Diffusion-weighted MR imaging of bone marrow: differentiation of benign versus pathologic compression fractures.

Baur, Andrea; Stäbler, Axel; Brüning, R.; Bartl, Reiner; Krödel, A.; Reiser, Maximilian; Deimling, M.

doi:10.1148/radiology.207.2.9577479

Cited by 401 publications

(214 citation statements)

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“…In a study of benign and pathologic spinal compression fractures using SSFP DWI, Baur et al [25] reported that all malignant compression fractures were hyperintense to normal marrow, whereas most benign compression fractures were hypointense to normal marrow. However, a subsequent study by Castillo et al [26] showed no advantage of DWI in the detection and characterization of vertebral metastases compared with T1-weighted imaging; metastases were hypointense to normal marrow in 3 out of 5 patients with focal disease and 5 out of 10 patients with multiple lesions.…”

Section: Fat and Water Contentmentioning

confidence: 99%

Magnetic resonance imaging of bone marrow in oncology, Part 1

Hwang

Panicek

2007

Skeletal Radiol

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Magnetic resonance imaging plays an integral role in the detection and characterization of marrow lesions, planning for biopsy or surgery, and post-treatment followup. To evaluate findings in bone marrow on MR imaging, it is essential to understand the normal composition and distribution of bone marrow and the changes in marrow that occur with age, as well as the basis for the MR signals from marrow and the factors that affect those signals. The normal distribution of red and yellow marrow in the skeleton changes with age in a predictable sequence. Important factors that affect MR signals and allow detection of marrow lesions include alterations in fat-water distribution, destruction of bony trabeculae, and contrast enhancement. This two-part article reviews and illustrates these issues, with an emphasis on the practical application of MR imaging to facilitate differentiation of normal marrow, tumor, and treatment-related marrow changes in oncology patients.

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Section: Fat and Water Contentmentioning

confidence: 99%

Magnetic resonance imaging of bone marrow in oncology, Part 1

Hwang

Panicek

2007

Skeletal Radiol

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“…MR sequences such as T1WI and CE-FS T1WI are valuable for the assessment of cranial bone marrow because they have high spatial resolution and tissue contrast. DW-MRI has been applied to vertebral bodies to differentiate between benign and malignant vertebral compression fractures 6 .…”

Section: Discussionmentioning

confidence: 99%

Kraniyal Kemik İliği Metastazlarında Difüzyon Ağırlıklı MR Görüntüleme

Alkan¹,

Peköz²,

Altınkaya³

2015

Cukurova Medical Journal

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Purpose: Diffusion-weighted MR imaging (DW-MRI) is generally applied to diagnose intra-axial brain pathologies such as parenchyma metastasis, abscesses, and infarcts in patients with systemic cancer. This study aimed to evaluate the DW-MRI findings in cranial bone marrow metastases to facilitate diagnosis. Material and Methods: Conventional MR imaging and DW-MRI findings of 57 patients with cranial bone marrow metastases were evaluated retrospectively. These images were evaluated by two neuroradiologists for lesion detection and lesion consciousness. Reader agreement was assessed by κ statistics. Results: Fifty-seven patients exhibited 113 cranial bone marrow metastases. The sensitivities of DW-MRI and the apparent diffusion coefficient to detect cranial bone metastasis for all types of primary malignancy were 86% and 90%, respectively. The sensitivities of T1-weighted imaging (T1WI), fluid attenuation inversion recovery, contrast-enhanced fat-suppressed (CE-FS) T1WI, and T2WI sequences to detect cranial bone metastasis were 93%, 90%, 89%, and 84%, respectively. Regarding lesion conspicuousness, DW-MRI was equivalent to CE-FS T1WI and equivalent or superior to non-contrast conventional sequences in most of the cranial bone marrow metastases. Interobserver agreement was excellent. Conclusions: DW-MRI is generally indicated not only to assess the diagnosis of parenchyma involvement, but also to discover the cranial bone marrow metastasis in patients with systemic cancer. Key words: Cranial bone marrow, metastases, brain MRI, diffusion-weighted MRI ÖZET Amaç: Difüzyon ağırlıklı MR (DAG-MR) görüntüleme genellikle sistemik kanserli hastalarda parankim metastazı, abse ve infart gibi intraaksiyel beyin patolojilerinin tanısında kullanılmaktadır. Bu çalışmada DAG -MR'nin kranial kemik iliği metastazlarının tanısındaki değeri araştırılmıştır. Materyal ve Metod: Kranial kemik iliği metastazı saptanan 57 hastanın konvansiyonel MR ve DAG-MR görüntüleri geriye dönük olarak değerlendirildi. Görüntüler 2 nöroradyolog tarafından lezyon saptanması ve göze çarpıcılığı açısından incelendi. Radyologların kappa uyumuna bakıldı. Bulgular: Elli yedi hastada toplam 113 kranial kemik iliği metastazı saptandı. DAG-MR ve ADC' nin lezyon saptama sensitivitesi sırasıyla %86 and %90 saptandı.T1, FLAIR, kontrastlı yağ baskılamalı T1 ve T2 ağırlıklı sekansların lezyon saptanmasında sensitivitesi sırasıyla %93, %90, % 89, ve %84 saptandı. DAG-MR'nin lezyon göze çarpıcılığı kontrastlı T1 ağırlıklı görüntülere eşit, diğer konvansiyonel sekanslara eşit ya da üstündü. Radyologların kappa uyumu mükemmeldi. Sonuç: DAG-MR sadece parankim tutulumunu değerlendirme değil, kemik iliği metastazlarını da değerlendirmede kullanılabilir Anahtar kelimeler: Kraniyal kemik iliği, metastaz, Beyin MR, Difüzyon MR

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“…Additionally, all patients underwent in-house MRI (T1-weighted sequence ± contrast, short tau inversion recovery sequence, axial and sagittal orientation) prior to vertebroplasty to assess the pattern of bone marrow involvement and vertebral and paravertebral tumor involvement and to detect the level(s) of vertebral edema in cases of multiple VCFs detected on CT (18).…”

Section: Imaging Workup and Guidancementioning

confidence: 99%