Diffusion‐weighted MRI as an adjunct to mammography in women under 50 years of age: An initial study

Kazama, Toshiki; Kuroki, Yoshio; Kikuchi, Mari; Sato, Yasunori; Nagashima, Takeshi; Miyazawa, Yasumasa; Sakakibara, Masahiro; Kaneoya, Katsuhiko; Makimoto, Yumi; Hashimoto, Hideyuki; Motoori, Ken; Takano, Hideyuki

doi:10.1002/jmri.23626

Cited by 42 publications

(34 citation statements)

References 26 publications

(61 reference statements)

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“…There may also be a role for DWI as an alternative to contrast‐enhanced MRI for breast cancer screening . Early investigations showed many mammographically and clinically occult breast cancers are visible on DWI and exhibit low ADC values, Figure .…”

Section: Clinical Applicationsmentioning

confidence: 99%

Diffusion-weighted breast MRI: Clinical applications and emerging techniques

Partridge

Nissan²,

Rahbar

et al. 2016

J. Magn. Reson. Imaging

267

258

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Diffusion weighted MRI (DWI) holds potential to improve the detection and biological characterization of breast cancer. DWI is increasingly being incorporated into breast MRI protocols to address some of the shortcomings of routine clinical breast MRI. Potential benefits include improved differentiation of benign and malignant breast lesions, assessment and prediction of therapeutic efficacy, and non-contrast detection of breast cancer. The breast presents a unique imaging environment with significant physiologic and inter-subject variations, as well as specific challenges to achieving reliable high quality diffusion weighted MR images. Technical innovations are helping to overcome many of the image quality issues that have limited widespread use of DWI for breast imaging. Advanced modeling approaches to further characterize tissue perfusion, complexity, and glandular organization may expand knowledge and yield improved diagnostic tools.

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Section: Clinical Applicationsmentioning

confidence: 99%

Diffusion-weighted breast MRI: Clinical applications and emerging techniques

Partridge

Nissan²,

Rahbar

et al. 2016

J. Magn. Reson. Imaging

267

258

View full text Add to dashboard Cite

show abstract

“…Intravoxel incoherent motion analysis on women with breast cancer has been performed by Sigmund et al , and these studies have described a biexponential shape of the diffusion curve in breast lesions. In women under 50, who most commonly have heterogeneously dense breast tissue, Kazama et al demonstrate DWI using b‐values of 0 and 800, combined with mammography results in significant improvement in malignancy sensitivity of 93% versus mammography alone of 64% with insignificant specificity loss (85% versus 92%). Future studies examining perfusion, and diffusion ADC values in addition to mammography would be beneficial to ascertain the possibility for developing improved noninvasive lesion detection.…”

Section: Dwi Body Applicationsmentioning

confidence: 99%

Whole body MRI: Improved lesion detection and characterization with diffusion weighted techniques

Attariwala

Picker

2013

Magnetic Resonance Imaging

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Diffusion-weighted imaging (DWI) is an established functional imaging technique that interrogates the delicate balance of water movement at the cellular level. Technological advances enable this technique to be applied to whole-body MRI. Theory, b-value selection, common artifacts and target to background for optimized viewing will be reviewed for applications in the neck, chest, abdomen, and pelvis. Whole-body imaging with DWI allows novel applications of MRI to aid in evaluation of conditions such as multiple myeloma, lymphoma, and skeletal metastases, while the quantitative nature of this technique permits evaluation of response to therapy. Persisting signal at high b-values from restricted hypercellular tissue and viscous fluid also permits applications of DWI beyond oncologic imaging. DWI, when used in conjunction with routine imaging, can assist in detecting hemorrhagic degradation products, infection/abscess, and inflammation in colitis, while aiding with discrimination of free fluid and empyema, while limiting the need for intravenous contrast. DWI in conjunction with routine anatomic images provides a platform to improve lesion detection and characterization with findings rivaling other combined anatomic and functional imaging techniques, with the added benefit of no ionizing radiation.

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“…Prior studies [15,16] have evaluated whether breast density can influence DWI with the hope that this type of MR sequences, without contrast medium, could be used to screen women with dense breasts in whom mammography is less effective. Our study was undertaken to evaluate if both the amount of fibroglandular breast tissue (FGT) and the background enhancement (BPE) influence the detection of lesions and their quantitative analysis in DWI.…”

Section: Introductionmentioning

confidence: 99%