Digestion: Intestinal Secretion

Hendrix, Thomas R.; Bayless, T M

doi:10.1146/annurev.ph.32.030170.001035

Cited by 93 publications

(40 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our microscopic studies and those in the literature suggest they do (6,26). If in fact they do, our finding of marked sodium secretion in TGE is in keeping with the current hypothesis that crypt cells, unlike mature cells on villi are normally secretory (27). Obviously, may questions are raised by our data: many remain unanswered.…”

Section: Resultssupporting

confidence: 88%

Transmissible Gastroenteritis MECHANISMS RESPONSIBLE FOR DIARRHEA IN AN ACUTE VIRAL ENTERITIS IN PIGLETS

Butler¹,

Gall²,

Kelly³

et al. 1974

J. Clin. Invest.

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 88%

Transmissible Gastroenteritis MECHANISMS RESPONSIBLE FOR DIARRHEA IN AN ACUTE VIRAL ENTERITIS IN PIGLETS

Butler¹,

Gall²,

Kelly³

et al. 1974

J. Clin. Invest.

View full text Add to dashboard Cite

“…During the 1st h, it averaged 11.9+1.1 mV (mucosa negative). It was relatively stable, decreasing only by 13% in the succeeding 3 h. This is a value well within the range found for other intestinal segments (41)(42)(43)(44)(45)(46)(47)(48)(49). The magnitude of the PD was in the indicated range even 'A value of 1.0 for the reflection coefficient of mannitol is also supported by the following considerations:…”

Section: Methodssupporting

confidence: 83%

“…Most of the studies of net fluid and solute entry into the lumen have employed some kind of physical, chemical, or nervous stimulation which reverses the direction of the usual absorptive state of the epithelium (1)(2)(3). The "pathological" intestinal secretion associated with cholera has been intensively studied in recent years (4,5).…”

Section: Introductionmentioning

confidence: 99%

Some Characteristics of the Rabbit Vermiform Appendix as a Secreting Organ

Blackwood¹,

Bolinger²,

Lifson³

1973

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T It has been confirmed that the rabbit vermiform appendix secretes spontaneously at a relatively rapid rate (1-12 ml h-1; 1.40.24/Al*min' * cm-2). The electrolyte composition is similar to that of ileal fluids and independent of the secretory rate. The transmural potential difference is about 12 mV, mucosa negative. Of the major electrolytes, only HCO3-is secreted grossly against its electrochemical potential difference. This finding plus the low hydraulic (or osmotic) permeability (Lp) and high secretory pressures of the organ strongly suggest that the secretion is an active one. The passive permeability to Na+ and Clappears to be, at most, somewhat less than for small bowel. Permeability to mannitol was estimated at 2.5 X 1to7 cm.s'l. On the basis of reasonable assumptions and results with luminal test solutions of differing osmolarities, it was concluded that (a) the Lp of the appendiceal epithelium is in the lower range of values reported for small bowel and colon; (b) the Lp is higher for osmotic absorption than for osmotic secretion; and (c) the rate of spontaneous secretion is insensitive to luminal anisotonicity over a wide range of values. But sufficiently hypotonic solutions can reverse net secretion to net absorption, more by inhibiting spontaneous secretion than increasing osmotic absorption. The rabbit vermiform appendix appears to be a useful model for the elucidation of intestinal secretory processes. INTRODUCTIONAlthough numerous studies have increased our knowledge regarding the mechanisms of intestinal absorption,

show abstract

“…These findings are consistent with the view that fluid along with Na+ enters the lateral intercellular space from the mucosal solution by passing via the tight-junctions as has been suggested previously (Gupta et al 1978, Hill & Hill, 1978, see previous paper for discussion). The diffuse distribution of intercellular space enlargement is inconsistent with the view that intestinal secretion originates solely from the crypt cells (Hendrix & Bayless, 1970).…”

Section: Electro-osmotic Flow Via the Tight-junctionmentioning

confidence: 65%

Electrophysiological and electron‐microscopical correlations with fluid and electrolyte secretion in rabbit ileum.

Holman¹,

Naftalin²,

Simmons³

et al. 1979

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. The effects of theophylline and triaminopyrimidine on the passive permeability of Na+ and Cl-across sheets of rabbit ileum treated with 0-1 mM-ouabain were examined by determining the NaCl: mannitol dilution potentials, K+: Na+; choline: Na+ and S02-: Cl-biionic potentials. The results indicate (a) that triaminopyrimidine reduces paracellular Na+ and K+ permeability without affecting Cl-permeability and (b) that theophylline increases Cl-permeability without affecting Na+ permeability and (c) that neither theophylline nor triaminopyrimidine interfere with each other's action. This is further evidence consistent with separate routes for paracellular Na+ and Cl-movement. 2. Electrical resistance changes across sheets of actively transporting rabbit ileum were measured as a function of time in various conditions. Theophylline has a biphasic effect on resistance. Initially it decreases resistance from 56 Q cm2 (control) to 40 Q cm2. In the ensuing 30 min, resistance rises to 50 Q cm2; whereas it falls to 30 Q cm2 in controls.When theophylline is present, with triaminopyrimidine, or with galactose, no secondary rise in tissue resistance occurs. The initial decrease in resistance is consistent with a theophylline-dependent increase in Cl-conductance and the secondary rise in resistance may be attributed to collapse of the lateral intercellular space following leakage of NaCl and fluid into the mucosal solution.3. Electron microscopy of glutaraldehyde-fixed tissue confirms the above views, since, with theophylline present, the lateral intercellular spaces are collapsed and with both triaminopyrimidine and theophylline, or both theophylline and 20 mMgalactose present the spaces remain open.4. It is shown in the Discussion that the theophylline-or choleragen-induced increase in passive Cl-permeability of the mucosal border is the only requirement necessary to explain the increase in electrogenic Cl-secretion, the increase in shortcircuit current, as well as neutral secretion of NaCl and net fluid secretion.

show abstract

Digestion: Intestinal Secretion

Cited by 93 publications

References 32 publications

Transmissible Gastroenteritis MECHANISMS RESPONSIBLE FOR DIARRHEA IN AN ACUTE VIRAL ENTERITIS IN PIGLETS

Transmissible Gastroenteritis MECHANISMS RESPONSIBLE FOR DIARRHEA IN AN ACUTE VIRAL ENTERITIS IN PIGLETS

Some Characteristics of the Rabbit Vermiform Appendix as a Secreting Organ

Electrophysiological and electron‐microscopical correlations with fluid and electrolyte secretion in rabbit ileum.

Contact Info

Product

Resources

About