrition, methodologies and experimental designs with strong translational value are still lacking. The present review critically appraises the available evidence to date, with particular focus on emerging novel biomarkers for disease risk assessment. New perspectives on OO research are outlined, especially those with scope to clarify key mechanisms by which OO consumption exerts health benefits. The use of urinary proteomic biomarkers, as highly specific disease biomarkers, is highlighted towards a higher translational approach involving OO in nutritional recommendations.

show abstract

Digestion stability and evaluation of the metabolism and transport of olive oil phenols in the human small-intestinal epithelial Caco-2/TC7 cell line

Cited by 79 publications

References 28 publications

Metabolism and Bioavailability of Olive Oil Polyphenols

Metabolism and Bioavailability of Olive Oil Polyphenols

Olive Leaf Extracts Are a Natural Source of Advanced Glycation End Product Inhibitors

New perspectives on bioactivity of olive oil: evidence from animal models, human interventions and the use of urinary proteomic biomarkers

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