Diffusion-weighted magnetic resonance imaging: a potential non-invasive marker of tumour aggressiveness in localized prostate cancer

deSouza, Nandita M.; Riches, Sophie F.; As, Nicholas van; Morgan, Veronica A.; Ashley, Sue; Fisher, Cyril; Payne, Geoffrey S.; Parker, Christopher

doi:10.1016/j.crad.2008.02.001

Cited by 225 publications

(156 citation statements)

References 39 publications

Supporting

Mentioning

144

Contrasting

Unclassified

Order By: Relevance

“…Another limitation is the absence of Gleason score evaluation with MRI, which is a prognostic factor as important as tumor intraprostatic spread. In this study, we did not correlate, as suggested by others, 24 the absolute ADC value with the presence of high Gleason score tumor foci. This would require a different DWI protocol with several b-values and was beyond the scope of this project.…”

Section: Discussioncontrasting

confidence: 70%

Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer

Delongchamps

Beuvon

Eiss³

et al. 2011

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

To study the staging accuracy of multiparametric magnetic resonance imaging (MRI) in patients showing unilateral low-risk cancer on prostate biopsy. A total of 58 consecutive patients with lowrisk cancer (D'Amico classification) and unilateral cancer involvement on prostate biopsies were included prospectively. All patients underwent multiparametric endorectal MRI before radical prostatectomy, including T2-weighted (T2W), diffusion-weighted (DW) and dynamic contrast enhanced (DCE) sequences. Each gland was divided in eight octants. Tumor foci 40.2 cm 3 identified on pathological analysis were matched with MRI findings. Pathological examination showed tumor foci 40.2 cm 3 in 50/58 glands (86%), and bilateral tumor (pathological stageXpT2c) in 20/58 (34%). For tumor detection in the peripheral zone (PZ), T2W þ DWI þ DCE performed significantly better than T2W þ DWI and T2W alone (Po0.001). In the transition zone (TZ), only T2W þ DWI performed better than T2W alone (P ¼ 0.02). With optimal MR combinations, tumor size was correctly estimated in 77% of tumor foci involving more than one octant. Bilateral tumors were detected in 80% (16/20) of cases. In patients with unilateral low-risk prostate cancer on biopsy, multiparametric MRI can help to predict bilateral involvement. Multiparametric MRI may therefore have a prognostic value and help to determine optimal treatment in such patients.

show abstract

Section: Discussioncontrasting

confidence: 70%

Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer

Delongchamps

Beuvon

Eiss³

et al. 2011

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

show abstract

“…Lower signal-tonoise ratios may confound interpretation of different ADC values, as it could be impossible to determine whether the decrease in ADC is due to reduced SNR or true restriction of diffusion. Furthermore, several authors have demonstrated good results using b-values smaller than 1,000 sec/mm 2 [29,39].…”

Section: B-valuementioning

confidence: 99%

“…Zelhof et al [37] and Gibbs et al [38] showed that ADC values correlate inversely with increasing cellularity within the prostate gland. DeSouza and colleagues [39] found that patients in higher risk groups with lower ADC values had a greater tumour burden.…”

Section: Pre-treatment Detection: Tumour Localisation and Prognosticamentioning

confidence: 99%

See 1 more Smart Citation

Diffusion weighted imaging in prostate cancer

2010

View full text Add to dashboard Cite

Diffusion-weighted imaging has generated substantial interest in the hope that it can be developed into a robust technique to improve the accuracy of MRI for the evaluation of prostate cancer. This technique has the advantages of short acquisition times, no need for intravenous administration of contrast medium, and the ability to study diffusion of water molecules that indirectly reflects tissue cellularity. In this article, we review the existing literature on the utility of DWI in tumour detection, localisation, treatment response, limitations of the technique, how it compares with other imaging techniques, technical considerations and future directions.

show abstract

“…Thus, a combination of therapy and diagnostics (''theragnostics'') may take morphological and functional properties of the tumor into account, also utilizing non-invasive imaging modalities like dynamic contrast-enhanced magnetic resonance imaging (MRI), diffusion-weighted MRI and MR spectroscopy in order to acquire valuable information about metabolic composition, vascularization, hypoxia and structure (Fig. 2), and translate these into a personalized targeted therapy (''theragates'') [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Radiotherapy and inhibition of the EGF family as treatment strategies for prostate cancer: combining theragnostics with theragates

2010

View full text Add to dashboard Cite

Diffusion-weighted magnetic resonance imaging: a potential non-invasive marker of tumour aggressiveness in localized prostate cancer

Cited by 225 publications

References 39 publications

Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer

Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer

Diffusion weighted imaging in prostate cancer

Radiotherapy and inhibition of the EGF family as treatment strategies for prostate cancer: combining theragnostics with theragates

Contact Info

Product

Resources

About