Difluorinated Curcumin: A Promising Curcumin Analogue with Improved Anti-Tumor Activity and Pharmacokinetic Profile

Momtazi, Amir Abbas; Sahebkar, Amirhossein

doi:10.2174/1381612822666160527113501

Cited by 151 publications

(63 citation statements)

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“…It is applied in Ayurvedic medicine for treatment of inflammatory diseases for a long time. This plant and its bioactive polyphenols, curcuminoids, have been shown to exert several therapeutic actions including anti-asthmatic, 34 antioxidant, [181][182][183] immunomodulatory, 35 hepatoprotective, 36,37 antitumor, 38,40,41 and anti-inflammatory 39,184,185 activities.…”

Section: Curcuma Longamentioning

confidence: 99%

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

et al. 2019

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Traumatic brain injury (TBI) is the most prevalent health problem affecting all age groups, and leads to many secondary problems in other organs especially kidneys, gastrointestinal tract, and heart function. In this review, the search terms were TBI, fluid percussion injury, cold injury, weight drop impact acceleration injury, lateral fluid percussion, cortical impact injury, and blast injury. Studies with Actaea racemosa, Artemisia annua, Aframomum melegueta, Carthamus tinctorius, Cinnamomum zeylanicum, Crocus sativus, Cnidium monnieri, Curcuma longa, Gastrodia elata, Malva sylvestris, Da Chuanxiong Formula, Erigeron breviscapus, Panax ginseng, Salvia tomentosa, Satureja khuzistanica, Nigella sativa, Drynaria fortune, Dracaena cochinchinensis, Polygonum cuspidatum, Rosmarinus officinalis, Rheum tanguticum, Centella asiatica, and Curcuma zedoaria show a significant decrease in neuronal injury by different mechanisms such as increasing superoxide dismutase and catalase activities, suppressing nuclear factor kappa B (NF‐κB), interleukin 1 (IL‐1), glial fibrillary acidic protein, and IL‐6 expression. The aim of this study was to evaluate the neuroprotective effects of medicinal plants in central nervous system pathologies by reviewing the available literature.

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Section: Curcuma Longamentioning

confidence: 99%

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

et al. 2019

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“…Unlike usual curcumin, new technologies are planned to deliver therapeutic agents especially to tumors and improve anti-cancerous effects, thus avoiding systemic and unpleasant effects. 93,94 Besides, most of the point of views above were dated from in vitro and limited in vivo research including some clinical trials. There is a long way to go before curcumin can be utilized in clinical cancer treatment strategy.…”

Section: Questions and Prospectsmentioning

confidence: 99%

Curcumin inhibits cancer progression through regulating expression of microRNAs

et al. 2017

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Curcumin, a major yellow pigment and spice in turmeric and curry, is a powerful anti-cancer agent. The anti-tumor activities of curcumin include inhibition of tumor proliferation, angiogenesis, invasion and metastasis, induction of tumor apoptosis, increase of chemotherapy sensitivity, and regulation of cell cycle and cancer stem cell, indicating that curcumin maybe a strong therapeutic potential through modulating various cancer progression. It has been reported that microRNAs as small noncoding RNA molecules are related to cancer progression, which can be regulated by curcumin. Dysregulated microRNAs play vital roles in tumor biology via regulating expressions of target genes and then influencing multiple cancer-related signaling pathways. In this review, we focused on the inhibition effect of curcumin on various cancer progression by regulating expression of multiple microRNAs. Curcumin-induced dysregulation of microRNAs may activate or inactivate a set of signaling pathways, such as Akt, Bcl-2, PTEN, p53, Notch, and Erbb signaling pathways. A better understanding of the relation between curcumin and microRNAs may provide a potential therapeutic target for various cancers.

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“…It has been identified that curcumin has a low intestinal absorption and quick metabolism in the liver and excessive excretion in the feces. Consequently, low‐water solubility and extensive first‐pass intestinal and liver metabolism leads to the low oral bioavailability of curcumin and limit its pharmacological effects (Abbas Momtazi & Sahebkar, ). Various delivery systems have been developed to enhance water solubility and systemic bioavailability of curcumin.…”

Section: Introductionmentioning

confidence: 99%

Potential therapeutic effects of curcumin in gastric cancer

Barati

Momtazi‐Borojeni

Majeed

et al. 2018

Journal Cellular Physiology

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Despite recent advancements in understanding of the biology of gastric cancer, treatment of patients with advanced gastric cancer remains a major problem. Among different type of phytochemicals, curcumin, a welltable -known phytochemical, has been shown to be a promising cancer chemopreventive agent. Pharmacokinetics, safety, and efficacy of curcumin have been evaluated in several clinical trials against numerous diseases, and for the treatment of human cancer. In the present review, we have collected in vitro and in vivo investigations and studied the chemosensitizing and anticancer effects of curcumin against the gastric cancer cells. In summary, curcumin has been found to have efficient chemosensitizing effect and also inhibits viability, proliferation, and migration of gastric cancer cells mainly via cell cycle arrest and induction of apoptosis by both mitochondrial-dependent and -independent pathways.

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Difluorinated Curcumin: A Promising Curcumin Analogue with Improved Anti-Tumor Activity and Pharmacokinetic Profile

Abstract: This review presents an overview of the findings on metabolism and pharmacological activities of CDF, and also highlights potential opportunities to use this novel curcumin analogue in the treatment of cancer.

Cited by 151 publications

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Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Medicinal plants in traumatic brain injury: Neuroprotective mechanisms revisited

Curcumin inhibits cancer progression through regulating expression of microRNAs

Potential therapeutic effects of curcumin in gastric cancer

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