Diffusivity Measurements Differentiate Benign from Malignant Lesions in Patients with Peripheral Neuropathy or Plexopathy

Yuh, Esther L.; Palrecha, S. Jain; Lagemann, G. M.; Kliot, Michel; Weinstein, P R; Barbaro, Nicholas M.; Chin, Cynthia T.

doi:10.3174/ajnr.a4080

Cited by 32 publications

(12 citation statements)

References 25 publications

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“…1.30 Â 10 À3 mm 2 /sec. 37 The relatively high ADC value of this particular vagal nerve neurofibroma (2 Â 10 À3 mm 2 /sec) was supportive of benign histology, correlating with the final pathology.…”

Section: Discussionmentioning

confidence: 60%

Large Cervical Vagus Nerve Tumor in a Patient with Neurofibromatosis Type 1 Treated with Gross Total Resection: Case Report and Review of the Literature

Bray

Chan

Chin

et al. 2016

J Brachial Plex Peripher Nerve Inj

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Neurofibromas are benign peripheral nerve sheath tumors that occur commonly in individuals with neurocutaneous disorders such as neurofibromatosis type 1. Vagal nerve neurofibromas, however, are a relatively rare occurrence. We present the case of a 22-year-old man with neurofibromatosis type 1 with a neurofibroma of the left cervical vagal nerve. The mass was resected through an anterior approach without major event. In the postoperative course, the patient developed left vocal cord paralysis treated with medialization with injectable gel. We then present a comprehensive review of the literature for surgical resection of vagal nerve neurofibromas.

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Section: Discussionmentioning

confidence: 60%

Large Cervical Vagus Nerve Tumor in a Patient with Neurofibromatosis Type 1 Treated with Gross Total Resection: Case Report and Review of the Literature

Bray

Chan

Chin

et al. 2016

J Brachial Plex Peripher Nerve Inj

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“…We excluded reviews, spinal cord studies and animal or in vivo studies. Our review identified a total of 35 articles: 24 DTI studies and 11 diffusionweighted MR neurography studies [31][32][33][34][35][36][37][38][39][40][41] . The number of lumbar nerve DTI studies has sharply increased in recent years ( Fig.…”

Section: Trends In Clinical Mr Neuroimaging Of Lumbar Nervesmentioning

confidence: 99%

Recent advances in magnetic resonance neuroimaging of lumbar nerve to clinical applications: A review of clinical studies utilizing Dffusion Tensor Imaging and Diffusion-weighted magnetic resonance neurography

Eguchi

Kanamoto

Oikawa³

et al. 2017

Spine Surg Relat Res

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Abstract:Much progress has been made in neuroimaging with Magnetic Resonance neurography and Diffusion Tensor Imaging (DTI) owing to higher magnetic fields and improvements in pulse sequence technology. Reports on lumbar nerve DTI have also increased considerably.Many studies have shown that the use of DTI in lumbar nerve lesions, such as lumbar foraminal stenosis and lumbar disc herniation, makes it possible to capture images of interruptions of tractography at stenotic sties, enabling the diagnosis of stenosis. DTI can also reveal significant decreases in fractional anisotropy (FA) with significant increases in apparent diffusion coefficient (ADC) values in compression lesions.FA values have higher accuracy than ADC values. Furthermore, strong correlations exist between FA values and indications of neurological severity, including the Japanese Orthopedic Association (JOA) score, the Oswestry Disability Index (ODI), and the Roland-Morris Disability Questionnaire (RDQ) in patients with lumbar disc herniation-induced radiculopathy.Most lumbar DTI has become 3T; 3T MRI has made it possible to take high-resolution DTI measurements in a short period of time. However, increased motion artifacts in the magnetic susceptibility effect lead to signal irregularities and image distortion. In the future, high-resolution DTI with reduced field-of-view may become useful in clinical applications, since visualization of nerve lesions and quantification of DTI parameters could allow more accurate diagnoses of lumbar nerve dysfunctions. Future translational studies will be necessary to successfully bring MR neuroimaging of lumbar nerve into clinical use.

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“…criteria suggesting malignancy are heterogeneous enhancement or a sudden change in size and/or pattern of enhancement on follow-up examinations. As reported by Yuh et al, 37 diffusivity measurements may facilitate differentiation of benign from malignant tumors and from postradiation plexopathy. Using mean ADC values of 1.85 Â 10 3 mm 2 /s) for the diagnosis of benign lesions and 0.90 Â 10 3 mm 2 /s for the diagnosis of malignant tumors, Yuh et al were able to classify malignant and benign lesions correctly.…”

Section: Tumorsmentioning

confidence: 68%

“…However, because benign lesions and postradiation changes had similar ADC values, differentiation between the latter two conditions was not possible based on diffusivity measurements alone. 37 As mentioned earlier, MRI spectroscopy 18 can be useful for differentiating benign from malignant tumors because it allows detection of trimethylamine; nevertheless, quantification of trimethylamine is necessary to increase method specificity. 18 Fluorodeoxyglucose (FDG) PET/CT and, more recently, PET/MRI are good additions and should be performed in cases of suspected metastatic plexus involvement because high FDG uptake is typically seen in malignant tumors; absent or low FDG uptake, however, does not exclude the presence of a metastatic lesion.…”

Section: Tumorsmentioning

confidence: 99%

Three-Dimensional MR Imaging of the Brachial Plexus

Vargas

Gariani

Delattre

et al. 2015

Semin Musculoskelet Radiol

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Pathologic conditions of the brachial plexus often result in serious and disabling complications. With the increasing availability and use of new and powerful MRI sequences and coils, understanding and assessment of the complex anatomy and pathology of the brachial plexus have been greatly facilitated. These new technical developments have led to an improved assessment of brachial plexus lesions, thereby improving patient care. In this article we describe various MRI techniques for the evaluation of the brachial plexus obtained at 1.5 T and 3 T, and we explain differences and similarities between sequences and protocols performed on MRI equipment from different vendors. The main characteristics of pathologic conditions affecting the brachial plexus are discussed and illustrated, as well as their differential diagnoses, with an emphasis on key imaging findings and relevance for patient management. Pitfalls related to suboptimal technique and image interpretation are also addressed.

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Diffusivity Measurements Differentiate Benign from Malignant Lesions in Patients with Peripheral Neuropathy or Plexopathy

Cited by 32 publications

References 25 publications

Large Cervical Vagus Nerve Tumor in a Patient with Neurofibromatosis Type 1 Treated with Gross Total Resection: Case Report and Review of the Literature

Large Cervical Vagus Nerve Tumor in a Patient with Neurofibromatosis Type 1 Treated with Gross Total Resection: Case Report and Review of the Literature

Recent advances in magnetic resonance neuroimaging of lumbar nerve to clinical applications: A review of clinical studies utilizing Dffusion Tensor Imaging and Diffusion-weighted magnetic resonance neurography

Three-Dimensional MR Imaging of the Brachial Plexus

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