Diffusion-weighted single-shot echoplanar MR imaging for liver disease.

Kim, T; Murakami, Takamichi; Takahashi, Sanae; Hori, Masatoshi; Tsuda, Kazuki; Nakamura, Hajime

doi:10.2214/ajr.173.2.10430143

Cited by 328 publications

(290 citation statements)

References 7 publications

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“…Reduced ADC values have been reported for most malignant tumors (23,34,35) and are thought to be due to cellular membranes impeding the mobility of water protons (36,38). In theory, any condition that decreases the extracellular space should decrease ADC values in the presence of hypercellularity due to an increase in the number of cells and therefore membranes per unit of volume, with consequent ''restricted diffusion'' (17).…”

Section: Discussionmentioning

confidence: 99%

Diffusion‐weighted images differentiate benign from malignant thyroid nodules

Erdem

Muammer

et al. 2009

Magnetic Resonance Imaging

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Purpose:To reveal the possible role of diffusion-weighted images (DWI) in the differential diagnosis of benign and malignant thyroid nodules by comparing the results of fine-needle aspiration cytology (FNAC). Materials and Methods:In an 18-month period (December 2005 to May 2007), 27 cases with benign thyroid nodules with a total of 52 benign nodules, nine cases with thyroid gland malignancy, and 24 healthy control cases were included in the study. Cases that were indicated to undergo to FNAC examination and sent by a clinician for biopsy to the radiology unit were included in the study to assess the cytopathologic confirmation of the clinic, ultrasonographic, and magnetic resonance imaging (MRI) findings. Results:The mean apparent diffusion coefficient (ADC) values of thyroid nodules were 2745.3 6 601.1 Â 10 À6 mm 2 /s (1605-3899 Â 10 À6 mm 2 /s) in the benign group and 695.2 6 312.5 Â 10 À6 mm 2 /s (165-1330 Â 10 À6 mm 2 /s) in the malignant group. Normal thyroid tissues had mean ADC values of 1344.1 6 276.4 Â 10 À6 mm 2 /s (1015-1764 Â 10 À6 mm 2 /s). The ADC values of three subgroups were significantly different (P ¼ 0.0001). A reduced ADC was observed in most types of malignant tumors due to the consequent decrease of the extracellular extravascular space. Conclusion:Our preliminary results showed that ADC values of nodules may provide useful data about the nature of a thyroid nodule.

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Section: Discussionmentioning

confidence: 99%

Diffusion‐weighted images differentiate benign from malignant thyroid nodules

Erdem

Muammer

et al. 2009

Magnetic Resonance Imaging

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“…Taouli et al first showed that ADC values can be used to differentiate between benign and malignant lesions in liver. 20,21 After this, few studies 23,24 were done to differentiate between benign and malignant hepatic lesions and also to differentiate between various grades of HCC. Nasu et al, 19 Piana et al, 15 and Saito et al 25 showed that there exists no relationship between ADC values and histopathological grades of HCC, whereas Heo et al 26 and Nishie et al 27 said that the ADC values of HCC had an inverse correlation with the degree of differentiation.…”

Section: Role Of Diffusion Weighted Imaging For Hepatocellular Carcinmentioning

confidence: 99%

Role of Diffusion Weighted Imaging (DWI) for Hepatocellular Carcinoma (HCC) Detection and its Grading on 3T MRI: A Prospective Study

Shankar

Kalra

Bhatia

et al. 2016

Journal of Clinical and Experimental Hepatology

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Background: Limited studies have evaluated the role of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) for histologically grading the hepatocellular carcinoma (HCC). Objective: To compare the efficacy of DWI with dynamic contrast enhanced magnetic resonance (DCEMR) in detection of HCC in cirrhosis, and to evaluate whether DWI can be used instead of DCEMR. Methods: 20 patients of either sex with cirrhosis and suspected of having HCC on screening USG were included in this prospective study approved by the Institutional Ethics Committee. All patients underwent DCEMR of the abdomen on 3T scanner and fine needle aspiration of the lesions. MR protocol included T1WI, T2WI, DWI, and dynamic CEMR. The results of diffusion weighted imaging were compared with DCEMR to find the efficacy of DWI vis-à-vis CEMR. Results: DWI had a sensitivity and specificity of 100%, for diagnosis of lesions in cases having single lesion on CEMR, and sensitivity of 75% and specificity of 100% for diagnosis of lesions in cases having multiple lesions. There was a decreasing trend of ADC values with increasing grade of the tumor; however, the decreasing trend was not statistically significant. A cut-off ADC value of 0.8705 resulted in a sensitivity of 75% and specificity of 50% for differentiating between welldifferentiated and other grades of HCC. Conclusion: DWI can be used as an alternative for the detection and characterization of HCC, especially in patients with impaired renal function or contrast allergies precluding the use of contrast. In addition, DWI with ADC measurement may be helpful for non-invasive and preoperative prediction of the degree of differentiation of HCC. ( J CLIN EXP HEPATOL 2016;6:303-310)

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“…[1][2][3] In particular, using diŠusion-weighted single-shot echoplanar imaging (EPI) and SENSE (SENSE-DWI) simultaneously is especially helpful in screening hepatic metastasis. 4 However, the optimal imaging parameters of this sequence, such as simultaneous respiratory triggering, have not been established.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Simultaneous Use of Respiratory Triggering in Diffusion-weighted Imaging of the Liver

Nasu

Kuroki

Sekiguchi

et al. 2006

MRMS

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Objective: To determine the eŠect of simultaneous use of respiratory triggering in hepatic diŠusion-weighted imaging (DWI), we compared DWI with respiratory triggering (RT-DWI) and DWI under free breathing (FB-DWI) in terms of relative contrast between hepatic tumor and surrounding liver parenchyma, apparent diŠusion coe‹cient (ADC) measurement, and frequency of respiratory misregistration. Materials and Methods: Thirty patients (21 men, 9 women, aged 25 to 80 years) with liver metastasis or hepatocellular carcinoma in the right hepatic lobe were examined with RT-and FB-DWI. In patients having multiple tumors, up to 3 lesions were selected by mutual agreement of 2 diagnostic radiologists. Finally, 59 nodules were selected for evaluation. Relative contrast ratio (RCR) between the lesions and surrounding parenchyma and ADC were measured in each hepatic lesion in each sequence. The diŠerences in RCR and ADC between RT-and FB-DWI were statistically analyzed using Wilcoxon's signed rank test. The frequency of respiratory misregistration advents in each sequence was visually evaluated by the 2 diagnostic radiologists and assessed using McNemar's test.Results: RCRs were signiˆcantly higher in RT-than in FB-DWI (Pº0.001). The diŠer-ence in ADC between the 2 sequences was not signiˆcant. However, ADCs tended to be more scattered in FB-than in RT-DWI. The frequency of respiratory misregistration advents was signiˆcantly higher in FB-than in RT-DWI.Conclusion: FB-was inferior to RT-DWI in both contrast between tumors and surrounding liver parenchyma and in accuracy of ADC measurement as far as the numbers of excitation in each sequence were the same. For preoperative examination of hepatic resection, RT-is more suitable than FB-DWI.

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Diffusion-weighted single-shot echoplanar MR imaging for liver disease.

Cited by 328 publications

References 7 publications

Diffusion‐weighted images differentiate benign from malignant thyroid nodules

Diffusion‐weighted images differentiate benign from malignant thyroid nodules

Role of Diffusion Weighted Imaging (DWI) for Hepatocellular Carcinoma (HCC) Detection and its Grading on 3T MRI: A Prospective Study

The Effect of Simultaneous Use of Respiratory Triggering in Diffusion-weighted Imaging of the Liver

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