Diffusion-weighted MRI in the characterization of cystic pancreatic lesions: usefulness of ADC values

Boraschi, Piero; Donati, Francescamaria; Gigoni, R; Salemi, Simonetta; Bartolozzi, Carlo; Falaschi, Fabio

doi:10.1016/j.mri.2010.06.031

Cited by 30 publications

(42 citation statements)

References 22 publications

(45 reference statements)

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“…Contrary to the studies mentioned above, other studies reported higher ADC values for mucin-producing cysts compared to serous ones (25-27). However, the difference in ADC values between the two groups was statistically significant only in the study by Boraschi et al (26). As highlighted, the small sample size, particularly for serous cysts, is a main limitation of most of the previous studies (21-23, 25,26).…”

Section: Introductionmentioning

confidence: 84%

Diffusion-Weighted Magnetic Resonance Imaging in Distinguishing Between Mucin-Producing and Serous Pancreatic Cysts

Pozzessere

Gutiérrez

Corona‐Villalobos

et al. 2016

Journal of Computer Assisted Tomography

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Objective To evaluate the feasibility and the reproducibility of diffusion-weighted imaging (DWI) in distinguishing between mucin-producing and serous pancreatic cysts. Methods Forty-four pancreatic cysts (43 patients; 27 females; mean age 57 years-old; 26 mucin-producing cysts; 18 serous cysts) underwent histological examination or cyst analysis after DW-MRI were retrospectively reviewed. Three blinded readers independently evaluated SI and ADC. Intra-observer and inter-observer agreements were calculated. Fisher's exact test and Welch's t test were used to compare SI and ADC values respectively, to pathological results. ROC analysis was used to determine diagnostic accuracy of various thresholds for ADC. A p value < 0.05 was considered statistically significant. Results Mean ADC value of the mucin-producing cysts was 3.26 ×10−3 mm2/sec, 3.27 ×10−3 mm2/sec and 3.35 ×10−3 mm2/sec for the three readers, respectively. Mean ADC value of the serous cysts was 2.86 ×10−3 mm2/sec, 2.85 ×10−3 mm2/sec and 2.85 ×10−3 mm2/sec for the three readers, respectively. Difference in ADC values between the two cyst groups was 12.4%, 12.9% and 14.8% for the three readers, respectively (p<0.001). Intra-observer and inter-observer agreement was excellent. A threshold ADC of 3×10−3 mm2/sec resulted in correct identification of cysts in 77-81% of cases, with sensitivity and specificity ranging between 84-88% and 66-72%, respectively. Conclusions DWI may be a helpful tool in distinguishing between mucin-producing and serous pancreatic cysts.

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Section: Introductionmentioning

confidence: 84%

Diffusion-Weighted Magnetic Resonance Imaging in Distinguishing Between Mucin-Producing and Serous Pancreatic Cysts

Pozzessere

Gutiérrez

Corona‐Villalobos

et al. 2016

Journal of Computer Assisted Tomography

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“…Boraschi et al found that the mean ADC values of different types of pancreatic lesions (intraductal papillary mucinous tumor (IPMT), mucinous cystoadenoma, serous cystoadenoma, pseudocyst) were significantly different (P<0.05). Therefore, the authors concluded that DWI-MRI may be helpful in the differential diagnosis of cystic pancreatic lesions [4]. In the work of Sandrasegaran et al, ADC values were found to be helpful in deciding the malignant potential of IPMT.…”

Section: Radiological Work-up For Correct Indications For Surgerymentioning

confidence: 99%

Pancreatic Adenocarcinoma

Filauro

Rollandi

Ruggieri

et al. 2013

What’s New in Surgical Oncology

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“…The role of diffusion-weighted imaging and apparent diffusion coefficient remains controversial in the characterization of cystic pancreatic lesions. [108][109][110] …”

Section: Mrimentioning

confidence: 99%