Diffusion-weighted MR imaging in gynecologic cancers

Motoshima, Shigenobu; Irié, Hiroyuki; Nakazono, Takahiko; Kamura, Toshiharu; Kudo, Sho

doi:10.3802/jgo.2011.22.4.275

Cited by 34 publications

(35 citation statements)

References 90 publications

(158 reference statements)

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“…Among the advantages of DWI is that it is a noninvasive technique and it does not require injection of contrast material, thus enabling its use in patients with renal dysfunction (11).…”

Section: Discussionmentioning

confidence: 99%

Diffusion-weighted magnetic resonance imaging in the assessment of ovarian masses with suspicious features: Strengths and challenges

Mansour

Wessam

Raafat

2015

The Egyptian Journal of Radiology and Nuclear Medicine

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Objective: To evaluate diagnostic performance of diffusion weighted imaging (DWI) in evaluating ovarian masses with suspicious features on magnetic resonance imaging (MRI). Patients and methods: Pelvic MRI and DWI assessed 235 complex and solid ovarian masses of suspicious MRI features. On DWI, scanning acquired by b values: 0, 500, 1000 and 1500. Analysis considered signal intensity (SI) at b1000 and the mean ADC values for the solid components of the masses. Results: Included masses proved benign in 75(32%), borderline (low potential malignancy) in 55(23.4%) and malignant in 105(44.6%). Restricted diffusion was observed in all of the invasive malignancy (57.1%, n = 105/184). Benign and borderline tumors with high DWI SI presented 15.2% and 27.7% respectively (P < 0.05). The mean ADC value was 1.2 + 0.34 · 10 À3 mm 2 /s, 1.1 + 0.06 · 10 À3 mm 2 /s, and 0.83 + 0.15 · 10 À3 mm 2 /s for benign, borderline and malignant masses respectively. The ADC values of malignant masses and benign masses with fibrous components showed no significant difference (P = 0.333). Significant difference was detected in those with fatty tissue (P = 0.002). Conclusion: DWI supported by conventional MRI data can confirm or exclude malignancy in suspicious ovarian masses. The combined analysis of quantitative and qualitative criteria and knowledge of the sequence pitfalls are required.

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“…Among the advantages of DWI is that it is a noninvasive technique and it does not require injection of contrast material, thus enabling its use in patients with renal dysfunction (11).…”

Section: Discussionmentioning

confidence: 99%

Diffusion-weighted magnetic resonance imaging in the assessment of ovarian masses with suspicious features: Strengths and challenges

Mansour

Wessam

Raafat

2015

The Egyptian Journal of Radiology and Nuclear Medicine

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“…By exploiting information about changes in proton mobility caused by the alteration of tissue cellularity and the integrity of the cellular membrane, tortuosity of extracellular space, and viscosity of fluids due to pathologic processes, DWI provides a tissue contrast that is different from that made with conventional T1-weighted (T1WI) and T2-weighted images (T2WI). It can be used to characterize highly cellular and acellular regions of tumors, distinguish cystic from solid regions, as well as the change in cellularity within the tumor over time [ 19 – 21 ].…”

Section: Discussionmentioning

confidence: 99%

Time-window of early detection of response to concurrent chemoradiation in cervical cancer by using diffusion-weighted MR imaging: a pilot study

et al. 2015

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BackgroundTo investigate the feasibility of DWI in evaluating early therapeutic response of uterine cervical cancer to concurrent chemoradiation (CCR) and establish optimal time window for early detection of treatment response.MethodsThis was a prospective study and informed consent was obtained from all patients. Thirty-three patients with uterine cervical cancer who received CCR underwent conventional MRI and DWI examinations prior to therapy (base-line) and at 3 days (postT1), 7 days (postT2), 14 days (postT3), 1 month (postT4) and 2 months (postT5) after the therapy initiated. Tumor response was determined by comparing the base-line and postT5 MRI by using RECIST criterion.ResultsPercentage ADC change (γADC) of complete response (CR) group at each follow up time was greater than that of partial response (PR) group, and the differences were significant at postT3 (p = 0.007), postT4 (p = 0.001), and postT5 (p = 0.019). There was positive correlation between γADC at each follow-up time and percentage size reduction at postT5. The day of 14 after the therapy initiated can be considered as the optimal time for monitoring early treatment response of uterine cervical cancer to CCR, and the representative and sensitive index was γADC. With the cut-off value of 35.4 %, the sensitivity and specificity for prediction of CR group were 100 % and 73.1 %, respectively.ConclusionsIt is feasible to use DWI to predict and monitor early treatment response in patients with uterine cervical cancer that undergoing CCR, and optimal time window for early detection of tumor response is the day of 14 after therapy initiated.

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“…In order to enhance survival rate of patients with cervical cancer, identification of new biomarker for early diagnosis, evaluation of prognosis and personalized therapy is critical. For example, the International Federation of Gynaecology and Obstetrics (FIGO) staging system does not contain information about lymph node metastasis (LNM) [ 2 ] because the current imaging technique (such as MRI, CT or PET-CT) has low sensitivity and high negative likelihood ratio for detecting LNM [ 3 – 6 ]. However, LNM is an important prognostic factor in cervical cancer patients [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

TRIM29 overexpression is associated with poor prognosis and promotes tumor progression by activating Wnt/β-catenin pathway in cervical cancer

Xu¹,

Zhang

et al. 2016

Oncotarget

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Dysregulation of TRIM29 has been reported to be involved in tumorigenesis, but the role of TRIM29 in cervical cancer is unclear. In this study, we first examined TRIM29 expression and found that TRIM29 mRNA and protein expression was upregulated in cervical cancer tissues when compared with the matched adjacent cervical tissues. We further detected TRIM29 protein with immunohistochemistry in 150 paraffin-embedded samples from early-stage cervical cancer patients. The results showed that high expression of TRIM29 was significantly associated with pelvic lymph node metastasis (p=0.002), advanced FIGO stage (p=0.026) and post-operative recurrence (p<0.001). Patients with high expression of TRIM29 had a shorter overall survival (HR 5.042, p<0.001) and disease-free survival (HR 4.260, p<0.001). TRIM29 was proven to be an independent prognostic factor for cervical cancer patients. When endogenous TRIM29 expression was knocked down by siRNAs, cell proliferation, colony formation, migration and invasion in cervical cancer cell lines HeLa and SiHa were obviously inhibited. Meanwhile, TRIM29 knockdown increased E-cadherin expression but decreased the expression of N-cadherin and β-Catenin, which indicated that TRIM29 could promote epithelial-mesenchymal transition (EMT). Mechanically, knockdown of TRIM29 enhanced GSK-3β protein expression and inhibited the expression of β-Catenin and C-myc proteins. GSK-3β is a key upstream suppressor of β-Catenin and c-myc expression is an indicator of Wnt/β-Catenin activity. Therefore, these results demonstrate that TRIM29 promotes tumor progression by activating Wnt/β-Catenin signaling. In conclusion, TRIM29 is overexpressed and associated with survival of early-stage cervical cancer, indicating that TRIM29 may be a potential prognostic biomarker and therapeutic target for cervical cancer.

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Diffusion-weighted MR imaging in gynecologic cancers

Cited by 34 publications

References 90 publications

Diffusion-weighted magnetic resonance imaging in the assessment of ovarian masses with suspicious features: Strengths and challenges

Diffusion-weighted magnetic resonance imaging in the assessment of ovarian masses with suspicious features: Strengths and challenges

Time-window of early detection of response to concurrent chemoradiation in cervical cancer by using diffusion-weighted MR imaging: a pilot study

TRIM29 overexpression is associated with poor prognosis and promotes tumor progression by activating Wnt/β-catenin pathway in cervical cancer

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