Diffusion-Weighted MRI of Peritoneal Tumors: Comparison With Conventional MRI and Surgical and Histopathologic Findings—A Feasibility Study

Low, Russell N.; Sebrechts, Christopher; Barone, Robert M.; Müller, W

doi:10.2214/ajr.08.1753

Cited by 192 publications

(106 citation statements)

References 36 publications

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“…Diagnostic imaging is used to determine the suitability of the patient for surgery by assessing the primary tumor or by describing the disease volume and extent (7,8). DWI, as a functional MRI technique, provides non-invasive and high-resolution information on tissue characteristics based on molecular water diffusion properties, and the imaging output is useful to determine tissue microstructure, density, microcirculation and cellular organization (9,11,33). Several studies describe a close association between cell density and ADC values (16,(33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

“…Diffusion weighted imaging (DWI) is a non-invasive technique based on molecular water diffusion properties, and may be used to characterize tissue architecture based on microstructure, cellular density, microcirculation and cell organization (9)(10)(11). DWI has been demonstrated to be more accurate compared with computed tomography (CT) for characterizing the sites of implants of ovarian cancers, including metastases to the liver, lungs, kidneys, uterus and pancreas (12,13).…”

Section: Introductionmentioning

confidence: 99%

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Diffusion weighted imaging for the differential diagnosis of benign vs. malignant ovarian neoplasms

et al. 2016

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Abstract. In order to assess the diagnostic accuracy of diffusion weighted imaging (DWI) in differentiating between benign and malignant ovarian neoplasms, a systemic meta-analysis was conducted. Relevant studies were retrieved from scientific literature databases, including the PubMed, Wiley, EBSCO, Ovid, Web of Science, Wanfang, China National Knowledge Infrastructure and VIP databases. Following a multi-step screening and study selection process, the relevant data was extracted for use in the present study. Statistical analyses were performed using Meta-disc software version 1.4 and STATA statistical software version 12.0. A total of 285 articles were retrieved from the database searches. Following a careful screening process, 10 case-control studies were selected for the present meta-analysis. The 10 studies investigated the efficacy of DWI in diagnosing ovarian neoplasms, and included a combined total of 1,159 subjects, of which 559 patients had malignant lesions and 600 had benign lesions. The results showed that the pooled sensitivity, pooled specificity, pooled positive likelihood ratio, pooled negative likelihood ratio, pooled diagnostic odds ratio (DOR) and area under the curve of the summary receiver operating characteristics curve of DWI for differentiating between benign and malignant ovarian neoplasms were 0. 93, 0.89, 7.58, 0.10, 85.33 and 0.95, respectively

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diffusion weighted imaging for the differential diagnosis of benign vs. malignant ovarian neoplasms

et al. 2016

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“…Fujii et al [47] showed sensitivity and specificity of 90% and 95.5% respectively for diffusion weighted imaging in detecting such deposits. In another study done by Low et al [48] combined conventional and DWI imaging showed better sensitivity and accuracy than DWI alone …”

Section: Peritoneal Depositsmentioning

confidence: 92%

Diffusion weighted imaging in gynecological malignancies - present and future

Manoharan¹,

Das²,

Aggarwal³

et al. 2016

WJR

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The management of gynaecological malignancies has undergone a significant change in recent years with our improved understanding of cancer biogenetics, development of new treatment regimens and enhanced screening. Due to the rapid blooming of newer methods and techniques in gynaecology, surgery and oncology the scope and the role of imaging has also widened. Functional imaging in the form of diffusion weighted imaging (DWI) has been recently found to be very useful in assessing various tumours. Its ability to identify changes in the molecular level has dramatically changed the diagnostic approach of radiologists which was solely based on morphological criteria. It can improve the diagnostic accuracy of conventional magnetic resonance imaging, lend a hand in assessing tumour response to treatment regimens and detect tumour recurrence with better spatial resolution, negative radiation and diagnostic accuracy compared to positron emission tomography scan. The ability to quantify the diffusion has also lead to potential prediction of tumour aggressiveness and grade which directly correlate with the patient prognosis and management. Hence, it has become imperative for a radiologist to understand the concepts of DWI and its present and evolving role. In this article we present a brief description of the basics of DWI followed by its role in evaluation of female gynaecological malignancies. Core tip: With rapidly evolving strategies in the management of the gynaecological malignancies today there is an increasing role of imaging to keep up with the pace of development and develop newer techniques which help in better management of the patient. Diffusion weighted imaging (DWI) is one such modality which helps in detecting changes at the molecular level and hence can help in better diagnosis of early cancers as well as in assessing response to treatment.

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“…When combined with conventional MRI, DWI has been shown to increase the sensitivity(90 %) and specificity( 95.5 %) [24] Site specific disease, particularly small deposits in mesentery, serosa of bowel, peri-hepatic and peri-pancreatic areas are better evaluated by DWI MRI [25] (Fig. 2).…”

Section: Diffusion Weighted Mri (Dwi)mentioning

confidence: 99%

“…These lesions can be demonstrated by both CT and DWI MRI. [25] Pelvis The uterus, bladder and rectum are partially covered by the peritoneum. The recto vesical space in males and the rectovaginal space in females form the most dependent portions of the pelvic cavity and therefore are frequent sites of metastatic disease.…”

Section: Para Colic Guttersmentioning

confidence: 99%

Role of Imaging in Peritoneal Surface Malignancies

Krishnamurthy

Balasubramaniam

2016

Indian J Surg Oncol

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Diffusion-Weighted MRI of Peritoneal Tumors: Comparison With Conventional MRI and Surgical and Histopathologic Findings—A Feasibility Study

Abstract: Adding DWI to routine MRI improves the sensitivity and specificity for depicting peritoneal metastases. Breath-hold DWI is now routinely used in all oncology patients referred for abdominal MRI at our institution.

Cited by 192 publications

References 36 publications

Diffusion weighted imaging for the differential diagnosis of benign vs. malignant ovarian neoplasms

Diffusion weighted imaging for the differential diagnosis of benign vs. malignant ovarian neoplasms

Diffusion weighted imaging in gynecological malignancies - present and future

Role of Imaging in Peritoneal Surface Malignancies

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