Diffusion-Weighted Magnetic Resonance Imaging (DWI)       Parameters in Benign and Malignant Ovarian Tumors       with Solid and Cystic Components

Zhuang, Yan; Wang, Tianping; Zhang, Guofu

doi:10.29271/jcpsp.2019.02.105

Cited by 9 publications

(8 citation statements)

References 21 publications

(21 reference statements)

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“…This finding is supported by the study of Zhuang and colleagues. 25 , who reported that the solid ADC in the benign group was significantly higher than the malignant group. The explanation for this may be that there was a higher rate of proliferation of malignant cells and a relatively small cell distance with a high molecular activity of water.…”

Section: Discussionmentioning

confidence: 98%

Correlation between ultrasound and Magnetic Resonance Imaging in diagnosis of Ovarian Tumors

Mansour

Tawfik

El-Barody³

et al. 2021

Al-Azhar International Medical Journal

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Background and objective: To discuss the value of ultrasound (US) and magnetic resonance imaging (MRI) in the evaluation of female patients with ovarian tumors. Methods: This study was performed on 250 patients at University hospital and the National Cancer Institute who were referred to radiodiagnosis department from the Obstetric and Gynecology department during the period from March 2017 to March 2018. All patients were subjected to pathology assessment, transvaginal ultrasonography (TVUS) and MRI with diffusion-weighted imaging (MRI-DWI). Results: The study group of 250 patients had a mean age of 38.85 ± 17.1 years. Lesions were classified according to histo-pathological analysis into benign (120 lesions, 48%) and malignant (130 lesions, 52%). Using US with Doppler, 105 cases were judged benign, and 145 cases were judged malignant. The sensitivity of the US with doppler examination the sensitivity was 81.51%, with 93.9% specificity, The positive predictive value (PPV) was 91%, and the NPV was 86%. MRI analysis indicated that the mean dimension of benign tumors was 7.6 ± 1.3 cm, while the mean dimension of malignant tumors was 12.3 ± 2.4 cm (p<0.001). The sensitivity of MRI was 96.43%, specificity was 95.83%, PPV. The apparent diffusion coefficient (ADC) values were 1.85 ± 0.58 for benign tumors and 0.84 ± 0.16 for malignant tumors. MRI-DWI showed 100% sensitivity, 93% specificity, 95.5% PPV, and 98% NPV. Conclusion: MRI-DWI are promising techniques for the evaluation and characterization of ovarian cancer.

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Section: Discussionmentioning

confidence: 98%

Correlation between ultrasound and Magnetic Resonance Imaging in diagnosis of Ovarian Tumors

Mansour

Tawfik

El-Barody³

et al. 2021

Al-Azhar International Medical Journal

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“…The present study results resembled with Elsammak et al, findings, who divided 42 lesions into 24 cases of benign lesions and 18 cases of malignant lesion group [12] and found that endometrial hyperplasia was the most common benign lesions whereas endometrial carcinoma was malignant lesions. Y. Zhuang et al found that in malignant lesions, endometrial carcinoma was the most prevalent endometrial lesions [13]. Another study conducted by Wang et al reported that 40 malignant lesions out of total 42 lesions were endometrial carcinoma and 7 out of 14 benign lesions were endometrial polyps.…”

Section: Discussionmentioning

confidence: 98%

Diagnostic Accuracy of Diffusion Weighted Magnetic Resonance in Differentiating Between Malignant and Benign Endometrial Soft-Tissue Lesions

Mughal¹,

Yaqoob²,

Abbasi³

et al. 2022

PJMHS

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Background and Aim: Pathological variation and image overlapping due to several endometrial conditions could be challenging for radiologists. Diffused weighted magnetic resonance imaging (DWI) is a reliable and promising imaging technique for the diagnosis and characteristics of endometrial lesions. The present study aimed to assess the diagnostic accuracy of diffused weighted magnetic imaging resonance in differentiating between malignant and benign endometrial soft-tissue lesions. Methodology: This descriptive cross-sectional study was carried out on 50 suspected endometrial lesions in the department of radiology, Benazir Bhutto hospital, Rawalpindi from January 2021 to December 2021. Non-probability consecutive sampling technique was used for all the participants meeting the inclusion criteria. Patients were categorized into two groups; Group I and Group II comprised 25 suspected benign and malignant endometrial lesions respectively. All the study patients were subjected to ultrasound and MRI examination of the pelvis. DWI imaging was done and the ADC value was calculated at a high b value. Histopathological data was collected. Data were analyzed using SPSS version 23. Results: Of the total 50 endometrial lesions, histopathological results were divided into the malignant group (25 lesions, 50%) and benign group (25 lesions, 50%). Out of 50, 38 lesions (21/25 benign and 17/25 malignant lesions) were correctly diagnosed by the conventional magnetic resonance imaging technique. The sensitivity, specificity, predictive positive value (PPV), and negative-positive value (NPV) of conventional MRI were 76.82%, 79.41%, 74.12%, AND 81.5% respectively. However, combining the apparent diffusion coefficient (ADC) value at b=1000 with DWI, about 48 lesions (24/25 benign and 24/25 malignant lesions) were correctly diagnosed. The sensitivity, specificity, predictive positive value (PPV), and negative-positive value (NPV) of conventional MRI were 94.82%, 93.23%, 91.6%, and 97% respectively. Conclusion: Diffusion-weighted MRI can help in distinguishing uterine endometrial lesions as benign and malignant. The diagnostic accuracy of Combined DWI with ADC mapping is higher than conventional MRI when differentiating benign lesions from malignant lesions. Additionally, sensitivity, specificity, and accuracy of combined DWI with ADC mapping increased in pelvic MRI examination for differentiating endometrial focal lesions. Keywords: Pelvic ultrasound; MRI Pelvis; Benign and Malignant endometrial lesions, Validity.

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“…It is also important to compare [ 68 Ga]Ga-PSMA-11 PET/CT with MRI including diffusionweighted imaging (DWI) and dynamic contrast-enhanced imaging (DCE), which now seems to very promising in differentiation of benign and malignant ovarian tumours [10,30].…”

Section: Discussionmentioning

confidence: 99%

[68Ga]Ga-Prostate-specific membrane antigen PET/CT in ovarian tumours: potential to differentiate benign and malignant tumours before surgery. A preliminary report

Kunikowska

Bizoń

Pełka

et al. 2022

Preprint

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Purpose Ovarian cancer is usually diagnosed in an advanced stage of disease due to the absence of specific symptoms and a lack of sensitive diagnostic methods. Prostate‑specific membrane antigen (PSMA) is expressed on prostate cancer cells, but can be found in other tumours such as ovarian cancer. The aim of this pilot study was to evaluate the feasibility of using [ 68 Ga]Ga-PSMA-11 PET/CT in detection of ovarian neoplasm before surgical treatment. Material and methods: Eight women with mean age of 56.0±16.2 years were included in the study. All patients underwent transvaginal ultrasound followed by CT scan of the chest and abdomen as qualification for surgery. Within a 1-week interval, PET/CT was performed on a Siemens Biograph scanner, 60 min after injection of 2 MBq/kg [ 68 Ga]Ga-PSMA-11. Results: In three cases (37.5%) the [ 68 Ga]Ga-PSMA-11 PET/CT was positive, whereas histological examination confirmed two serous ovarian cancer cases and one ovarian borderline tumour. The SUVmax in the serous ovarian cancer was 8.7 and 4.1, and in the borderline ovarian tumour it was 13.8. No correlation was found between antigen CA 125 level and [ 68 Ga]Ga-PSMA expression. Range of tumour SUVmax was not correlated with stage of disease. The remaining 62.5% (5/8) were negative in [ 68 Ga]Ga-PSMA-11 PET/CT and histopathology confirmed benign pelvic tumour. Conclusion The initial experience supports the potential to use [ 68 Ga]Ga-PSMA-11 in ovarian cancer to differentiate malignant and benign tumours before surgery. This study was approved by the Ethical Committee of the Medical University of Warsaw (KB/2/A/2018).

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Diffusion-Weighted Magnetic Resonance Imaging (DWI) Parameters in Benign and Malignant Ovarian Tumors with Solid and Cystic Components

Abstract: from January to December 2017. Forty-four patients with malignant ovarian tumours confirmed by clinicopathology were selected as a malignant group. At the same time, 44 cases of benign ovarian tumours confirmed by clinic pathology were selected as a benign

Cited by 9 publications

References 21 publications

Correlation between ultrasound and Magnetic Resonance Imaging in diagnosis of Ovarian Tumors

Correlation between ultrasound and Magnetic Resonance Imaging in diagnosis of Ovarian Tumors

Diagnostic Accuracy of Diffusion Weighted Magnetic Resonance in Differentiating Between Malignant and Benign Endometrial Soft-Tissue Lesions

[68Ga]Ga-Prostate-specific membrane antigen PET/CT in ovarian tumours: potential to differentiate benign and malignant tumours before surgery. A preliminary report

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